A5046965356- Asthma and respiratory diseases
- Air Quality and Health Impacts
- Copper Interconnects and Reliability
- Semiconductor materials and devices
- Noise Effects and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- IL-33, ST2, and ILC Pathways
- Indoor Air Quality and Microbial Exposure
- Glutathione Transferases and Polymorphisms
- Pediatric health and respiratory diseases
- Endodontics and Root Canal Treatments
- 3D IC and TSV technologies
- Immune Cell Function and Interaction
- Hearing, Cochlea, Tinnitus, Genetics
- Geological and Geophysical Studies
- Peptidase Inhibition and Analysis
- Pregnancy and preeclampsia studies
- Inflammatory mediators and NSAID effects
- Genomics, phytochemicals, and oxidative stress
- Insect symbiosis and bacterial influences
- Smoking Behavior and Cessation
- Skin Protection and Aging
- Per- and polyfluoroalkyl substances research
- Hemoglobinopathies and Related Disorders
- Toxic Organic Pollutants Impact
National Taiwan University
2012-2025
Institute of Biomedical Sciences, Academia Sinica
2020-2025
National Taiwan University Hospital
2019-2024
National Central University
2023
Taiwan Semiconductor Manufacturing Company (Taiwan)
2011-2023
Paracelsus Medical University
2019
Cancer Research Institute of the Slovak Academy of Sciences
2019
China Medical University Hospital
2000-2018
China Medical University
2000-2018
Taiwan Semiconductor Manufacturing Company (United States)
2012-2015
Perfluorinated compounds (PFCs) are ubiquitous pollutants. Experimental data suggest that they may be associated with adverse health outcomes, including asthma. However, there is little supporting epidemiological evidence.A total of 231 asthmatic children and 225 nonasthmatic controls, all from northern Taiwan, were recruited in the Genetic Biomarkers study for Childhood Asthma. Structure questionnaires administered by face-to-face interview. Serum concentrations 11 PFCs levels immunological...
Although studies show that maternal smoking during pregnancy increases the risks of respiratory outcomes in childhood, evidence concerning effects household environmental tobacco smoke (ETS) exposure remains inconsistent. We conducted a population-based study comprised 5,019 seventh and eighth-grade children 14 Taiwanese communities. Questionnaire responses by parents were used to ascertain children's disease status. Logistic regression models fitted estimate ETS exposures on prevalence...
The feasibility of genetic screening for deafness-causing mutations in newborns has been reported several studies. aim this study was to investigate the long-term results those who screened positive deafness mutations; these are crucial determine cost-effectiveness justify population-wide screening.We performed simultaneous hearing and targeting four common (p.V37I c.235delC GJB2, c.919-2A>G SLC26A4, mitochondrial m.1555A>G) 5173 at a tertiary hospital between 2009 2015. Serial audiometric...
The association between neutrophil extracellular traps (NETs) and response to inhaled corticosteroids (ICS) in asthma is unclear. To better understand this relationship, we analyzed the blood transcriptomes from children with controlled uncontrolled Taiwanese Consortium of Childhood Asthma Study using weighted gene coexpression network analysis pathway enrichment methods. We identified 298 asthma-specific differentially expressed genes one module associated neutrophil-mediated immunity,...
Background The importance of gene-gene and gene-environment interactions on asthma is well documented in literature, but a systematic analysis the interaction between various genetic environmental factors still lacking. Methodology/Principal Findings We conducted population-based, case-control study comprised seventh-grade children from 14 Taiwanese communities. A total 235 asthmatic cases 1,310 non-asthmatic controls were selected for DNA collection genotyping. examined 17 single-nucleotide...
Abstract Background Respiratory syncytial virus (RSV) infection is epidemiologically linked to asthma. During RSV infection, IL‐33 elevated and promotes immune cell activation, leading the development of However, which cells are responsible for triggering airway hyperreactivity (AHR), inflammation eosinophilia remained be clarified. We aimed elucidate individual roles IL‐33‐activated innate cells, including ILC2s ST2 + myeloid in infection‐triggered pathophysiology. Methods The role...
Childhood asthma comprises different phenotypes with complex pathophysiology. Different evoke various clinical symptoms and vary in their responses to treatments.We applied k-means clustering algorithm of twelve objective laboratory tests among 351 asthmatic children enrolled the Taiwanese Consortium Asthma Study (TCCAS). We constructed gene expression profiles peripheral blood mononuclear cells (PBMC) from phenotypes.Five distinct childhood were identified can be characterized by either...
Incense burning is a popular practice in many family homes and temples. However, little known about the effects of indoor incense genetic polymorphisms on asthma. This study evaluated glutathione S -transferase (GST) asthma wheeze. In 2007, 3,764 seventh-grade schoolchildren (mean± sd age 12.42±0.65 yrs) were using standard questionnaire for information respiratory symptoms environmental exposures. Multiple logistic regressions performed to assess association between GST frequency wheeze,...
<title>Abstract</title> Anecdotal evidence has suggested an association between psychiatric drugs and psoriasis but consensus is absent due to contradicting reports the mechanism remains poorly defined. Here, we investigated role played by serotonin 2A receptor (HTR2A), a commonly targeted drugs, in regulating psoriasis. HTR2A antagonistic worsened psoriatic outcome modulation reduced inflammation. Using Imiquimod-induced psoriasiform model, HTR2A-deficient mice experienced exacerbated...
During meiosis, programmed DNA double-strand breaks (DSBs) are formed at hotspots to initiate homologous recombination, which is vital for reassorting genetic material. In fission yeast, the linear element (LinE) proteins Mug20, Rec25, and Rec27 interdependently bind chromosomal with high specificity necessary high-level DSB formation. However, their mechanistic role in regulating meiotic machinery remains unknown. Here, using purified Mug20-Rec25-Rec27 (MRR) complex functional intracellular...
Abstract Saponin-based adjuvants (SBA), such as QS-21, show profound abilities to enhance antibody production well activate cellular immunity. They are being used in more than 70 cancer vaccines clinical trials, particularly due the nature of activated immune response; however, only a few evidence was given SBA could modulate antigen cross-presentation dendritic cells CD8+ T-cell response. It is still elusive how SBAs promote cross-priming vivo comprehensively. Our study has shown that...
Summary Background Previous studies have defined transcriptomic subtypes of adult asthma using samples induced sputum and bronchial epithelium; however, those procedures are not readily applicable in the clinic, especially for childhood asthma. Objective We aim to dissect clusters highly variably expressed genes peripheral blood mononuclear cells ( PBMC ) among patients. Methods Gene expression from 133 asthmatic children 11 healthy controls was measured with Illumina microarrays. applied...
There is growing evidence that multiple genes and air pollutants are associated with asthma. By identifying the effect of pollution on general population, effects childhood asthma can be better understood. We conducted Taiwan Children Health Study (TCHS) to investigate influence gene–air interactions Complete monitoring data for ambient were collected from Environmental Protection Agency stations. Our results show a significant two-way interaction between glutathione S-transferase P (GSTP1)...
Abstract Background Nonsteroidal anti‐inflammatory drugs (NSAIDs) such as acetylsalicylic acid (ASA, aspirin) are well known chemotherapeutic agents of cancers; however, the signalling molecules involved remain unclear. The aim this study was to investigate possible existence a putative p53‐dependent pathway underlying ASA‐induced apoptosis in OC2 cells, human oral cancer cell line. Materials and methods methyl tetrazolium (MTT) assay employed quantify differences viability. DNA ladder...
Background There are limited studies on the role of interaction between exposure to ambient air pollution and glutathione-S-transferase (GST) P1 risk asthma/wheezing among children, which provided suggestive, but inconclusive results. Methods To assess joint effect pollutants GSTP1 asthma/wheezing, we conducted a nationwide cross-sectional study 3,825 children in Taiwan Children Health Study. The studied determinants were three Ile105Val (rs 1695) genotypes (Ile-Ile; Ile-Val Val-Val) expoure...
Abstract Objectives To assess and compare the ejection fraction (EF) shortening (SF) of both ventricles through pregnancy. Materials Uncomplicated singleton pregnancies, between 10 40 weeks' gestation, were recruited. Transabdominal two‐dimensional M‐mode imaging right ventricular EF (REF), SF (RSF), left (LEF), (LSF) performed. Doppler surveys performed at (1) 10–14 weeks; (2) 15–19 (3) 20–24 (4) 25–29 (5) 30–34 (6) 35–40 weeks. The following values measured: REF, RSF, LEF, LSF, REF/LEF...
Two fully self-aligned via (SAV) integration schemes by metal recess approach and area-selective dielectric-on-dielectric (DoD) method are reported in this paper. A topography with enlarged diagonal distance is essential for the vias to be self-aligned. The encounters challenge of poor uniformity, high surface roughness, degraded integrity. DoD featuring an upward dielectric terrace deposited selective-SAM-blocking shows two orders magnitude improvement via-to-line time dependent breakdown...
Objectives Environmental exposure at home, such as dampness, has been shown to have adverse effects on respiratory health. However, few studies explored the association between home dampness and genetic polymorphisms childhood asthma. The aim of study is evaluate tumour necrosis factor-α gene ( TNF-α ) asthma in Taiwanese children. Methods authors investigated 3810 schoolchildren Taiwan Children Health Study from 14 communities. Children's disease status were measured a parental...