A5020486586- Viral Infections and Immunology Research
- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- Viral gastroenteritis research and epidemiology
- RNA and protein synthesis mechanisms
- Black Holes and Theoretical Physics
- Streptococcal Infections and Treatments
- High-Energy Particle Collisions Research
- Cold Atom Physics and Bose-Einstein Condensates
- Virus-based gene therapy research
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Noncommutative and Quantum Gravity Theories
- Atomic and Molecular Physics
- Cosmology and Gravitation Theories
- Genetics and Neurodevelopmental Disorders
- Infective Endocarditis Diagnosis and Management
- Plant-derived Lignans Synthesis and Bioactivity
- Ginger and Zingiberaceae research
- Genomics and Rare Diseases
- Infections and bacterial resistance
- Clostridium difficile and Clostridium perfringens research
- Advanced Chemical Physics Studies
- Dental Erosion and Treatment
- Metabolism and Genetic Disorders
Children's Hospital of Zhejiang University
2023-2025
University of Chinese Academy of Sciences
2018-2025
Inner Mongolia University
2024-2025
Beijing Computational Science Research Center
2024-2025
Chinese Academy of Sciences
2013-2024
Shanghai Public Health Clinical Center
2020-2024
Shaanxi University of Science and Technology
2024
Institute of Theoretical Physics
2022-2024
Shanghai University
2024
Henan Agricultural University
2020-2022
OBJECTIVES: Elucidating the minimal hepatic encephalopathy (MHE)-associated gut microbiome may help in predicting and lowering high risk for MHE patients with cirrhosis. METHODS: Twenty-six were recruited screened from among those liver cirrhosis without overt as defined by abnormality seen on two test modalities: number connection part A digit symbol test. Using 26 MHE-matched normal relatives 25 cirrhotic controls, means of 16S ribosomal RNA (rRNA)-based pyrosequencing, we examined...
This study aimed to create a new recombinant virus by modifying the EV-A71 capsid protein, serving as useful tool and model for studying human Enteroviruses. We developed screening method using pseudovirus particles systematically identify suitable insertion sites tag types in VP1 protein. The pseudovirus's infectivity replication can be assessed measuring postinfection luciferase signals. reported that site after 100th amino acid within BC loop of is particularly permissive various tags....
Inflammation is a critical component in the progression of various ocular diseases, such as age-related macular degeneration, diabetic retinopathy, and uveitis, leading to significant vision loss. Colchicine has been used for treating gout with its anti-inflammatory effect. However, free colchicine demonstrated cytotoxicity cells cannot directly be eye disease. Thus, this study introduces, first time, development use colchicine-encapsulated liposomes novel therapeutic approach managing...
As a sequel to our preceding work [Y. Jia et al. J. High Energy Phys. 11 (2017) 151], we carry out comprehensive comparative study between the quasiparton distribution functions (PDFs), amplitudes (DAs), and their light-cone counterparts for various flavor-neutral mesons in context of 't Hooft model, that is, two-dimensional QCD large-$N$ limit. In contrast original derivation via diagrammatic techniques exemplified by Dyson-Schwinger Bethe-Salpeter equations, here employ Hamiltonian...
Coxsackievirus A16 (CA16) belongs to the Human Enterovirus A species, which is a common pathogen causing hand, foot, and mouth disease in children. Currently, specific vaccines drugs against CA16 are unavailable, there an unmet need further understand virus invent effective treatment. Constructing infectious clone with reporter gene will greatly facilitate its virological studies. Here, we first reported construction of (rCA16) whose progeny highly replicative virulent suckling mice. On...
To investigate the presence and location of erm(T) in clinical Streptococcus suis isolates explore transmission ability fitness cost erm(T)-carrying mobile genetic elements among S. isolates, MICs were determined by broth microdilution. The was detected PCR. environment explored whole-genome sequencing (WGS) analysis. Intraspecies interspecies examined electrotransformation. associated with carriage an erm(T)-harboring plasmid or integrative conjugative element (ICE) competition experiments....
The utilization of enteroviruses engineered with reporter genes serves as a valuable tool for advancing our understanding enterovirus biology and its applications, enabling the development effective therapeutic preventive strategies. In this study, initial attempts to introduce NanoLuc luciferase (NLuc) gene into recombinant were unsuccessful in rescuing viable progenies. We hypothesized that size inserted tag might be determining factor rescue virus. Therefore, we 11-amino-acid HiBiT...
The aim of this study was to gain insight into the resistance determinants conferring tigecycline in
A bstract Evanescent operators are a special class of that vanish in four-dimensional spacetime but non-zero d = 4−2 ϵ dimensions. In this paper, we continue our systematic study the evanescent pure Yang-Mills theory and focus on their two-loop renormalization. We develop an efficient strategy to compute divergences form factors high-dimensional high-length by combining -dimensional unitarity method improved tensor reduction techniques. Two-loop anomalous dimensions obtained for dimension-10...
We present a comprehensive study of the light-cone generalized parton distribution (GPD) and quasi-GPD flavor-neutral meson in ’t Hooft model, i.e., two-dimensional QCD (<a:math xmlns:a="http://www.w3.org/1998/Math/MathML" display="inline"><a:msub><a:mi>QCD</a:mi><a:mn>2</a:mn></a:msub></a:math>) <c:math xmlns:c="http://www.w3.org/1998/Math/MathML" display="inline"><c:msub><c:mi>N</c:mi><c:mi>c</c:mi></c:msub><c:mo stretchy="false">→</c:mo><c:mi>∞</c:mi></c:math> limit. With aid Hamiltonian...
Enterovirus A89 (EV-A89) is an unconventional strain belonging to the A species. Limited research has been conducted on EV-A89, leaving its biological and pathogenic properties unclear. Developing reverse genetic tools for EV-A89 would help unravel infection mechanisms aid in development of vaccines anti-viral drugs. In this study, infectious clone was successfully constructed recombinant enterovirus (rEV-A89) generated. The rEV-A89 exhibited similar characteristics such as growth curve,...
A bstract Evanescent operators are a special class of that vanish classically in four-dimensional spacetime, while general dimensions they non-zero and expected to have non-trivial physical effects at the quantum loop level dimensional regularization. In this paper we initiate study evanescent pure Yang-Mills theory. We develop systematic method for classifying constructing d -dimensional Lorentz invariant operators, which start appear mass dimension ten. also compute one-loop form factors...
The aim of this study was to determine the mobile genetic elements involved in horizontal transfer erm (T) Enterococcus faecalis , and its transmission ability heterologous hosts. A total 159 erythromycin-resistant enterococci isolates were screened for presence macrolide resistance genes by PCR. Whole genome sequencing (T)-carrying E. E165 performed. hosts explored conjugation, transformation, fitness cost. gene detected only an isolate (1/159), which located on a 4,244-bp small plasmid,...
The species Enterovirus A (EV-A) consists of two conventional clusters and one unconventional cluster. At present, sequence analysis shows no evidence recombination between EV-A types. However, the factors underlying this genetic barrier are unclear. Here, we systematically dissected genome components linked to these peculiar phenomena, using viral reverse tools. We reported that capsids types expressed poorly in human cells. trans-encapsidation outputs across were also with low efficiency....
Objective To assess the epidemiologic attributes and microbial variations associated with extrinsic black tooth stain (BTS) among Chinese preschool children. Methods This cross-sectional study included 250 children (3–4 years) from three kindergartens in Shanghai, China. Following clinical examination, using a case-control design, saliva dental plaque specimens were collected caries-free participants ( n = 21, BTS group) without 48, control BTS. The chi-square test logistic regression model...
This work is driven by our curiosity towards some basic questions in QCD: how the energy of a moving hadron partitioned among different gauge-invariant sectors QCD Hamiltonian? How an massless pion separated between quark and gluon sectors, particularly soft limit? Is it possible to decompose celebrated Gell-Mann-Oakes-Renner (GOR) relation? To what extent can we justify potential model from field-theoretical mass decomposition for heavy quarkonium? Due limitation contemporary...
We present a comprehensive study of the light-cone generalized parton distribution (GPD) and quasi-GPD flavor-neutral meson in 't Hooft model, {\it i.e.}, two-dimensional QCD (\QCDtw) $N_c\to\infty$ limit. With aid Hamiltonian approach, we construct GPD terms meson's wave function framework light-front quantization, express Bars-Green functions chiral angle equal-time quantization. show that, both analytically numerically, does approach when is boosted to infinite momentum frame, which...
A bstract In this paper, we build on our previous work to further investigate the role of evanescent operators in gauge theories, with a particular focus their contribution violations unitarity. We develop an efficient method for calculating norms gauge-invariant Yang-Mills (YM) theory by employing on-shell form factors. Our analysis, applicable general spacetime dimensions, reveals existence negative-norm states among operators. also explore one-loop anomalous dimensions these and find...