A5058224205- Receptor Mechanisms and Signaling
- Chemical Synthesis and Analysis
- Estrogen and related hormone effects
- Sphingolipid Metabolism and Signaling
- Peptidase Inhibition and Analysis
- Lipid Membrane Structure and Behavior
- Enzyme Structure and Function
- Chemokine receptors and signaling
- Nicotinic Acetylcholine Receptors Study
- Cardiac electrophysiology and arrhythmias
- Asthma and respiratory diseases
- Microfluidic and Capillary Electrophoresis Applications
- bioluminescence and chemiluminescence research
- Ion channel regulation and function
- Protein Structure and Dynamics
- Mass Spectrometry Techniques and Applications
Moscow Institute of Physics and Technology
2019-2023
Lomonosov Moscow State University
2016
Two distinct antagonist-bound structures of CysLT 1 R reveal unique ligand-binding modes and signaling mechanisms.
The bioactive lysophospholipid sphingosine-1-phosphate (S1P) acts via five different subtypes of S1P receptors (S1PRs) - S1P1-5. S1P5 is predominantly expressed in nervous and immune systems, regulating the egress natural killer cells from lymph nodes playing a role neurodegenerative disorders, as well carcinogenesis. Several S1PR therapeutic drugs have been developed to treat these diseases; however, they lack receptor subtype selectivity, which leads side effects. In this article, we...
Abstract Structural studies of challenging targets such as G protein-coupled receptors (GPCRs) have accelerated during the last several years due to development new approaches, including small-wedge and serial crystallography. Here, we describe deposition seven datasets consisting X-ray diffraction images acquired from lipidic cubic phase (LCP) grown microcrystals two human GPCRs, Cysteinyl leukotriene 1 2 (CysLT R CysLT R), in complex with various antagonists. Five were collected using...
ABSTRACT The bioactive lysophospholipid sphingosine-1-phosphate (S1P) acts via five different subtypes of S1P receptors (S1PR) - 1-5 . 5 is predominantly expressed in nervous and immune systems, regulating the egress natural killer cells from lymph nodes playing a role neurodegenerative disorders, as well carcinogenesis. Several S1PR therapeutic drugs have been developed to treat these diseases; however, they lack receptor subtype selectivity, which leads side effects. In this article, we...