A5068012713- Inhalation and Respiratory Drug Delivery
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Tracheal and airway disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Airway Management and Intubation Techniques
- Psychosomatic Disorders and Their Treatments
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Lung Cancer Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Mental Health and Psychiatry
- Human Health and Disease
- Cancer Diagnosis and Treatment
- Psychiatric care and mental health services
- Psychotherapy Techniques and Applications
- Suicide and Self-Harm Studies
- Pleural and Pulmonary Diseases
- Foreign Body Medical Cases
- Occupational exposure and asthma
- Respiratory and Cough-Related Research
- Adolescent and Pediatric Healthcare
- Lung Cancer Treatments and Mutations
- Childhood Cancer Survivors' Quality of Life
Postgraduate School of Molecular Medicine
2009-2023
Grochowski Hospital
2023
Centrum Medyczne Kształcenia Podyplomowego
2009-2022
Instytut Gruźlicy i Chorób Płuc
1991-2013
Institute for Postgraduate Medical Education
2011
Abstract In order to improve targeted therapeutic approaches for asthma patients, insights into the molecular mechanisms that differentially contribute disease phenotypes, such as obese asthmatics or severe asthmatics, are required. Here we report immunological and microbiome alterations in (n = 50, mean age 45), non-obese 53, 40), non-asthmatics 51, 44) their healthy counterparts 48, 39). Obesity is associated with elevated proinflammatory signatures, which enhanced presence of asthma....
Chronic active Epstein-Barr virus (EBV) disease (CAEBV) is defined as a severe, progressive lymphoproliferative disorder associated with EBV infection persisting longer than 6 months and developing in patients without recognised immunodeficiency. Rarely, interstitial pneumonitis (IP) occurs serious complication CAEBV patients. The standard therapeutic regimen for IP has not yet been defined. Although interferon alpha (IFN-alpha) known to suppress viral DNA replication by affecting its basal...
We have studied three different lavage procedures (100, 200 and 300 ml) in patients with pulmonary sarcoidosis (stage I). The effect of bronchoalveolar (BAL) on cell yield, fluid recovery, dwelling time, lavage-induced arterial oxygen desaturation occurrence side effects was analyzed. did not differ significantly prelavage lung function blood gas parameters. lowest BAL return seen the 300-ml procedure (49.5%), while medium yielded over 70%. yield 100 group (10.4 × 106); highest (19.4 106),...
Postoperative pain can be prevented. Gabapentin may effective in this role. Our primary objective was to test the hypothesis that a prophylactic administration of gabapentin obese patients before surgery has an opioid-sparing effect and reduces postoperative oxycodone consumption more efficiently than placebo.The study enrolled 113 undergoing laparoscopic sleeve-gastrectomy under general anesthesia. The were randomly allocated control or group received single oral dose 1200 mg matching...
The effectiveness of single-inhaler budesonide/formoterol fumarate combination therapy for asthma has been previously shown the original product. aim this nonrandomized, open-label, postauthorization efficacy study (PAES) real-life clinical assessment was to evaluate a second product (Bufomix Easyhaler®) in daily practice therapy. This multicenter PAES conducted by 220 unselected allergologists and pulmonologists who enrolled 2200 adult outpatients (age 49.8 ± 17.9 years) with treated...
The efficiency of lung drug delivery nebulized drugs is governed by aerosol quality, which depends both on the aerosolization process itself but also properties precursors. This paper determines physicochemical four analogous micro-suspensions a micronized steroid (budesonide, BUD) and seeks relationships between these quality emitted from vibrating mesh nebulizer (VMN). Despite same BUD content in all tested pharmaceutical products, their characteristics (liquid surface tension, viscosity,...
The most recently approved DPI's - Ellipta™ and NEXThaler® are the modern inhalers on market. Both flow independent in physiological range of flows seen patients with asthma and/or COPD. require three actions (open-load -inhaler) for a successful inhalation. inhaler is first DPI, which enables simultaneous delivery two compounds without need co-formulation. only DPI market delivering extra fine aerosol (MMAD < 2 μm) combined inhalation product inhaled corticosteroid long-action b2-agonist....
There is strong evidence of the role house dust mite (HDM) and human rhinovirus (HRV-16) in exacerbations asthma. Airway epithelium provides protection against inhaled factors through various pattern recognition receptors (PRRs). Some PRRs were shown to assemble into inflammasomes, leading secretion mature IL-1β IL-18. are limited data on activation inflammasome differentiated bronchial asthma its exacerbations. First, we performed next generation sequencing epithelial cells from asthmatic...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Emeryk A, Janeczek K, Markut-Miotła E, Pirożyński M, Florkiewicz E. Bronchodilator response after two methods of salbutamol nebulization in asthmatic children. Postępy Dermatologii i Alergologii/Advances Dermatology and Allergology. 2022. doi:10.5114/ada.2022.117038. APA Emeryk, A., Janeczek, K., Markut-Miotła, E., Pirożyński, M., & Florkiewicz, (2022). https://doi.org/10.5114/ada.2022.117038 Chicago Andrzej,...