A5042736783- Substance Abuse Treatment and Outcomes
- Immune Cell Function and Interaction
- Alcohol Consumption and Health Effects
- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Gambling Behavior and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Glycosylation and Glycoproteins Research
- Schizophrenia research and treatment
- Neurotransmitter Receptor Influence on Behavior
- Mental Health Research Topics
- Mental Health Treatment and Access
- T-cell and B-cell Immunology
- Health disparities and outcomes
National Taiwan University
1986-2019
Institute of Biomedical Sciences, Academia Sinica
2018-2019
Taipei Medical University
2018-2019
Bali Psychiatric Center
1991
Childhood asthma comprises different phenotypes with complex pathophysiology. Different evoke various clinical symptoms and vary in their responses to treatments.We applied k-means clustering algorithm of twelve objective laboratory tests among 351 asthmatic children enrolled the Taiwanese Consortium Asthma Study (TCCAS). We constructed gene expression profiles peripheral blood mononuclear cells (PBMC) from phenotypes.Five distinct childhood were identified can be characterized by either...
Summary Background Previous studies have defined transcriptomic subtypes of adult asthma using samples induced sputum and bronchial epithelium; however, those procedures are not readily applicable in the clinic, especially for childhood asthma. Objective We aim to dissect clusters highly variably expressed genes peripheral blood mononuclear cells ( PBMC ) among patients. Methods Gene expression from 133 asthmatic children 11 healthy controls was measured with Illumina microarrays. applied...
ABSTRACT The prevalence of alcoholism was reported to be 0.1 % in an aboriginal study on Taiwan using the census survey method 1950s. This adopted a modified Chinese Diagnostic Interview Schedule determine DSM‐III‐defined alcohol abuse (AA) and dependence (AD) Atayal, Paiwan Yami ethnic groups aborigines. Stratified random sampling used. sample sizes were 793, 656 106 respectively. rates AA AD 11.6%, 11.4% 14.2%; 9.0%, 8.1% 6.4% No significant difference found between 3 groups. These figures...
The validity of DIS-CM (Chinese modified version Diagnostic Interview Schedule) was examined by analyzing lifetime prevalence each age group, at onset, and recency illness. magnitude the discrepancy between empirical estimated data adopted as criterion degree deviation. Manic depressive episodes were found to be seriously underestimated. Schizophrenic, panic, phobic antisocial personality disorders probably observed figures with are rather conservative for these disorders. a recent 1-year...
A community survey in metropolitan Taipei (MT) and two small towns (ST) by using the Chinese modified diagnostic interview schedule (DIS-CM) revealed a significant difference prevalence of alcohol abuse (AA) defined DSM-III between study samples (MT 3.4%; ST 8.0%), but dependence (AD) was not different 1.5%; 1.8%). These figures are significantly higher than that an earlier Formosan study. Demographic data, psychiatric symptoms, medical complications impairment social functions were adopted...
Abstract Memory T helper (Th) and regulatory (Treg) cells play key roles in asthma. Certain sialyl carbohydrate determinants for selectins profoundly affect the migratory properties of memory Th cells, suppressive function Treg cells. Previous studies have shown that proportion CCR4 + expressing 6-sulfo Lewis X (Le ) is elevated asthma patients. We aim to investigate different glycans on cell subsets Using flow cytometry, we assessed expression three glycans, Le , cyclic peripheral blood...
The objective of this study was to explore possible risk factors alcohol abuse (AA) and dependence (AD), as defined by DSM‐III criteria, in Taiwan aborigines. a sample 1555 aborigines were analyzed using the chi‐square test multivariate logistic regression statistics. showed that AD are being male, having relatively little education, involved problem marriage, laborer, part couple with drinking problem, positive family history alcoholism. AA has ethnic subgroups dwelling main Island, poor...