A5075381883- Microbial infections and disease research
- Reproductive tract infections research
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Blood groups and transfusion
- Streptococcal Infections and Treatments
- Bacteriophages and microbial interactions
- Antibiotics Pharmacokinetics and Efficacy
- Syphilis Diagnosis and Treatment
- Genital Health and Disease
- Viral Infections and Vectors
- Antibiotic Resistance in Bacteria
- Gold and Silver Nanoparticles Synthesis and Applications
- Otolaryngology and Infectious Diseases
- Heat shock proteins research
- Neonatal Health and Biochemistry
- Neonatal Respiratory Health Research
- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Enzyme Production and Characterization
- Aquaculture disease management and microbiota
- Pneumocystis jirovecii pneumonia detection and treatment
- Mosquito-borne diseases and control
- Respiratory and Cough-Related Research
- Clostridium difficile and Clostridium perfringens research
First People's Hospital of Yunnan Province
2025
Kunming University of Science and Technology
2025
University of Alabama at Birmingham
2015-2024
Washington University in St. Louis
2024
Shandong University of Traditional Chinese Medicine
2024
Sichuan University
2011-2024
Broad Institute
2020-2023
Ministry of Education of the People's Republic of China
2012-2023
Sichuan Center for Disease Control and Prevention
2023
Sichuan Agricultural University
2023
In less than a decade, C. auris has emerged in health care settings worldwide; this species is capable of colonizing skin and causing outbreaks invasive candidiasis. contrast to other Candida species, unique its ability spread via nosocomial transmission high rates drug resistance. As part the public response, whole-genome sequencing played major role characterizing dynamics detecting new introductions. Through global collaboration, we assessed genome evolution isolates from 19 countries....
The aim of this study is to examine the functional role and resistance mechanisms Escherichia coli (E. coli) peptidoglycan transpeptidase gene, mrdA, in melittin. E. strains with either knockout or overexpression mrdA gene melittin was initially assessed. differences absorption between these two were evaluated following depletion heterologous expression gene. Subsequently, extracted from determine its capacity adsorb Finally, morphological changes different induced by exposure examined under...
Disseminated infection with Ureaplasma species causes fatal hyperammonemia syndrome in lung transplant recipients, likely by disrupting ammonia metabolism.
Pharyngitis guidelines focus solely on group A β-hemolytic streptococcal infection. European data suggest that in patients aged 15 to 30 years, Fusobacterium necrophorum causes at least 10% of cases pharyngitis; however, few U.S. exist.To estimate the prevalence F. necrophorum; Mycoplasma pneumoniae; and C/G pharyngitis determine whether clinically resembles pharyngitis.Cross-sectional.University student health clinic.312 students years presenting a clinic with an acute sore throat 180...
Macrolide-resistant Mycoplasma pneumoniae (MRMP) is highly prevalent in Asia and now being reported from Europe. Few data on MRMP are available the United States. Using genotypic phenotypic methods, we detected high-level 13.2% of 91 M. pneumoniae--positive specimens 6 US locations.
There are sparse data to indicate the extent that macrolide-resistant Mycoplasma pneumoniae (MRMp) occurs in United States or its clinical significance. Between 2015 and 2018, hospitals 8 states collected stored respiratory specimens tested positive for M. sent them University of Alabama at Birmingham, where real-time PCR was performed detection 23S rRNA mutations known confer macrolide resistance. MRMp detected 27 360 (7.5%). prevalence significantly higher South East (18.3%) than West...
Background: Epidemiologic data from Asia have documented the rapid and extensive emergence of macrolide resistance in Mycoplasma pneumoniae. This drug has also been Europe recently United States, but there is very little information currently available on its prevalence. A technique to identify macrolide-resistant M. pneumoniae needed guide management patients with community-acquired respiratory infections. Methods: Culture Minimum Inhibitory Concentration testing identified infection 2...
Abstract Background Ureaplasma urealyticum (UUR) and parvum (UPA) are sexually transmitted bacteria among humans implicated in a variety of disease states including but not limited to: nongonococcal urethritis, infertility, adverse pregnancy outcomes, chorioamnionitis, bronchopulmonary dysplasia neonates. There 10 distinct serotypes UUR 4 UPA. Efforts to determine whether difference pathogenic potential exists at the ureaplasma serovar level have been hampered by limitations antibody-based...
ABSTRACT We designed primers and probes for the detection discrimination of Ureaplasma parvum U. urealyticum their 14 serovars by real-time PCR. The analytical sensitivity specificity multiplex species-specific PCR were determined testing corresponding American Type Culture Collection (ATCC) type strains, 47 other microbial species, human genomic DNA. limits 2.8 × 10 −2 CFU/μl mixture detecting 4.1 . Clinical proven comparison with culture traditional For any clinical 96.9% 79.0%,...
Mycoplasma pneumoniae is a common pathogen that causes upper and lower respiratory tract infections in people of all ages, responsible for up to 40 % community-acquired pneumonias. It also wide array extrapulmonary autoimmune phenomena. Phylogenetic studies the organism have been generally restricted specific genes or regions genome, because whole genome sequencing has completed only 4 strains. To better understand physiology pathogenicity this important human pathogen, we performed...
We tested for Mycoplasma genitalium in 157 HIV-infected men. Urogenital and rectal prevalence were 10.8% 6.4%. Macrolide resistance mutations detected 70.6% 80% of urogenital samples, fluoroquinolone 26.7% 40%, respectively.
Abstract Background Human natural killer (NK) cells are the key contributors of innate immune response and effector functions these enhanced by cytokines such as interleukine 2 (IL2). We utilized genome-wide transcriptional profiling to identify gene expression signatures pathways in resting IL2 activated NK cell isolated from peripheral blood healthy donors. Results Gene showed high a number cytotoxic factors, cytokines, chemokines inhibitory activating surface receptors. Resting expressed...
ABSTRACT Ureaplasma parvum and urealyticum are sexually transmitted, opportunistic pathogens of the human urogenital tract. There 14 known serovars distributed between two species. For decades, it has been postulated based upon limited data that virulence is related to serotype specificity. The results were often inconclusive due small sample size extensive cross-reactivity certain serovars. We developed real-time quantitative PCRs allow reliable differentiation species type strains each To...
Mycoplasma pneumoniae is a major cause of community-acquired pneumonia. There are limited data in the United States on molecular epidemiological characteristics M. . We collected 446 -positive specimens from 9 states between August 2012 and October 2018. Culture, antimicrobial susceptibility testing, P1 subtyping, multilocus VNTR (variable-number tandem repeats) analysis (MLVA) were performed to characterize isolates.
Ureaplasma respiratory tract colonization is associated with bronchopulmonary dysplasia (BPD) in preterm infants. Whether the 4 parvum and 10 urealyticum serovars differ virulence unknown. This study was conducted to determine distribution of secretions a prospective cohort infants assess whether any are BPD.Serial endotracheal and/or nasopharyngeal aspirates were obtained for culture PCR from 136 gestational age <33 weeks. All positive samples speciated determined by real-time PCR.A total...