A5048667355- Viral Infectious Diseases and Gene Expression in Insects
- Invertebrate Immune Response Mechanisms
- Protein purification and stability
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Bacteriophages and microbial interactions
- Neurobiology and Insect Physiology Research
- Hepatitis B Virus Studies
- 3D Printing in Biomedical Research
- Virus-based gene therapy research
- Insect Resistance and Genetics
- Hydrogels: synthesis, properties, applications
- Monoclonal and Polyclonal Antibodies Research
- Nanoparticle-Based Drug Delivery
- Electrospun Nanofibers in Biomedical Applications
- Aquaculture disease management and microbiota
- Garlic and Onion Studies
- Insect symbiosis and bacterial influences
- Glycosylation and Glycoproteins Research
- Immunotherapy and Immune Responses
- Catalytic Processes in Materials Science
- Graphene and Nanomaterials Applications
- Cellular Mechanics and Interactions
- Viral gastroenteritis research and epidemiology
- Luminescence Properties of Advanced Materials
Shandong Academy of Agricultural Sciences
2021-2025
Ministry of Agriculture and Rural Affairs
2025
Zhujiang Hospital
2025
Southern Medical University
2025
The University of Adelaide
2015-2024
Nanjing Normal University
2016-2023
University of Missouri
2021-2023
Jiangyin People's Hospital
2018
Case Western Reserve University
2016
Cornell University
2016
Functionalized dendrimer-like hybrid silica nanoparticles with hierarchical pores are designed and synthesized. The unique structure, large surface area, excellent biocompability render such materials attractive nanocarriers for the advanced delivery of various sized drugs genes simultaneously.
MXenes, a new family of two-dimensional transition metal carbides/nitrides, have been exploited in 3D bioprinting owing to their outstanding properties such as large specific surface area, high electrical conductivity, and biodegradability.
A novel type of magnetic core–shell silica nanoparticles is developed for small interfering RNA (siRNA) delivery. These are fabricated by coating super‐paramagnetic magnetite nanocrystal clusters with radial large‐pore mesoporous silica. The amine functionalized have particle sizes around 150 nm, large mesopores 12 surface area 411 m 2 g −1 , high pore volume 1.13 cm 3 and magnetization 25 emu . Thus, these possess both loading capacity siRNA (2 wt%) strong response under an external field....
Bioprinting is an emerging powerful fabrication method, which enables the rapid assembly of 3D bioconstructs with dispensing cell-laden bioinks in pre-designed locations.
Abstract Chinese hamster ovary cells have been engineered to inducibly over‐express the p21 CIP1 cyclin‐dependent kinase inhibitor, achieve cell cycle arrest and increase productivity. In ‐arrested production of antibody from a stably integrated lgG4 gene, was enhanced approximately fourfold. The underlying physiological basis for productivity investigated by measuring range cellular metabolic parameters. Interestingly, average volume arrested fourfold greater than that proliferating cells....
ABSTRACT Mimicking the zonal organization of native articular cartilage, which is essential for proper tissue functions, has remained a challenge. In this study, thermoresponsive copolymer chitosan‐g‐poly(N‐isopropylacrylamide) (CS‐g‐PNIPAAm) was synthesized as carrier mesenchymal stem cells (MSCs) to provide support their proliferation and differentiation. Microengineered three‐dimensional (3D) cell‐laden CS‐g‐PNIPAAm hydrogels with different microstripe widths were fabricated control...
Tunable stellate mesoporous silica nanoparticles are functionalized with low molecular poly(ethylene imine) for efficient label-free intracellular drug delivery.
Chitosan shows good biocompatibility and biodegradability, but the poor water solubility low transfection efficiency hinder its applications as a gene delivery vector. We here report detailed synthesis characterization of novel ampholytical chitosan derivative, N-imidazolyl-O-carboxymethyl (IOCMCS), used for high performance delivery. After chemical modification, resulting polymer is enhanced, soluble in wide pH range (4-10). Gel electrophoresis study reveals strong binding ability between...
Providing a controllable and definable three-dimensional (3D) microenvironment for chondrogenic differentiation of mesenchymal stem cells (MSCs) remains great challenge cartilage tissue engineering. In this work, poly(N-isopropylacrylamide) (PNIPAAm) polymers with the degrees polymerization 100 400 (NI100 NI400) were prepared polymer solutions introduced into preprepared chitosan porous scaffolds (CS) to form hybrids (CSNI100 CSNI400, respectively). SEM images indicated that PNIPAAm gel...
Cuticle is not only critical for protecting insects from noxious stimuli but also involved in a variety of metabolic activities. Cuticular proteins (CPs) affect cuticle structure and mechanical properties during insect growth, reproduction, environmental adaptation. Here, we describe the identification characterization member RR-1 subfamily CPs with an R&R consensus (CPR) Tribolium castaneum (TcCPR69). Although it was previously reported to be highly expressed wings, found that knocking down...
ABSTRACT Hematodinium perezi , a pathogenic dinoflagellate, is one of major epidemiological agents that lead to severe losses cultured marine crustaceans in China. This study aimed develop novel, sensitive and specific detection method qualified for early surveillance control the disease caused by H. . The present established TaqMan‐MGB probe quantitative PCR (qPCR) method, targeting first internal transcribed spacer 1 (ITS 1) region optimising reaction components. A high correlation...
γ-l-Glutamyl-S-allyl-l-cysteine (GSAC) is renowned for its flavor-modifying effects and beneficial biological activities. However, the level of GSAC decreases significantly during processing black garlic, pathways degradation products resulting from this decline remain unclear. To investigate potential transformation mechanisms in simulation systems thermal decomposition, Maillard reactions, enzymatic hydrolysis were established. In addition to fructose, a total 6 identified confirmed....