A5007957123- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- MicroRNA in disease regulation
- RNA Research and Splicing
- Circular RNAs in diseases
- Gut microbiota and health
- Ubiquitin and proteasome pathways
- Esophageal Cancer Research and Treatment
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Stroke Rehabilitation and Recovery
- RNA and protein synthesis mechanisms
- Cancer, Hypoxia, and Metabolism
- Liver physiology and pathology
- Peptidase Inhibition and Analysis
- RNA Interference and Gene Delivery
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral-associated cancers and disorders
- Wnt/β-catenin signaling in development and cancer
- Molecular Biology Techniques and Applications
- Gastroesophageal reflux and treatments
- Glioma Diagnosis and Treatment
- Genomics and Chromatin Dynamics
Fudan University
2025
Zhongshan Hospital of Xiamen University
2023-2025
Huazhong University of Science and Technology
2025
Southeast University
2015-2024
Second Hospital of Anhui Medical University
2021-2024
Anhui Medical University
2021-2024
Shaoxing People's Hospital
2014-2023
Shaanxi Normal University
2022
Second Military Medical University
2018-2021
Shanghai Changzheng Hospital
2020-2021
OBJECTIVES: Elucidating the minimal hepatic encephalopathy (MHE)-associated gut microbiome may help in predicting and lowering high risk for MHE patients with cirrhosis. METHODS: Twenty-six were recruited screened from among those liver cirrhosis without overt as defined by abnormality seen on two test modalities: number connection part A digit symbol test. Using 26 MHE-matched normal relatives 25 cirrhotic controls, means of 16S ribosomal RNA (rRNA)-based pyrosequencing, we examined...
Abstract It is well accepted that HBx plays the major role in hepatocarcinogenesis associated with hepatitis B virus (HBV) infections. However, little was known about its regulating long noncoding RNAs (lncRNAs), a large group of transcripts variety biological processes including carcinogenesis mammalian cells. Here we report upregulates UCA1 genes and downregulates p27 hepatic LO2 Further studies show upregulated promotes cell growth by facilitating G1/S transition through CDK2 both...
Abstract Background The aim of this study is to expand existing knowledge about the CRC-associated microbiome among Han Chinese, and further discover variation pattern human CRC across all population. Findings Using pyrosequencing-based molecular monitoring bacterial 16S rRNA gene from eight tumor/normal tissue pairs Chinese patients, we analyzed characterized basic features microbiome. Firstly, discovered an increasing diversity tumor-associated communities. Secondly, in 50% found a...
Abstract Increasing studies showed that long-noncoding RNAs (lncRNAs) play important roles in the biological processes, including cancer initiation and progression. However, little is known about exact role regulation mechanism of lncRNA UCA1 during progression gastric (GC). In this study, we found was aberrantly elevated tissues, significantly associated with lymph node metastasis TNM stage. vivo vitro, enforced level promoted cell migration invasion GC cell. Depleted expression attenuated...
DNA-methyltransferase (DNMT)-3A plays an important role in the development of embryogenesis and generation aberrant methylation carcinogenesis. The aim this study was to investigate a DNMT3A promoter genetic variant on its transcriptional activity evaluate association between gene polymorphism susceptibility gastric cancer (GC) oesophagus carcinoma (EC) Chinese population. We selected one single nucleotide polymorphisms (SNPs) -448A>G region evaluated effect using luciferase assay. were...
Both genetic and epigenetic alterations have been reported to act as driving forces of tumorigenesis in colorectal cancer (CRC), but a growing body evidence suggests that intestinal microbiota may be an aetiological factor the initiation progression CRC. Recently, "driver-passenger" model for CRC has connected these different factors, little done characterize gut microbiome.Building on driver-passenger model, we used 454 pyrosequencing bacterial 16S rRNA genes associated with 10 normal,...
Gastric cancer (GC) is the second common cause of cancer-related death worldwide. Long noncoding RNAs (lncRNAs) are emerging as novel regulators in paradigm. However, investigation lncRNAs on GC still its infancy. In this study, we focused lncRNA SPRY4 intronic transcript 1 (SPRY4-IT1) and investigated expression pattern, clinical significance, biological function, molecular mechanism GC. SPRY4-IT1 was examined, correlation with clinicopathological characteristics patient prognosis analyzed....
DNA methyltransferase 3A (DNMT3A) has been recognised as a key element of epigenetic regulation in normal development, and the aberrant DNMT3A is implicated multiple types cancers, especially haematological malignancies. However, its clinical significance detailed functional role solid tumours remain unknown, although abnormal expression gained widespread attention these cancers. Here, we show that isoform b (DNMT3Ab), member family, critical for directing epithelial–mesenchymal transition...
Hepatocellular carcinoma (HCC) is among the most common malignancies and has an unfavorable prognosis. The hepatitis B virus-encoded X (HBx) protein closely associated with hepatocarcinogenesis. Sorafenib a unique targeted oral kinase inhibitor for advanced HCC. Long noncoding RNAs (lncRNAs) mediate HCC progression therapeutic resistance by acting as competing endogenous (ceRNAs). However, ceRNA regulatory mechanisms underlying sorafenib in HBx-associated remain largely unknown. In this...
Hepatitis B virus (HBV) infection is the predominant causes of hepatocellular carcinoma (HCC). HBV X protein (HBx), as most frequently integrated viral gene sequence following infection, plays a critical role in pathogenesis HCC. H3K27ac characteristic marker for identifying active enhancers and even indicates chromatin accessibility associated with super-enhancers (SEs). In this study, ChIP-seq was applied high-quality SE annotation HBx-induced SEs evaluation. The results indicated that HBx...
ALYREF is considered as a specific mRNA m5C-binding protein which recognizes m5C sites in RNA and facilitates the export of from nucleus to cytoplasm. Expressed various tissues highly involved transcriptional regulation, has potential become novel diagnostic marker therapeutic target for cancer patients. However, few studies focused on its function during carcinogenesis progress. In order explore role tumorigenesis, TCGA GTEx databases were used investigate relationship pan-cancer. We found...
Promoter hypermethylation mediated by DNA methyltransferases (DNMTs) is the main reason for epigenetic inactivation of tumor suppressor genes (TSGs). Previous studies showed that DNMT1 and DNMT3B play an important role in CpG island methylation tumorigenesis. Little known about DNMT3A this process, especially hepatocellular carcinoma (HCC). In present study, increased expression 3 out 6 HCC cell lines 16/25 (64%) tissues implied involved carcinogenesis. Depletion line SMMC-7721 inhibited...
Long noncoding RNA (lncRNA) has been implicated in cancer, but little is known about the role of lncRNAs as regulators tumor metastasis. In present study, we demonstrate that lncRNA TRERNA1 acts like an enhancer SNAI1 to promote cell invasion and migration contribute metastasis gastric cancer (GC). significantly unregulated GCs GC lines. Increased positively correlated with lymph node GCs. immunoprecipitation (RIP) chromatin (ChIP) assays revealed functions a scaffold recruit EZH2...