A5023925485- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Thermal Regulation in Medicine
- Immune Cell Function and Interaction
- Tryptophan and brain disorders
- Acoustic Wave Resonator Technologies
- Protein purification and stability
- GaN-based semiconductor devices and materials
- Polymer Surface Interaction Studies
- Diversity and Career in Medicine
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Electrospun Nanofibers in Biomedical Applications
- HIV Research and Treatment
- Medical Education and Admissions
- T-cell and B-cell Immunology
- Insect symbiosis and bacterial influences
- Advanced biosensing and bioanalysis techniques
- Immune responses and vaccinations
- Health and Medical Research Impacts
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- SARS-CoV-2 and COVID-19 Research
Stanford University
2024-2025
Icahn School of Medicine at Mount Sinai
2014-2019
Czech Academy of Sciences, Institute of Microbiology
2017
Pomona College
2007-2012
At this stage in the COVID-19 pandemic, most infections are "breakthrough" that occur individuals with prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure. To refine long-term vaccine strategies against emerging variants, we examined both innate and adaptive immunity breakthrough infections. We performed single-cell transcriptomic, proteomic, functional profiling of primary to compare immune responses from unvaccinated vaccinated during SARS-CoV-2 Delta wave....
ABSTRACT The type I interferon-inducible factor tetherin retains virus particles on the surfaces of cells infected with vpu -deficient human immunodeficiency 1 (HIV-1). While this mechanism inhibits cell-free viral spread, immunological implications tethered have not been investigated. We found that surface expression increased antibody opsonization HIV-infected cells. absence Vpu also stimulated NK cell-activating FcγRIIIa signaling and enhanced cell degranulation cell-mediated...
Sex differences have been observed in acute coronavirus disease 2019 (COVID-19) and Long Covid (LC) outcomes, with greater severity mortality during infection males proportions of females developing LC. We hypothesized that sex-specific immune dysregulation contributes to LC pathogenesis. To investigate the immunologic underpinnings development symptom persistence, we performed multiomic analyses on blood samples obtained severe respiratory syndrome 2 (SARS-CoV-2) 3 12 months after a cohort...
This work describes the immobilization of β-galactosidase onto polyelectrolyte multilayer assemblies polyanion poly[1-[4-(3-carboxy-4-hydroxyphenylazo)benzenesulfonamido]-1,2-ethanediyl, sodium salt] (PAZO) and polycation poly(ethylenimine) (PEI) constructed by electrostatic self-assembly (ESA). A single layer was deposited over a precursor film comprising up to five bilayers PEI/PAZO pair. The enzyme on both polycationic polyanionic surfaces. Quartz crystal microbalance with dissipation...
Dengue virus (DENV) is the most prevalent mosquito-borne causing human disease. Of 4 DENV serotypes, epidemiological data suggest that DENV-2 secondary infections are associated with more severe disease than DENV-4 infections. Mass cytometry by time-of-flight (CyTOF) was used to dissect immune changes induced and in DCs, initial targets of primary likely affect infection outcomes. Strikingly, replication peaked earlier promoted stronger innate responses, increased expression DC activation...
Abstract Sex differences have been observed in acute COVID-19 and Long COVID (LC) outcomes, with greater disease severity mortality during infection males a proportion of females developing LC. We hypothesized that sex-specific immune dysregulation contributes to the pathogenesis To investigate immunologic underpinnings LC development persistence, we used single-cell transcriptomics, proteomics, plasma proteomics on blood samples obtained SARS-CoV-2 at 3 12 months post-infection cohort 45...
Abstract Previous studies have found that commercial human pregnancy tests are often too insensitive to function their advertised >99% accuracy. Improper orientation of proteins used for recognition ligands in sensors can prevent the binding site from being available ligand, thereby decreasing sensor sensitivity. We developed a simple method immobilization anti‐human chorionic gonadotropin on surface maximizes its sensitivity by ensuring ligand sites exposed and densely packed. This also...
Context: Despite equal enrollment proportions in MD and PhD programs, there are fewer women than men MD-PhD programs academic medicine. Factors important degree program selection, including the perception of gender disparities, among undergraduate students were characterized. Methods: In 2017, pre-health at four public North Carolina universities invited to participate an online survey regarding career plans, decision factors, perceptions disparities MD, pathways. This study characterizes...