A5080579421- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Nanoplatforms for cancer theranostics
- Gut microbiota and health
- Neuropeptides and Animal Physiology
- Nicotinic Acetylcholine Receptors Study
- Viral gastroenteritis research and epidemiology
- Lung Cancer Research Studies
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- RNA and protein synthesis mechanisms
- Natural Language Processing Techniques
- Advanced Proteomics Techniques and Applications
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Probiotics and Fermented Foods
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Speech and dialogue systems
- Inhalation and Respiratory Drug Delivery
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Biomedical Text Mining and Ontologies
Georgia Institute of Technology
2025
Fudan University
2024
Peking University
2024
Suzhou Traditional Chinese Medicine Hospital
2022-2024
Soochow University
2022-2024
Nanjing University of Chinese Medicine
2022-2024
Shaoxing People's Hospital
2024
Hangzhou Normal University
2023
The Fifth People’s Hospital of Suzhou
2022
Structural variants of the synthetic opioid fentanyl are a major threat to public health. Following an investigation showing that many derivatives poorly detected by commercial lateral flow and related assays, we created hapten conjugate vaccines using immunogenic virus-like particle carrier eight designed mimic structural features several more dangerous analogues. Immunization mice elicited strong antihapten humoral responses, allowing screening hundreds hapten-specific hybridomas for...
The remarkable success of the autoregressive paradigm has made significant advancement in Multimodal Large Language Models (MLLMs), with powerful models like Show-o, Transfusion and Emu3 achieving notable progress unified image understanding generation. For first time, we uncover a common phenomenon: capabilities MLLMs are typically stronger than their generative capabilities, gap between two. Building on this insight, propose HermesFlow, simple yet general framework designed to seamlessly...
Probiotics play essential roles in immune modulation. Combining probiotics with cancer vaccines potentially can achieve a synergistic effect. To maximize the efficacy of probiotics, proper formulation is necessary. Herein, Lactobacillus rhamnosus and Bifidobacterium longum are coated lipid membrane to goal losing less activity bettering colonization colon. In subcutaneous transplanted colon mouse model, showed potent preventive therapeutic efficacy, could be further improved by combining...
The utilization of enteroviruses engineered with reporter genes serves as a valuable tool for advancing our understanding enterovirus biology and its applications, enabling the development effective therapeutic preventive strategies. In this study, initial attempts to introduce NanoLuc luciferase (NLuc) gene into recombinant were unsuccessful in rescuing viable progenies. We hypothesized that size inserted tag might be determining factor rescue virus. Therefore, we 11-amino-acid HiBiT...
Metastatic cancers and recurrent are diverse, different from primary cancers, organ-dependent. However, how strong across-cancer immune responses among types of remain unclear. Herein, vaccines-encapsulated-whole-components-of-tumor-tissue (VEWCOTT) were applied to demonstrate the responses, thanks inducing pan-clones T-cell responses. Either lung-cancer-tissue- or melanoma-tissue-based VEWCOTT simultaneously prevented melanoma, lung cancer, hepatoma, metastatic which showed that induced....
The spread of cancer cells from the primary tumor to distant anatomical sites, known as metastasis, poses a significant challenge in clinical prognosis, impairing treatment efficacy and reducing patient survival time. Current methods for predicting diagnosing metastasis rely heavily on extensive examinations subjective judgments. Accurate rapid prediction likelihood remains an unresolved challenge, crucial guiding effective interventions extending survival. Additionally, identifying key...
Abstract In future, mRNA drugs likely play crucial roles in vaccines and protein replacement therapy etc. Lipid nanoparticles (LNPs) are the only formulation approved for delivery. However, cancer vaccine, encapsulated LNP can encode limited (20–40) tumor antigens. Due to highly heterogeneous of cells antigens, including more diverse antigens could improve efficacy vaccines. Including both strong immunogenic maximize Herein, poly (lactic‐co‐glycolic acid) (PLGA) activated dendritic cell...
Abstract: Lymphoma is the eighth most common type of cancer worldwide. Currently, lymphoma mainly classified into two main groups: Hodgkin's (HL) and non-Hodgkin's (NHL), with NHL accounting for 80% to 90% cases. primarily divided B, T, natural killer (NK) cell lymphoma. Nanotechnology developing rapidly has made significant contributions field medicine. This review summarizes advancements nanobiotechnology in recent years its applications treatment NHL, especially diffuse large B (DLBCL),...