A metal-free convergent paired electrolysis strategy to synthesize benzylic amines through direct arylation of tertiary and benzonitrile derivatives at room temperature has been developed. This TEMPO-mediated electrocatalytic reaction makes full use both anodic oxidation cathodic reduction without metals or stoichiometric oxidants, thus showing great potential advantages for practical synthesis. method provides a straightforward powerful means activate C-H bonds realize cross-coupling with...

Abstract By merging electricity with sulfate, the Ritter-type amination of C(sp 3 )-H bonds is developed in an undivided cell under room temperature. This method features broad substrate generality (71 examples, up to 93% yields), high functional-group compatibility, facile scalability, excellent site-selectivity and mild conditions. Common alkanes electron-deficient alkylbenzenes are viable substrates. It also provides a straightforward protocol for incorporating C-deuterated acetylamino...

Metabolic regulators can improve the athletic ability of athletes by regulating body metabolism, but it is not conducive to fair competition, so listed as a prohibited substance. At same time, State General Administration Sport ordered major event organizers test food for food-borne stimulants. Surface-enhanced Raman scattering (SERS) spectroscopy has been widely used because its excellent sensitivity and strong spectral characteristics. Based on available information, SERS spectrum data...

A continuous flow protocol for the preparation of benzyne has been developed utilizing readily accessible 1-bromo-2-iodobenzene and iPrMgCl·LiCl. The halogen-magnesium exchange subsequent elimination reaction were conducted at temperatures of...

Transition metal catalyzed [2+2+2] cycloaddition reactions between three alkynes, a diyne and an alkyne, or triyne offer straightforward typical protocol toward all kinds of polysubstituted benzens. Herein, the synthesis aromatics through electrochemical nickel cyclotrimerization alkynes is developed. The regio‐divergent terminal was achieved by judicious choice ligands. And tributylphosphine, sterically hindered bipyridine β‐diketone ligands delivered 1,2,4‐ 1,3,5‐substituted with high...

Abstract We report the first electrochemical strategy to synthesize functionalized naphthalene derivatives through [4+2] annulation—rearrangement–aromatization from styrenes under mild conditions. The electrolysis does not require metals, oxidants and high valence substrates, indicating atom step‐economy ideals. dehydrodimer produced cycloaddition of 4‐methoxy α‐methyl styrene is isolated proved be key intermediate for following oxydehydrogenation form carbon cation, which undergoes...

We develop an electrochemical nickel-catalyzed aminomethylation of aryl bromides under mild conditions. The convergent paired electrolysis makes full use anode and cathode processes, free a terminal oxidant, sacrificial anode, metal reductant, prefunctionalized radical precursor. In addition, this method exhibits wide functional group tolerance (63 examples), including some sensitive substituents aromatic heterocycles. This redox neutral cross coupling provides more environmentally friendly...

An iridium catalytic system with a ferrocene-based phosphine ligand bearing modular and tunable unsymmetrical vicinal diamine scaffold was developed for the asymmetric hydrogenation of aryl ketones. This approach provided powerful tool enantioselective synthesis diverse chiral alcohols excellent reactivity enantioselectivity (up to 99% yield, up ee, 50,000 turnover number). The substituents chirality diamines in ligands played an important role satisfactory results.

Abstract A metal‐free convergent paired electrolysis strategy to synthesize benzylic amines through direct arylation of tertiary and benzonitrile derivatives at room temperature has been developed. This TEMPO‐mediated electrocatalytic reaction makes full use both anodic oxidation cathodic reduction without metals or stoichiometric oxidants, thus showing great potential advantages for practical synthesis. method provides a straightforward powerful means activate C−H bonds realize...

Chiral γ-amino alcohols are the prevalent structural motifs and building blocks in pharmaceuticals bioactive molecules. Enantioselective hydrogenation of β-amino ketones provides a straightforward powerful tool for synthesis chiral alcohols, but asymmetric transformation is synthetically challenging. Here, series tridentate ferrocene-based phosphine ligands bearing modular tunable unsymmetrical vicinal diamine scaffolds were designed, synthesized, evaluated iridium-catalyzed ketones. The...

Abstract Due to the high oxidation potentials of electron‐deficient aromatic hydrocarbons, it is difficult achieve direct oxidative C(sp 2 )−H bonds functionalizations such substrates. Herein, we develop a Ritter‐type amination aromatics by merging electricity and sulfate. This practical straightforward method provides series acetanilides from simple arenes, including mono‐, di‐ tri‐substituted arenes (22 examples, up 75 %) with moderate good yields under mild conditions. characterized cheap...

This work reports a one-pot asymmetric synthesis of spirocyclopropyl propionaldehydes/propanols via β,γ-bifunctionalization propanols through the synergistic effect secondary amine catalyst and an oxidant.

Novel and homogeneous zirconium phosphonate-supported Pd catalysts with modest BET surface areas (25.6 24.7 m2 g−1), high pore volumes (0.39 0.73 cc g−1) nano-sized pores (1–10 nm) were prepared by embedding Na2PdCl4 particles in an organosoluble, porous layered phosphonate a filiform architecture structure for the first time. In palladium-catalyzed Suzuki coupling reaction at room temperature, various substituted benzene bromides phenylboronic acids smoothly converted into corresponding...

A metal-free photoredox catalyzed decarboxylative radical coupling of free-carboxylic acids and glyoxylic oximes was developed to synthesize α,β-diamino acids.

A continuous flow process for the preparation of betahistine with a 90% isolated yield has been reported. 2-Vinylpyridine and saturated methylamine hydrochloride aqueous solution were used as starting materials to achieve excellent results in silicon carbide reactor, which can tolerate corrosion chloride ions at high temperature (170 °C) pressure (25 bar). In process, product be obtained 2.4 min conversion (>99%) selectivity (94%). The throughput reach 1.06 kg h–1, purity final was greater...

Herein, we report a computation study based on the density functional theory calculations to understand mechanism and ligand effect of base-stabilized dialumenes toward dihydrogen activation. Among all examined modes activation using dialumene, found that concerted 1,2-hydrogenation Al═Al double bond is kinetically more preferable. The adopts an electron-transfer model with certain asynchrony. That is, initial electron donation from H–H σ bonding orbital empty 3p Al1 center followed by...