A5081260790- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Plant Pathogens and Fungal Diseases
- Infectious Diseases and Mycology
- Nail Diseases and Treatments
- Cystic Fibrosis Research Advances
- Bacterial Identification and Susceptibility Testing
- Yeasts and Rust Fungi Studies
- Fungal Biology and Applications
- Sinusitis and nasal conditions
- Enzyme Production and Characterization
- Bacterial biofilms and quorum sensing
- Biofuel production and bioconversion
- Orthopedic Infections and Treatments
- Oral microbiology and periodontitis research
- Antibiotic Resistance in Bacteria
- Infections and bacterial resistance
- Essential Oils and Antimicrobial Activity
- Enterobacteriaceae and Cronobacter Research
- Mycobacterium research and diagnosis
- Microbial Metabolites in Food Biotechnology
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycorrhizal Fungi and Plant Interactions
- Plant Disease Resistance and Genetics
- Parasitic Diseases Research and Treatment
Hamad Medical Corporation
2016-2025
University of Babylon
1992-2025
Weill Cornell Medical College in Qatar
2015-2023
Hospital for Special Surgery
2015-2016
Qatar Airways (Qatar)
2015
Astellas Pharma (Japan)
2015
Novartis (Switzerland)
2015
Pfizer (United States)
2015
Enzon Pharmaceuticals (United States)
2015
Pfizer (United Kingdom)
2015
Abstract The fungal pathogen Candida glabrata has emerged as a major health threat since it readily acquires resistance to multiple drug classes, including triazoles and/or echinocandins. Thus far, cellular mechanisms promoting the emergence of classes have not been described in this organism. Here we demonstrate that mutator phenotype caused by mismatch repair defect is prevalent C. clinical isolates. Strains carrying alterations gene MSH2 exhibit higher propensity breakthrough antifungal...
Invasive fungal infections (IFIs) in Asia/Pacific are a particular threat to patients with malignancies, uncontrolled diabetes mellitus or undiagnosed/untreated human immunodeficiency virus infection and acquired syndrome (HIV/AIDS). Adequate early access diagnostic tools antifungals is essential for IFI clinical management patient survival.Details on institution profile, self-perception IFI, microscopy, culture, serology, antigen detection, molecular testing, therapeutic drug monitoring...
Cryptococcosis is a major fungal disease caused by members of the Cryptococcus gattii and neoformans species complexes. After more than 15 years molecular genetic phenotypic studies much debate, proposal for taxonomic revision was made.
ABSTRACT Matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) was used for an extensive identification study arthroconidial yeasts, using 85 reference strains from the CBS-KNAW yeast collection and 134 clinical isolates collected medical centers in Qatar, Greece, Romania. The test set included 72 ascomycetous yeasts ( Galactomyces , Geotrichum Saprochaete Magnusiomyces spp.) 147 basidiomycetous Trichosporon Guehomyces spp.). With minimal preparation...
Cryptococcosis is an important fungal disease in Asia with estimated 140,000 new infections annually the majority of which occurs patients suffering from HIV/AIDS. Cryptococcus neoformans variety grubii (serotype A) major causative agent this disease. In present study, multilocus sequence typing (MLST) using ISHAM MLST consensus scheme for C. neoformans/C. gattii species complex was used to analyse nucleotide polymorphisms among 476 isolates pathogen obtained 8 Asian countries. Population...
Objectives: Invasive mold infections associated with Aspergillus species are a significant cause of mortality in immunocompromised patients. The most frequently occurring aetiological pathogens members the section Fumigati followed by Terrei. frequency terreus and related (cryptic) clinical specimens, as well percentage azole-resistant strains remains to be studied. Methods: A global set (n = 498) A. phenotypically isolates was molecularly identified (beta-tubulin), tested for antifungal...
Eleven uncommon yeast species that are associated with high mortality rates irrespective of antifungal therapy were isolated from 17/187 (201 episodes) pediatric and elderly patients fungemia Qatar. The samples taken over a 6-year period (January 2004–December 2010). Isolated included Kluyveromyces marxianus, Lodderomyces elongisporus, Lindnera fabianii, Candida dubliniensis, Meyerozyma guilliermondii, intermedia, Pichia kudriavzevii, Yarrowia lipolytica, Clavispora lusitaniae, pararugosa,...
Candida glabrata is a commensal yeast of the gastrointestinal tract and skin humans. However, it causes opportunistic infections in immunocompromised patients, second most common pathogen causing bloodstream infections. Although there are many studies on epidemiology C. infections, fine- large-scale geographical nature remain incompletely understood. Here we investigated both population structure through genome sequencing 80 clinical isolates obtained from six tertiary hospitals Qatar by...
Trichosporon species have been reported as emerging pathogens and usually occur in severely immunocompromised patients. In the present work, 27 clinical isolates of were recovered from The patients not immunocompromised, except for one with acute myeloid leukemia. Sequence analysis revealed isolation dohaense Taj-Aldeen, Meis & Boekhout sp. nov., CBS 10761(T) holotype strain, belonging to Ovoides clade. D1-D2 large-subunit rRNA gene analysis, T. is a sister coremiiforme, internal transcribed...
Background Cryptococcus neoformans is a pathogenic yeast that causes cryptococcosis, life threatening disease. The prevalence of cryptococcosis in Asia has been rising after the onset AIDS epidemic and estimates indicate more than 120 cases per 1,000 HIV-infected individuals year. Almost all cryptococcal disease both immunocompromised immunocompetent patients are caused by C. var. grubii. Epidemiological studies on pan-Asia have not reported. present work genetic diversity fungus...
Abstract Background. Candida arthritis is a debilitating form of deeply invasive candidiasis. However, its epidemiology, clinical manifestations, management, and outcome are not well understood. Methods. Cases were reviewed from 1967 through 2014. Variables included spp in joint and/or adjacent bone, underlying conditions, inflammatory biomarkers, diagnostic imaging, outcome. Results. Among 112 evaluable cases, 62% males 36% pediatric. Median age was 40 years (range, <1–84 years)....
Summary Few estimates of fungal disease frequency have been attempted in the Middle East. We estimated burden infections Qatar. The aim study was to compute and determine serious infections, an attempt estimate frequency, which has not previously this country. Disease statistics were collected from Microbiology laboratory database 2011 WHO statistics. data are expressed per 100 000 populations. reported cases candidaemia rose 288 with rate 15.4/100 000. A real increase found over that...
Purpose: Bloodstream infections in pediatric hematology and oncology represent a major problem worldwide, but this has not been studied Qatar. In study, we investigated the burden of infection resistance pattern bacterial etiology, only tertiary center Methods: All cancer patients (n=185) were evaluated retrospectively during period 2004–2011; total 70 (38%) diagnosed with bloodstream infections. Bacterial etiology was determined, along their susceptibility patterns. Neutropenia, duration...