A5070999062- MicroRNA in disease regulation
- Microbial Natural Products and Biosynthesis
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Microfluidic and Capillary Electrophoresis Applications
- Supercapacitor Materials and Fabrication
- Marine Sponges and Natural Products
- Advancements in Battery Materials
- Microfluidic and Bio-sensing Technologies
- Fungal Biology and Applications
- RNA Research and Splicing
- Glioma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Graphene and Nanomaterials Applications
- Chemokine receptors and signaling
- Cholesterol and Lipid Metabolism
- Neonatal and fetal brain pathology
- Medicinal Plants and Bioactive Compounds
- Berberine and alkaloids research
- Thermal Regulation in Medicine
- RNA regulation and disease
- Scientific and Engineering Research Topics
- Genomics, phytochemicals, and oxidative stress
Harbin Medical University
2010-2025
Guangxi University
2022-2023
Lanzhou University
2022
Chinese Academy of Sciences
2018-2021
South China Sea Institute Of Oceanology
2018-2021
Institute of Oceanology
2018-2021
Beijing Normal University
2021
University of Chinese Academy of Sciences
2018-2020
Second Affiliated Hospital of Harbin Medical University
2010-2019
Shanxi University
2018-2019
A new spirocyclic γ-lactam, named spirostaphylotrichin X (1), and three related known spirostaphylotrichins (2–4) were isolated from the marine-derived fungus Cochliobolus lunatus SCSIO41401. Their structures determined by spectroscopic analyses. Spirostaphylotrichin (1) displayed obvious inhibitory activities against multiple influenza virus strains, with IC50 values 1.2 to 5.5 μM. Investigation of mechanism showed that 1 inhibited viral polymerase activity interfered production progeny...
Three new eremophilane sesquiterpenes, dendryphiellins H–J (1–3), and three phthalide natural products (4–6) were isolated from the marine-derived fungus Cochliobolus lunatus SCSIO41401. Their structures including absolute configurations determined by spectroscopic calculated ECD analyses. Dendryphiellin I (2) showed cytotoxic antibacterial activities against five cancer cell lines (IC50 1.4 to 4.3 μM) bacterial species (MIC 1.5 13 μg/mL), respectively. J (3), a rare naturally occurring...
Glioma remains one of the most aggressive and lethal cancers in central nervous system. Temozolomide (TMZ) is commonly used chemotherapeutic agent gliomas. However, therapeutic benefits TMZ could be very limited all patients would finally suffer from tumor progression as tumors develop resistance to TMZ. In this study, we aim investigate underlying mechanism chemoresistance glioma cell line identify whether there still a close link between epithelial-mesenchymal transition (EMT) The...
Tetrandrine (TET), a bisbenzylisoquinoline alkaloid isolated from the root of Hang-Fang-Chi (Stephania tetrandra S. Moore), exhibits broad pharmacological effects, including antitumor activity in various malignant neoplasms. Recently, beneficial effects TET on cytotoxicity towards tumor cells, radiosensitization, circumventing multidrug resistance, normal tissue radioprotection, and antiangiogenesis have been examined extensively. However, potential molecular mechanisms effect glioma are yet...
// Fucheng Zhou 1, * , Yang Li Zhen Hao 1 Xuanxi Liu Liang Chen Yu Cao Zuobin Fei Yuan Jie Jianjiao Wang Yongri Zheng Deli Dong 2 Shan Bian 3 Baofeng Chuanlu Jiang Qingsong Department of Neurosurgery, The 2nd Affiliated Hospital, Harbin Medical University, 150086, China Institute Molecular Biology, Austrian Academy Sciences, Vienna, Austria These authors have contributed equally to this work Correspondence to: Li, email: qing1songli@sina.com Jiang, jiangchuanlu123@sina.com Yang,...
Bis-naphtho-γ-pyrones (BNPs) are an important group of aromatic polyketides derived from fungi, and asperpyrone-type BNPs produced primarily by Aspergillus species. The fungal strain niger SCSIO Jcsw6F30, isolated a marine alga, Sargassum sp., identified according to its morphological traits the internal transcribed spacer (ITS) region sequence, was studied for secondary metabolisms. After HPLC/MS analysis crude extract fermentation broth, 11 were obtained directly quickly chromatographic...
In the microchip electrophoresis with capacitively coupled contactless conductivity detection, stray capacitance of detector causes high background noise, which seriously affects sensitivity and stability detection system. To reduce effect, a novel design planar grounded (PG-C4D) based on printed circuit board (PCB) is proposed. The entire plane except sensing electrodes covered by ground electrode, greatly reducing capacitance. efficacy has been verified electrical field simulation...
Abstract Glioma (GM) is a highly lethal human cancer. Circular RNAs (circRNAs) act as an imperative factor in oncogenesis. We aimed to investigate the biological functions and mechanisms of circ‐CDC45 GM. expression GM specimens cell lines was measured by real‐time quantitative reverse transcription polymerase chain reaction. Fisher's exact test Kaplan‐Meier curves further analyzed its clinical implications. A gain/loss‐of‐function study conducted role Additionally, luciferase reporter...
Evidence has revealed that long non-coding RNAs (lncRNAs) are involved in carcinogenesis and tumor progression. lncRNAs play an important role regulation of numerous cellular processes including cell proliferation, apoptosis, cycle, differentiation, motility. Several studies have demonstrated lncRNA EPIC1 governs growth, migration, invasion, drug resistance human malignancies. However, the its underlying molecular mechanisms glioma not been investigated. In this study, we determined function...
Seven unusual new ene-yne hydroquinones (1–3, 5–8), including three rare glycosylated derivatives named pestalotioquinosides A–C (6–8), were obtained from the marine-derived strain SCSIO41403 of fungus Pestalotiopsis neglecta. Their structures absolute configurations elucidated by spectroscopic analysis and induced electronic circular dichroism experiments. In silico molecular docking in vitro surface plasmon resonance studies showed that pestalotioquinoside C (8) could act as a liver X...
Microchip electrophoresis (ME) is an ion detection system with low cost and portability, which suitable for online analysis of environmental samples.However, the unresolved peaks in signal complex samples seriously affect measurement accuracy sample concentration.In this article, efficient algorithm proposed, based on sigmoidal membership function, Lévy flight, slime mould (SLSMA).First, hyperbolic tangent function original (SMA) replaced by to enhance global optimization capability.Second,...
Two novel sorbicillinoid adducts containing bicyclo[2.2.2]octane and tetrahydrofuran moieties, named sorbicillfurans A B (<bold>1</bold> <bold>2</bold>), were isolated from the static culture of marine-derived fungus <italic>Penicillium citrinum</italic> SCSIO41402.
Accumulating evidence suggests that microRNAs (miRNAs) play a key role in the biological behaviors and progression of glioma. However, function bio‑molecular mechanisms miR‑342 glioma remain largely unclear. In present study, reverse transcription quantitative‑polymerase chain reaction western blotting were performed to determine mRNA protein expression levels factors investigated. MTT assay was examine proliferation rates. Luciferase reporter test binding between miRNA‑342 its putative...
Subarachnoid hemorrhage (SAH) is a severe neurological disease, which associated with significant number of cases premature mortality and disability worldwide. Mild hypothermia (MH) has been proposed as potential therapeutic strategy to reduce neuronal injury following SAH. The present study aimed investigate the mechanisms MH's protective role in process demonstrated that MH was able protect against early brain rat model Treating SAH rats reduced release reactive oxygen species prevented...