A5003583200- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Per- and polyfluoroalkyl substances research
- Sarcoma Diagnosis and Treatment
- RNA modifications and cancer
- Air Quality and Health Impacts
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Single-cell and spatial transcriptomics
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Reproductive System and Pregnancy
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Brain Metastases and Treatment
- Cancer Cells and Metastasis
- Heavy Metal Exposure and Toxicity
- Birth, Development, and Health
- Cancer-related Molecular Pathways
- Plant and Fungal Interactions Research
- Neuroscience of respiration and sleep
- Toxic Organic Pollutants Impact
Duke University
2020-2025
Guangzhou Medical University
2022-2025
Duke Cancer Institute
2018-2023
Duke Medical Center
2018-2022
Duke University Hospital
2021
Vancouver Clinic
2020
Washington State University Vancouver
2020
Lund University
2020
Durham Technical Community College
2020
Cancer Institute (WIA)
2018-2019
Little information exists regarding the effect of interaction obesity and long-term air pollution exposure on children's blood pressure hypertension in areas with high levels pollution. The aim this study is to assess modification by association between Chinese children.We studied 9,354 children, ages 5-17 years old, from 24 elementary schools middle Seven Northeastern Cities during 2012-2013. Four-year average concentrations particles an aerodynamic diameter ≤10 µm (PM10), sulfur dioxide,...
Abstract Immunotherapy fails to cure most cancer patients. Preclinical studies indicate that radiotherapy synergizes with immunotherapy, promoting radiation-induced antitumor immunity. Most preclinical immunotherapy utilize transplant tumor models, which overestimate patient responses. Here, we show sarcomas are cured by PD-1 blockade and radiotherapy, but identical treatment in autochthonous sarcomas, demonstrate immunoediting, decreased neoantigen expression, tumor-specific immune...
Most prostate cancers express the androgen receptor (AR), and tumor growth progression are facilitated by exceptionally low levels of systemic or intratumorally produced androgens. Thus, absolute inhibition signaling axis remains goal current therapeutic approaches to treat cancer (PCa). Paradoxically, high dose androgens also exhibit considerable efficacy as a treatment modality in patients with late-stage metastatic PCa. Here we show that androgens, functioning through an AR monomer,...
Cancer development is influenced by hereditary mutations, somatic mutations due to random errors in DNA replication, or external factors. It remains unclear how distinct cell-intrinsic and -extrinsic factors affect oncogenesis within the same tissue type. We investigated murine soft-tissue sarcomas generated oncogenic alterations (KrasG12D activation p53 deletion), carcinogens (3-methylcholanthrene [MCA] ionizing radiation), both a potentially novel model (MCA plus deletion). Whole-exome...
Abstract Changes in gene expression lung epithelial cells are detected cancer tissues during exposure to pollutants, highlighting the importance of gene‐environmental interactions disease. Here, a Cd‐induced malignant transformation model mouse lungs and bronchial cell lines is constructed, differences non‐coding circRNAs analyzed. The migratory invasive abilities Cd‐transformed suppressed by circCIMT. A significant DNA damage response observed after Cd, which increased further following...
Estrogens play a critical role in parturition, and poly- perfluoroalkyl substances (PFAS), which have estrogenic effects, been associated with preterm birth. However, the impact of estrogens on association between PFAS birth is unknown.The objective this study to investigate if modified birth, using nested case-control design.A total 371 births 508 controls were selected from cohort China 2016 2018. Perfluorobutanoic acid (PFBA), perfluorohexanesulfonic (PFHxS) its branched isomer,...
The APOBEC family of cytidine deaminases is one the most common endogenous sources mutations in human cancer. Genomic studies tumors have found that mutational signatures are enriched HER2 subtype breast cancer and associated with immunotherapy response diverse types. However, direct consequences mutagenesis on tumor immune microenvironment not been thoroughly investigated. To address this, we developed syngeneic murine mammary models inducible expression APOBEC3B. We activity induced...
A homogeneous iMS biosensor allows for the discrimination of esophageal cancer tissue from normal <italic>via</italic> detection microRNA biomarkers within clinical samples.
Alloreactivity can drive autoimmune syndromes. After allogeneic hematopoietic stem cell transplantation (allo-HCT), chronic graft-versus-host disease (cGVHD), a B cell–associated autoimmune-like syndrome, commonly occurs. Because donor-derived cells continually develop under selective pressure from host alloantigens, aberrant receptor (BCR) activation and IgG production emerge contribute to cGVHD pathobiology. To better understand molecular programing of in allo-HCT, we performed scRNA-Seq...
Abstract Ductal carcinoma in situ (DCIS) is a risk factor for subsequent invasive breast cancer. To identify events DCIS that lead to cancer, we performed single-cell RNA-sequencing (scRNA-seq) on lesions and matched normal tissue. Inferred copy number variation (CNV) was used neoplastic epithelial cells from clinical specimens, which contained mixture of ducts. Phylogenetic analysis demonstrated intratumoral clonal heterogeneity associated with significant gene expression differences....
Abstract Background Brain metastases (BrM) arising from breast cancer (BC) are an increasing consequence of advanced disease, with up to half patients metastatic HER2 + or triple negative BC experiencing central nervous system (CNS) recurrence. The genomic alterations driving CNS recurrence, along contributions the immune microenvironment, particularly by intrinsic subtype, remain unclear. Methods We characterized and landscape BCBrM a cohort 42 sequencing whole-exome DNA (WES) total RNA...
Abstract Some cancers are strongly associated with exposure to environmental carcinogens, and genetic epigenetic alterations crucial in carcinogenesis. However, the interaction between mutations regulation cancer development has not been sufficiently examined. Here, we investigated roles of gene altered circRNA expression malignant transformation human bronchial epithelial cells after continuous CdCl2 (10 μM). The circular RNA circ_0007095 was down-regulated, SETBP1-R54P single nucleotide...
Hypercapnia develops in one third of patients with advanced chronic obstructive pulmonary disease (COPD) and is associated increased morbidity mortality. Multiple factors COPD are thought to contribute the development hypercapnia including carbon dioxide (CO2) production, dead space ventilation, complex interactions deranged respiratory system mechanics, inspiratory muscle overload ventilatory control center brainstem. However, these have not previously been systematically analyzed a large,...
Little information exists about the evaluation of potential developmental immunotoxicity induced by perfluorooctane sulfonate (PFOS), a synthetic persistent and increasingly ubiquitous environmental contaminant. To assess sex-specific impacts PFOS on immunological health in offspring, using male female C57BL/6 mice, pups were evaluated for immunotoxic effects after maternal oral exposure to (0.1, 1.0 5.0 mg PFOS/kg/day) during Gestational Days 1–17. Spontaneous TH1/TH2-type cytokines, serum...
Soft-tissue sarcomas (STS) are rare malignancies showing lineage differentiation toward diverse mesenchymal tissues. Half of all high-grade STSs develop lung metastasis with a median survival 15 months. Here, we used genetically engineered mouse model that mimics undifferentiated pleomorphic sarcoma (UPS) to study the molecular mechanisms driving metastasis. High-grade were generated Cre recombinase technology using mice conditional mutations in
Background There is growing interest in the joint effects of hazardous trace elements (HTEs) on lung function deficits, but data are limited. This a critical research gap given increased global industrialisation. Methods A national cross-sectional study including spirometry was performed among 2112 adults across 11 provinces China between 2020 and 2021. total 27 HTEs were quantified from urine samples. Generalised linear models quantile-based g-computation used to explore individual urinary...
There is little information about how exposure to pets impacts blood pressure (BP) in children. The objective of the present study was investigate association between pet and BP children.A total 9354 children, aged 5-17 years, from 24 elementary schools middle Seven Northeastern Cities were evaluated during 2012-2013. measurements taken using a mercury sphygmomanometer. Hypertension children defined as having an average DBP or SBP 95th percentile higher for child's sex, age, height.Overall,...
Cellular responses to DNA damage and other stresses are important determinants of mutagenesis impact the development a wide range human diseases. TP53 is highly mutated in cancers plays an essential role stress cell fate determination. A central dogma p53 induction after has been that results from transient increase half-life protein. Our laboratory recently demonstrated this long-standing paradigm incomplete picture regulation by uncovering critical for protein translational damage. These...
Abstract Mouse models of radiation-induced thymic lymphoma are widely used to study the development blood cancers and gain insights into biology human T-cell lymphoblastic leukemia/lymphoma. Here we aimed identify key oncogenic drivers for by performing whole-exome sequencing using tumors paired normal tissues from mice with without irradiation. Thymic lymphomas irradiated wild-type (WT), p53+/−, KrasLA1 were not observed harbor significantly higher numbers nonsynonymous somatic mutations...