A5100353079- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immunotherapy and Immune Responses
- Colorectal Cancer Screening and Detection
- Drug Transport and Resistance Mechanisms
- Renal cell carcinoma treatment
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Immune cells in cancer
- Virus-based gene therapy research
- Gallbladder and Bile Duct Disorders
- Infant Health and Development
- Infrared Target Detection Methodologies
- Ferroptosis and cancer prognosis
- Facial Nerve Paralysis Treatment and Research
- Clusterin in disease pathology
- Neuroendocrine Tumor Research Advances
- Single-cell and spatial transcriptomics
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Microfluidic and Bio-sensing Technologies
China Agricultural University
2025
Xuzhou Medical College
2022-2024
Zhejiang University
2022-2024
Sichuan University
2024
West China Hospital of Sichuan University
2024
Third Affiliated Hospital of Harbin Medical University
2023-2024
Harbin Medical University
2023-2024
Capital University
2023
Capital Medical University
2023
Insilico Medicine (United States)
2023
Abstract The efficacy of checkpoint immunotherapy to non-small cell lung cancer (NSCLC) largely depends on the tumor microenvironment (TME). Here, we demonstrate that CCL7 facilitates anti-PD-1 therapy for Kras LSL−G12D/+ Tp53 fl/fl (KP) and Lkb1 (KL) NSCLC mouse models by recruiting conventional DC 1 (cDC1) into TME promote T expansion. exhibits high expression in tissues is positively correlated with infiltration cDC1 overall survival patients. deficiency impairs subsequent expansion CD8 +...
Background Pancreatic cancer remains an extremely malignant digestive tract tumor, posing a significant global public health burden. Patients with pancreatic cancer, once metastasis occurs, lose all hope of cure, and prognosis is poor. It important to investigate liver in depth, not just because it the most common form but also crucial for treatment planning assessment. This study aims delve into mechanisms metastasis, goal providing scientific groundwork development future methods drugs....
In order to investigate the impact of Treg cell infiltration on immune response against pancreatic cancer within tumor microenvironment (TME), and identify crucial mRNA markers associated with cells in cancer, our study aims delve into role anti-tumor cancer.The ordinary transcriptome data for this was sourced from GEO TCGA databases. It analyzed using single-cell sequencing analysis machine learning. To assess level tissues, we employed CIBERSORT method. The identification genes most...
Abstract Background Textbook oncologic outcomes (TOO) have been used to evaluate long-term for patients after pancreaticoduodenectomy (PD) but not laparoscopic (LPD). The aim of the study was assess prognostic value TOO with pancreatic head cancer undergoing LPD and discuss risk factors associated achieving TOO. Methods Patients who underwent in West China Hospital from January 2015 May 2022 were consecutively enrolled. defined as R0 resection, examination ≥ 12 lymph nodes, no prolonged...
To investigate the pharmacological effect of JCM-16021, a Chinese herbal formula, and its underlying mechanisms.JCM-16021 is composed seven plant materials. All raw materials formula were examined according to quality control criteria listed in Pharmacopeia (2005). In neonatal maternal separation (NMS) model, male Sprague-Dawley rats submitted daily from postnatal day 2 14, or no specific handling (NH). Starting 60, administered JCM-16021 (2, 4, 8 g/kg per day) orally twice for 28 d. Pain...
Long noncoding RNA taurine upregulated gene 1 (lncRNA TUG1) and microRNA‑196a (miR‑196a) have been reported to serve important roles in the development of renal cell carcinoma (RCC). However, their potential mechanisms not completely elucidated. The aim present study was clarify biological functions lncRNA‑TUG1 miR‑196a, addition investigating interaction between microRNA‑196a, providing a novel insight into RCC tumorigenesis. comprised two parts. In first part, confirmed as an oncogene, via...
The potent cytotoxic property of Vγ2Vδ2 T cells makes them attractive for adoptive cell transfer therapy. transfusing the expanded into cancer patients shows well-tolerated, but clinical response rates are required to be improved, implying that there is still an unmet efficacy with low toxicity this novel anti-tumor In study, we test a Y-body-based bispecific antibody (bsAb) Vγ2 x PD-L1 preferentially redirects combat positive tumor cells. With nanomolar affinity levels and PD-L1+ cells,...
Achieving textbook outcome (TO) implies a smooth recovery post-operation without specified composite complications. This study aimed to evaluate TO in laparoscopic pancreaticoduodenectomy (LPD) and identify independent risk factors associated with achieving TO. We conducted retrospective analysis of data from randomized controlled trial on LPD at West China Hospital (ChiCTR1900026653). Patients were categorized into the non-TO groups. Perioperative variables compared between these...
Chimeric antigen receptor (CAR) T cell therapy is an advanced and effective immunotherapy for relapsed or refractory B-cell malignancies. High expansion of CAR cells in vivo durable antitumor activity indicate a persistent therapeutic response. However, this treatment linked to high frequency adverse events, such as cytokine release syndrome (CRS), which affects its efficacy can even be life-threatening. At present, variety markers associated with clinical response toxicity after infusion...
Papillary renal cell carcinoma (PRCC) is one of the most common histological subtypes carcinoma. Type 1 and type 2 PRCC are reported to be clinically biologically distinct. However, little known about immune infiltration expression patterns immune-related genes in these two histologic subtypes, thereby limiting development immunotherapy for PRCC. Thus, we analyzed 22 cells tissues by combining The Cancer Genome Atlas (TCGA) database with ESTIMATE CIBERSORT algorithms. Subsequently, extracted...
Epstein-Barr virus (EBV) persistently infects T/natural killer (NK) cells causing an array of refractory EBV-associated T/NK-cell lymphoproliferative disorders. EBV-encoded microRNAs are important regulators for EBV latent infection and tumorigenesis. However, the roles most in EBV-infected T/NK remain poorly understood. On basis a search doRiNA database BiBiServ2-RNAhybrid website, we predicted that EBV-miR-BART17-3p targeted DDX3X, verified hypothesis by dual-luciferase reporter assay cell...
Introduction: In recent years, evidence has accumulated to suggest that patients with bipolar disorder show altered processing of emotionally relevant information. However, only a few studies have examined manic patients' eye movements when facial expressions. Method: A free viewing task and anti-saccade were used separately investigate attentional bias response inhibition while emotional stimuli. Data drawn from matched samples (n = 25) healthy controls 20). Results: The analyses...
Previous studies had already reported the efficacy of electroacupuncture treatment for idiopathic facial nerve palsy (IFP) in a recovery phase; however, initial use acute phase remains controversial. Hence, present study, we will add intervention based on oral prednisone tablets IFP and compare clinical effects with simple tablets. Besides, prognosis safety be evaluated. The study aims to evaluate efficacy, prognosis, combined IFP, using surface electromyography (sEMG) objectively observe...
Salt-inducible kinase 2 (SIK2) has been recognized as a potential target for anti-inflammation and anti-cancer therapy. In this paper, based on the binding pose of reported compound (GLPG-3970, 3) with AlphaFold protein structure, series hinge cores were generated via AI-generative models (Chemistry42). After molecular docking, synthesis, biological evaluation, hit molecule (7f) targeting SIK2 was obtained novel scaffold. Further SAR exploration led to discovery 8g superior potency against...
<title>Abstract</title> Objective Achieving textbook outcome (TO) means smooth recovery after operation without specified composite complications. This study aimed to assess TO in laparoscopic pancreaticoduodenectomy (LPD) and find independent risk factors for achieving it. Methods We performed a retrospective data analysis from randomized controlled trial LPD conducted at West China Hospital (ChiCTR1900026653). Patients were classified into the non-TO groups. Perioperative variables...
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