A5044653047- Prenatal Substance Exposure Effects
- Pneumonia and Respiratory Infections
- Opioid Use Disorder Treatment
- Urbanization and City Planning
- Maternal Mental Health During Pregnancy and Postpartum
- Urban, Neighborhood, and Segregation Studies
- Gestational Diabetes Research and Management
- Obsessive-Compulsive Spectrum Disorders
- American Environmental and Regional History
- Respiratory viral infections research
- Race, History, and American Society
- Anesthesia and Pain Management
- Diabetes Treatment and Management
- Pain Management and Opioid Use
- Antifungal resistance and susceptibility
- Influenza Virus Research Studies
- Maternal and Perinatal Health Interventions
- Pregnancy and Medication Impact
- Substance Abuse Treatment and Outcomes
- Neurological disorders and treatments
- Pediatric Pain Management Techniques
- Body Image and Dysmorphia Studies
- Eating Disorders and Behaviors
- Diabetes Management and Research
- HIV, Drug Use, Sexual Risk
Vanderbilt University Medical Center
2015-2025
Baylor College of Medicine
2023-2025
Wisconsin Department of Health Services
2023
San Diego State University
1999-2020
Vanderbilt Health
2016-2019
Vanderbilt University
2016-2019
Nashville Oncology Associates
2019
Tennessee Department of Health
2012-2015
Saint Louis University
2013
Montclair State University
2011
Fungal infections are rare complications of injections for treatment chronic pain. In September 2012, we initiated an investigation into fungal associated with preservative-free methylprednisolone acetate that was purchased from a single compounding pharmacy.Three lots were recalled by the pharmacy; examination unopened vials later revealed fungus. Notification all persons potentially exposed to implicated conducted federal, state, and local public health officials staff at clinical...
We investigated an outbreak of fungal infections the central nervous system that occurred among patients who received epidural or paraspinal glucocorticoid injections preservative-free methylprednisolone acetate prepared by a single compounding pharmacy.Case were defined as with meningitis, posterior circulation stroke, spinal osteomyelitis, abscess developed after injections. Clinical and procedure data abstracted. A cohort analysis was performed.The median age 66 case 69 years (range, 23...
Background: Although certain opioid analgesics have immunosuppressive properties and increase the risk for infections in animals, clinical effects of prescription use on infection among humans are unknown. Objective: To test hypothesis that is an independent factor invasive pneumococcal disease (IPD). Design: Nested case–control study. Setting: Tennessee Medicaid database linked to Medicare Active Bacterial Core surveillance system databases (1995 2014). Patients: 1233 case patients with IPD...
Animal studies and in vitro human suggest that certain opioid analgesics impair crucial immune functions. This study was undertaken to determine whether use is associated with increased risk of serious infection patients rheumatoid arthritis (RA).We conducted a self-controlled case series analysis on retrospective cohort 13,796 RA enrolled Tennessee Medicaid 1995-2009. Within-person comparisons the hospitalization for during periods versus non-use were performed using conditional Poisson...
Objectives Hospitalisations for serious infections are common among middle age and older adults frequently used as study outcomes. Yet, few studies have evaluated the performance of diagnosis codes to identify in this population. We sought determine positive predictive value (PPV) identifying hospitalisations due adults. Setting participants identified possible infection >=50 years enrolled Tennessee Medicaid healthcare programme (2008–2012) using International Classifications Diseases,...
Although evidence from animal and human studies indicates opioid analgesics increase susceptibility to infections, it is unclear whether the risk varies by specific opioid. We compared of serious infection among patients initiating long-acting with without previously reported immunosuppressive properties.We conducted a retrospective cohort study Tennessee Medicaid enrollees age ≥18 years opioids (1995-2015). Hospitalizations for were identified using validated coding algorithms. used...
Importance Opioid exposure during pregnancy has been associated with preterm birth, but prior studies have not differentiated between spontaneous and indicated birth or fully investigated these associations as functions of opioid dose. Objective To determine whether prescription use is the association dose-dependent. Design, Setting, Participants This case-control study examined a retrospective cohort pregnant patients enrolled in Tennessee Medicaid. Enrollment files were linked to health...
BACKGROUND The American Academy of Pediatrics recommends up to 7 days observation for neonatal opioid withdrawal syndrome (NOWS) in infants with chronic exposure. However, many these will not develop NOWS, and seemingly less exposure opioids may severe NOWS that requires in-hospital pharmacotherapy. We adapted validated a prediction model help clinicians identify at birth who NOWS. METHODS This prognostic study included 33 991 births. Severe was defined as administration oral morphine....
Importance Opioid use disorder (OUD) in pregnancy has grown the US. Buprenorphine, a medication to treat OUD, may improve outcomes; however, most pregnant individuals do not receive it. Research evaluating buprenorphine pregnancy, its effects on maternal-infant dyad, and comparison no treatment is limited. Objective To determine if with for opioid associated improved maternal infant outcomes compared among mothers OUD. Design, Setting, Participants This retrospective cohort study included...
Abstract Purpose PCORnet, the National Patient‐Centered Clinical Research Network, represents an innovative system for conduct of observational and pragmatic studies. We describe identification validation a retrospective cohort patients with type 2 diabetes (T2DM) from four PCORnet sites. Methods adapted existing computable phenotypes (CP) T2DM evaluated their performance across sites (2012‐2016). Patients entered on earliest date they met one three CP categories: (CP1) coded diagnosis...
Abstract Background and Objectives Addiction consultation services provide access to specialty addiction care during general hospital admission. This study assessed opioid use disorder (OUD) outcomes associated with consultation. Methods Retrospective cohort of individuals OUD admitted an academic medical center between 2018 2023. The exposure was Outcomes included initiating medication for (MOUD), length stay, before‐medically‐advised (BMA) discharge, 30‐ 90‐day postdischarge acute...
Acute myocardial infarction (AMI) events have been reported among patients with certain viral and bacterial infections. Whether invasive pneumococcal disease (IPD) increases the risk of AMI remains unclear. We examined whether laboratory-confirmed IPD was associated AMI.
As the popularity of text-based source code analysis grows, use stemmers to strip suffixes has increased. Stemmers have been used more accurately determine relevance between a keyword query and methods in for search, exploration, bug localization. In this paper, we investigate which traditional perform best on domain software, specifically, Java code. We compare using two case studies: comparative unified word classes terms accuracy completeness, as well an investigation into effectiveness...