A5013821152- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Cervical Cancer and HPV Research
- Genital Health and Disease
- Pneumocystis jirovecii pneumonia detection and treatment
- Endometrial and Cervical Cancer Treatments
- Clostridium difficile and Clostridium perfringens research
- Neutropenia and Cancer Infections
- Antimicrobial Resistance in Staphylococcus
- Reproductive tract infections research
- Respiratory and Cough-Related Research
- Parasitic Diseases Research and Treatment
- Microscopic Colitis
- Antibiotic Use and Resistance
- Nosocomial Infections in ICU
- Plant Pathogens and Fungal Diseases
- Nail Diseases and Treatments
- SARS-CoV-2 and COVID-19 Research
- Antibiotics Pharmacokinetics and Efficacy
- Gastrointestinal motility and disorders
- Cystic Fibrosis Research Advances
- Poxvirus research and outbreaks
- Viral-associated cancers and disorders
- Bacillus and Francisella bacterial research
- Studies on Chitinases and Chitosanases
Centers for Disease Control and Prevention
2013-2024
National Center for Immunization and Respiratory Diseases
2018-2024
Office of Science
2019
Center for Surveillance, Epidemiology, and Laboratory Services
2019
Waterborne Environmental (United States)
2012-2015
National Center for Emerging and Zoonotic Infectious Diseases
2013-2015
Minnesota Department of Health
2015
Women’s Health Care
2000
On December 31, 2019, Chinese health officials reported a cluster of cases acute respiratory illness in persons associated with the Hunan seafood and animal market city Wuhan, Hubei Province, central China. January 7, 2020, confirmed that novel coronavirus (2019-nCoV) was this initial (1). As February 4, total 20,471 cases, including 2,788 (13.6%) severe illness,* 425 deaths (2.1%) had been by National Health Commission China (2). Cases have also 26 locations outside mainland China,...
Candidemia is common and associated with high morbidity mortality; changes in population-based incidence rates have not been reported.We conducted active, surveillance metropolitan Atlanta, Georgia, Baltimore City/County, Maryland (combined population 5.2 million), during 2008-2011. We calculated candidemia antifungal drug resistance compared prior (Atlanta, 1992-1993; Baltimore, 1998-2000).We identified 2675 cases of 2329 isolates 3 years surveillance. Mean annual crude per 100 000...
Recent reports have demonstrated a decline in bacterial bloodstream infections (BSIs) following adherence to central line insertion practices; however, declines been less evident for BSIs due Candida species.We conducted active, population-based laboratory surveillance candidemia metropolitan Atlanta, GA and Baltimore, MD over 5-year period. We calculated annual incidence antifungal drug resistance rates.We identified 3,848 cases from 2008-2013. Compared with 2008, per 100,000 person-years...
Between 2008 and 2011, population-based candidemia surveillance was conducted in Atlanta, GA, Baltimore, MD. Surveillance had been previously performed Atlanta 1992 to 1993 Baltimore 1998 2000, making this the first over multiple time points United States. From 2,675 identified cases of current surveillance, 2,329 Candida isolates were collected. albicans no longer comprised majority but remained most frequently isolated species (38%), followed by glabrata (29%), parapsilosis (17%),...
Fungal infections are rare complications of injections for treatment chronic pain. In September 2012, we initiated an investigation into fungal associated with preservative-free methylprednisolone acetate that was purchased from a single compounding pharmacy.Three lots were recalled by the pharmacy; examination unopened vials later revealed fungus. Notification all persons potentially exposed to implicated conducted federal, state, and local public health officials staff at clinical...
ABSTRACT Candida glabrata is the second leading cause of candidemia in U.S. hospitals. Current guidelines suggest that an echinocandin be used as primary therapy for treatment C. disease due to high rate resistance fluconazole. Recent case reports indicate echinocandins may increasing. We performed susceptibility testing on 1,380 isolates collected between 2008 and 2013 from four cities, Atlanta, Baltimore, Knoxville, Portland. Our analysis showed 3.1%, 3.3%, 3.6% were resistant...
Abstract Background. Echinocandins are first-line treatment for Candida glabrata candidemia. Echinocandin resistance is concerning due to limited remaining options. We used data from a multisite, population-based surveillance program describe the epidemiology and risk factors echinocandin nonsusceptible (NS) C Methods. The Centers Disease Control Prevention's Emerging Infections Program conducts laboratory candidemia in 4 metropolitan areas (7.9 million persons; 80 hospitals). identified...
ABSTRACT Candida parapsilosis is the second or third most common cause of candidemia in many countries. The Infectious Diseases Society America recommends fluconazole as primary therapy for C. candidemia. Although rate resistance among isolates low U.S. institutions, can be high 7.5%. This study was designed to assess mechanisms 706 incident bloodstream from hospitals. We sequenced ERG11 and MRR1 genes 122 with resistant (30 isolates; 4.2%), susceptible dose-dependent (37 5.2%), (55...
Infection is a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Our object was to better define the epidemiology outcomes infections HCT.This prospective, multicenter cohort study HCT recipients conducted from 2006 2011. The included 4 US transplant centers 444 recipients. Data were prospectively collected for up 30 months using standardized data collection tool.The median age 53 years, follow 413 (range, 5-980) days. most common reason...
Invasive mold infections (IMIs) are a major source of morbidity and mortality among lung transplant recipients (LTRs), yet information regarding the epidemiology IMI in this population is limited. From 2001 to 2006, multicenter prospective surveillance for IMIs LTR was conducted by Transplant-Associated Infection Surveillance Network. The all LTRs cohort reported. Twelve percent (143/1173) under at 15 US centers developed infections. 12-month cumulative incidence 5.5%; 3-month all-cause...
Abstract Background: The impact of human papillomavirus (HPV) vaccination has been observed in the United States through declining cervical precancer incidence young women. To further evaluate vaccine impact, we described trends HPV types 16/18 precancers, 2008–2014. Methods: We analyzed data from a 5-site, population-based surveillance system. Archived specimens women age 18–39 years diagnosed with intraepithelial neoplasia grades 2–3 or adenocarcinoma situ (CIN2+) were tested for 37 types....
ABSTRACT Exserohilum rostratum was the major cause of an outbreak fungal infections linked to injections contaminated methylprednisolone acetate. Because almost 14,000 persons were exposed product that possibly with multiple pathogens, there unprecedented need for a rapid throughput diagnostic test could detect both E. and other unusual agents infection. Here we report development novel PCR allowed specific detection DNA in cerebrospinal fluid (CSF), body fluids tissues infected individuals....
Since September 18, 2012, public health officials have been investigating a large outbreak of fungal meningitis and other infections in patients who received epidural, paraspinal, or joint injections with contaminated lots methylprednisolone acetate. Little is known about caused by Exserohilum rostratum, the predominant outbreak-associated pathogen. We describe early clinical course infections.We reviewed medical records for cases reported to Centers Disease Control Prevention before...
Human papillomavirus (HPV) causes approximately 30,000 cancers in the United States annually (1). HPV vaccination was introduced 2006 to prevent HPV-associated and diseases Cervical cancer is most common women Whereas typically take decades develop, screen-detected high-grade cervical lesions (cervical intraepithelial neoplasia grades 2 [CIN2], 3 [CIN3], adenocarcinoma situ, collectively CIN2+) develop within a few years after infection have been used monitor vaccine impact (1-3). CDC...
Histoplasmosis is one of the most common and deadly opportunistic infections among persons living with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome in Latin America, but due to limited diagnostic capacity this region, few data on burden clinical characteristics disease exist. Between 2005 2009, we enrolled patients ≥ 18 years age suspected histoplasmosis at a hospital-based HIV clinic Guatemala City. A case was defined as person presenting least three five or...
We describe trends in high-grade cervical lesions (CIN2+), identified through population-based surveillance 2008–2015. In addition to changed screening recommendations, observed CIN2+ declines among screened women aged 18–24 years indicate a population-level impact of human papillomavirus vaccination.
In September 2012, the Centers for Disease Control and Prevention (CDC) initiated an outbreak investigation of fungal infections linked to injection contaminated methylprednisolone acetate (MPA). Between 2 October 2012 14 February 2013, CDC laboratory received 799 isolates or human specimens, including cerebrospinal fluid (CSF), synovial fluid, abscess tissue, from 469 case patients in 19 states. A novel broad-range PCR assay DNA sequencing were used evaluate these specimens. Although...
ABSTRACT We validated an antigen capture enzyme-linked immunosorbent assay (ELISA) in Colombian persons with AIDS and proven histoplasmosis evaluated the correlation between antigenuria clinical improvement during follow-up. The sensitivity of Histoplasma capsulatum ELISA was 86%, overall specificity 94%. test successfully monitored response to therapy.
Primary prevention through the use of human papillomavirus (HPV) vaccination is expected to impact both cervical intraepithelial neoplasia (CIN) and adenocarcinoma in situ (AIS). While CIN well described, less known about epidemiology AIS, a rare precancer. We identified AIS grade 3 (CIN3) cases population‐based surveillance, analyzed data on HPV types incidence trends overall, among women screened for cancer. From 2008 2015, 470 6,587 CIN3 were identified. The median age with was older than...
Clostridium difficile infection (CDI) is a common complication of lung and allogeneic hematopoietic cell (HCT) transplant, but the epidemiology outcomes CDI after transplant are poorly described.We performed prospective, multicenter study within 365 days post-allogeneic HCT or transplantation. Data were collected via patient interviews medical chart review. Participants followed weekly in 12 weeks post-transplant while hospitalized contacted monthly up to 18 months post-transplantation.Six...
Histoplasmosis is common among persons living with human immunodeficiency virus/acquired immune deficiency syndrome (PLWHA) in Latin America, but its diagnosis difficult and often nonspecific. We conducted prospective screening for histoplasmosis PLWHA signs or symptoms suggesting progressive disseminated (PDH) hospitalized Hospital La María Medellín, Colombia. The study's aim was to obtain a clinical laboratory profile of PDH. During 3 years (May 2008 August 2011), we identified 89...
Abstract Declines in cervical intraepithelial neoplasia grades 2 to 3 and adenocarcinoma situ (CIN2+) observed among young women suggest impact from human papillomavirus (HPV) vaccination. To further evaluate vaccine including cross‐protection type replacement, we described high‐risk (HR)‐HPV type‐specific precancer incidence rates aged 20 39 years, 2008 2016. We analyzed cross‐sectional population‐based data on 18 344 cases of CIN2+ a 5‐site surveillance system. Diagnostic specimens were...
Although invasive cervical cancer (ICC) rates have declined since the advent of screening, annual age-adjusted ICC rate in United States remains 7.5 per 100,000 women. Failure recommended screening and management often precedes diagnoses. The study aimed to evaluate characteristics women with incident ICC, including potential barriers accessing preventive care.
Most studies of post-transplant CMV infection have focused on either solid organ or hematopoietic cell transplant (HCT) recipients. A large prospective cohort study involving both lung and HCT recipients provided an opportunity to compare the epidemiology outcomes infections in these 2 groups.Patients were followed up for 30 months a 6-center study. Data demographics, infections, tissue-invasive disease, recurrences, rejection, immunosuppression recorded.The overall incidence was 83/293...