A5069416144- Hepatocellular Carcinoma Treatment and Prognosis
- Congenital Heart Disease Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cardiac Structural Anomalies and Repair
- Acute Ischemic Stroke Management
- Liver physiology and pathology
- Hedgehog Signaling Pathway Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Ferroptosis and cancer prognosis
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Drug Transport and Resistance Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- FOXO transcription factor regulation
- Immune cells in cancer
- Coronary Artery Anomalies
- Cancer Cells and Metastasis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Inflammatory Biomarkers in Disease Prognosis
- Cell Adhesion Molecules Research
Shanghai Tenth People's Hospital
2023-2025
Tongji University
2023-2025
Second Affiliated Hospital of Guangzhou Medical University
2025
Guangzhou Medical University
2025
Huashan Hospital
2019-2020
Fudan University
2019-2020
Air Force Medical University
2010
Xijing Hospital
2006
Tertiary lymphoid structures (TLSs) have been proposed to assess the prognosis of patients with cancer. Here, we investigated prognostic value and relevant mechanisms TLSs in colorectal cancer liver metastases (CRCLM).603 CRCLM treated by surgical resection from three centers were included. The categorized according their anatomic subregions quantified, a TLS scoring system was established for intratumor region (T score) peritumor (P score). Differences relapse-free survival (RFS) overall...
Host and tumorous inflammation actively affect liver metastasis of colorectal cancer (CRC). Neutrophils have been recognized as one active participant in procedure, with controversial roles however. Activated neutrophils release extracellular traps (NETs) which are involved infection multiple pathological conditions. NETs on is getting but less elucidated mechanism. How interact cells still largely unknown. In this study, we found that from CRC patients, especially those metastatic,...
Abstract STMN1 has been regarded as an oncogene and its upregulation is closely associated with malignant behavior poor prognosis in multiple cancers. However, the detailed functions underlying mechanisms of are still largely unknown hepatocellular carcinoma (HCC) development. Herein, we analyzed expression related clinical significance HCC by using well‐established Protein Atlas, The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) cancer databases. Analysis indicated that was...
AimsThe aim of this study was to evaluate the safety and efficacy transcatheter closure for perimembranous ventricular septal defect (pmVSD) its long-term results. The most common congenital heart condition is pmVSD. Transcatheter pmVSD a recently described technique with limited results mid- follow-up.
Abstract Multidrug resistance is one of the reasons for low survival advanced hepatocellular carcinoma (HCC). Our previous studies indicate that hedgehog signalling involved in hepatic carcinogenesis, metastasis and chemo‐resistance. The present study aims to uncover molecular mechanisms underlying hepatoma TAP1 GLI1/2 gene expression was assessed both poorly differentiated cells HCC specimens. Potential GLI‐binding site promoter sequence validated by assays. Approximately 75% specimens...
Neutrophil-to-lymphocyte ratio (NLR) is a promising prognostic marker for patients undergoing hepatectomy colorectal liver metastases (CRLM). However, its value in receiving neoadjuvant therapy (NAT) has not been sufficiently addressed. From 2013 to 2023, cohort of 692 with CRLM were enrolled five centers. Clinicopathological characteristics obtained from prospectively maintained multi-center database. The effect NLR (> 2 versus ≤ 2) on overall survival (OS) and recurrence-free was estimated...
<title>Abstract</title> Background Clopidogrel plays an important role in the treatment of acute ischemic strokes (AIS) through antiplatelet activity. However, some patients have clopidogrel resistance (CR), which could lead to stroke recurrence and bleeding. This study aimed explore associated factors CR establish a diagnostic nomogram for predicting probability AIS patients. Methods retrospective involved 692 from Second Affiliated Hospital Guangzhou Medical University, treated with (75...
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