A5072013289- Functional Brain Connectivity Studies
- Respiratory viral infections research
- Influenza Virus Research Studies
- Advanced Neuroimaging Techniques and Applications
- COVID-19 Clinical Research Studies
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Tuberculosis
- Diagnosis and treatment of tuberculosis
- Genetic Associations and Epidemiology
- Coronary Artery Anomalies
- Congenital Diaphragmatic Hernia Studies
- Congenital Heart Disease Studies
- Metabolism and Genetic Disorders
- HIV/AIDS drug development and treatment
- Birth, Development, and Health
- Dementia and Cognitive Impairment Research
- HIV/AIDS Research and Interventions
- Folate and B Vitamins Research
- Health, Environment, Cognitive Aging
- Pharmaceutical and Antibiotic Environmental Impacts
- Machine Learning in Healthcare
- Neonatal Health and Biochemistry
- Neutropenia and Cancer Infections
- Enterobacteriaceae and Cronobacter Research
- COVID-19 epidemiological studies
University College London
2021-2022
Sidra Medical and Research Center
2020-2022
Weill Cornell Medical College in Qatar
2014-2020
Qatar Foundation
2020
Hamad Medical Corporation
2007-2015
Hamad General Hospital
2002-2015
Predicting cognitive decline using MRI measures of brain volume is challenging. Normative models capture the evolution biomarkers over time in a healthy group, quantifying an individuals deviation from that norm. Here, we improve precision normative for hippocampal volume, key biomarker, by integrating multi-threshold polygenic scores (PGS) genetic predisposition to its variability. We built Gaussian Process Regression (GPR) on genetic, imaging, and demographic data 23,997 UK Biobank (UKBB)...
Purpose: Bloodstream infections in pediatric hematology and oncology represent a major problem worldwide, but this has not been studied Qatar. In study, we investigated the burden of infection resistance pattern bacterial etiology, only tertiary center Methods: All cancer patients (n=185) were evaluated retrospectively during period 2004–2011; total 70 (38%) diagnosed with bloodstream infections. Bacterial etiology was determined, along their susceptibility patterns. Neutropenia, duration...
Introduction: Although extended-spectrum β-lactamase (ESBL)-producing Enterobacterales are a public health problem in the Arabian Peninsula, data on molecular characteristic of their antimicrobial resistance determinants children is limited. Aim: To determine characteristics ESBL-producing Escherichia coli and Klebsiella pneumoniae pediatric population Qatar. Methods: Whole-genome sequencing (WGS) was performed E. K. isolates recovered from screening clinical specimens patients at Sidra...
The novelty of the coronavirus disease 2019 (COVID-19) has led some researchers to use influenza models and changes in activity infer impact social distancing measures mitigate transmission severe acute respiratory syndrome 2 (SARS-CoV-2).1, However, it been argued that effectiveness school closure reduce is not transferrable COVID-19 pandemic given alleged lower attack rate children compared with adults greater basic reproductive number SARS-CoV-2 as opposed influenza.3 Sidra Medicine main...
Nomograms are important clinical tools applied widely in both developing and aging populations. They generally constructed as normative models identifying cases outliers to a distribution of healthy controls. Currently used do not account for genetic heterogeneity. Hippocampal volume (HV) is key endophenotype many brain disorders. Here, we examine the impact adjustment on HV nomograms translational ability detect dementia patients. Using imaging data from 35,686 subjects aged 44-82 UK...
HIV-1-infected children are often treated with therapy regimens including protease inhibitors (PIs). We monitored the virologic response in a small group of pediatric patients undergoing PI nelfinavir and determined whether new drug resistance mutations were present immediately after failure. Seventeen reverse transcriptase inhibitor (RTI)-experienced starting nelfinavir-containing studied. After failure, HIV-1 (PR) RT sequences examined for mutations. Viral load levels decreased to <400 HIV...
Respiratory syncytial virus (RSV) is the major cause of acute lower respiratory tract infections in early childhood. Annual epidemics occur which are well documented developed countries during winter months, placing considerable pressure on provision health care. Little known about epidemiology RSV Middle East and other desert climate regions world. The objective this study was to determine infection rate seasonality among children 2 years old or younger its correlation with meteorological...
Abstract Background Normative Models are widely used across clinical applications from infant growth charts to brain volume charts. For Alzheimer’s disease (AD), reduction in hippocampal (HV) is an early and often presymptomatic feature. Thus, precisely measuring deviation of HV healthy aging facilitates earlier diagnosis. Brain volumes have been reported with heritability 40‐90%, thus, implying that normative ranges heavily influenced by genetics. Here we investigate whether genetic...
To correlate standard tuberculin skin test (TST) results in children diagnosed with active tuberculosis (TB), data was collected retrospectively from the treatment unit, State of Qatar, during period 1992 to 1996. Sixtysix patients confirmed included 42 (64%) pulmonary TB, 24 (36%) extra-pulmonary 34 Qatar nationals (52%) and 36 females (55%). Mean TST 13.5 mm ± 9.8mm. negative 18 (27%), 5-10 three (5%), 10-15 eight (12%) 15mm or more 37 (56%) patients. Lower false (reaction less than 10mm)...
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Nomograms are important clinical tools applied widely in both developing and aging populations. They generally constructed as normative models identifying cases outliers to a distribution of healthy controls. Currently used do not account for genetic heterogeneity. Hippocampal Volume (HV) is key endophenotype many brain disorders. Here, we examine the impact adjustment on HV nomograms translational ability detect dementia patients. Using imaging data from 35,686 subjects aged 44 82 UK...