A5073012980- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Photodynamic Therapy Research Studies
- Peptidase Inhibition and Analysis
- Single-cell and spatial transcriptomics
- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- Cell Adhesion Molecules Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Tumors and Oncological Cases
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Liver physiology and pathology
- Neuroendocrine Tumor Research Advances
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
Hunan Provincial People's Hospital
2022-2024
Hunan Normal University
2022-2024
Abstract Background The actin filament-associated protein (AFAP) family genes include AFAP1/AFAP-110, AFAP1L1 and AFAP1L2/XB130. Increasing evidence indicates these three AFAP members participate in tumor progression, but their clinical significance molecular mechanisms gastric cancer (GC) remain unclear. Methods We first analyzed expression of using public datasets verified the results. GC patients was also analyzed. In vitro vivo experiments were applied to explore function AFAP1L1....
Rationale: Pancreatic cancer, comprising mostly pancreatic ductal adenocarcinoma (PDAC), is a highly malignant disease, typically known as hypoxic tumor microenvironment. The application of PDT in cancer clinic still hampered by several shortcomings, including the (i) deep location (ii) tissue damage induced optical fibers, (iii) microenvironment, (iv) short excitation wavelengths traditional photosensitizers, and (v) poor delivery efficiency photosensitizers. Methods: We designed an organic...
Abstract To investigate the effect of long noncoding RNA (LINC01419)/miR‐485‐5p/LSM4 on malignant behavior hepatocellular carcinoma (HCC) cells. The expressions LINC01419, miR‐485‐5p, and LSM4 were determined in HCC at cellular clinical levels, cell biological was evaluated. relationships between predicted verified. Additionally, subcellular localization LINC01419 cells analyzed. Finally, an animal experiment conducted to confirm silencing tumor growth. tissues cells, increasingly expressed,...
Abstract Background Hepatocellular carcinoma (HCC) is the fifth most frequently diagnosed malignancy and third leading cause of cancer death globally. T cells are significantly correlated with progression, therapy prognosis cancer. Limited systematic studies regarding role T-cell-related markers in HCC have been performed. Methods T-cell were identified single-cell RNA sequencing (scRNA-seq) data from GEO database. A prognostic signature was developed LASSO algorithm TCGA cohort verified...
e16131 Background: Given its clear efficacy and high safety demonstrated in the phase 3 ZGDH3 study, donafenib has been recommended by Chinese guidelines for first-line treatment of unresectable hepatocellular carcinoma (uHCC). Recently, combination therapies have shown favorable results. However, clinical experience combined with anti-PD-1 therapy uHCC not yet investigated. Thus, we aimed to investigate antibody uHCC. Methods: A single-center, retrospective study was performed based on...
Pancreatic cancer involving the pancreas neck and body often invades retroperitoneal vessels, making its radical resection challenging. Multimodal treatment strategies, including neoadjuvant therapy, surgery, postoperative adjuvant are contributing to a paradigm shift in of pancreatic cancer. This strategy is also promising neck-body To evaluate feasibility effectiveness multimodal for borderline/locally advanced From January 2019 December 2021, we reviewed demographic characteristics, data,...