A5087155831- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Advanced Neuroimaging Techniques and Applications
- Neurosurgical Procedures and Complications
- Retinal and Optic Conditions
- Advanced MRI Techniques and Applications
- Advanced Technologies in Various Fields
- MRI in cancer diagnosis
- Cerebral Venous Sinus Thrombosis
- Trauma and Emergency Care Studies
- Folate and B Vitamins Research
- Advanced Computing and Algorithms
- Vascular anomalies and interventions
- Congenital Heart Disease Studies
- Bone and Joint Diseases
- Medical Imaging and Analysis
- Renal and Vascular Pathologies
Lishui University
2019-2025
Lishui City People's Hospital
2021-2025
Wenzhou Medical University
2022-2024
Second Affiliated Hospital of Zhejiang University
2015-2018
Shanghai Jiao Tong University
2009
Renji Hospital
2009
Current evidence provides limited support for the superiority of endovascular thrombectomy (EVT) in patients with M2 segment middle cerebral artery occlusion. We aim to investigate whether imaging features occlusion impact effectiveness EVT.
<title>Abstract</title> Background Clopidogrel plays an important role in the treatment of acute ischemic strokes (AIS) through antiplatelet activity. However, some patients have clopidogrel resistance (CR), which could lead to stroke recurrence and bleeding. This study aimed explore associated factors CR establish a diagnostic nomogram for predicting probability AIS patients. Methods retrospective involved 692 from Second Affiliated Hospital Guangzhou Medical University, treated with (75...
Cerebral venous collagenosis played a role in the pathogenesis of white matter hyperintensities (WMHs) through ischemia. Since pathological changes veins from intramural stenosis to luminal occlusion is dynamic process, we aimed create deep medullary (DMVs) visual grade on susceptibility-weighted images (SWI) and explore relationship DMVs WMHs based drainage regions. We reviewed clinical, laboratory imaging data 268 consecutive patients 20 controls. SWI were used observe characteristics...
Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) can improve clinical outcome in eligible patients acute ischemic stroke (AIS). However, its efficacy is strongly time-dependent. This study was aimed to examine whether prehospital notification by emergency medical service (EMS) providers could reduce onset needle time (ONT) and neurological AIS who received IVT. We prospectively collected the consecutive data of IVT during one year after initiation...
Previous studies have suggested that cerebral dural sinus stenosis could be a possible underlying cause of idiopathic intracranial hypertension (IIH). Venous stenting (VSS) has emerged as potential alternative for treating IIH related to stenosis. However, most the documented been conducted in Western countries. In this study, we present results 16 Chinese patients who underwent VSS treatment our single center.
Leukoaraiosis is associated with increased risk of cognitive impairment, but its pathophysiological pathway unclear. The aim the present study was to determine whether brain structural damage or cerebral blood supply better correlated global outcome in subjects leukoaraiosis. Seventy-five leukoaraiosis were included study, age ranged from 43 85 years, mean white matter hyperintensities (WMH) volume 30.69 ± 24.35 mL. Among them, 19(25.33%) presented microbleeds (CMB) and 40 (53.33%) lacunes....
Remote intracerebral hemorrhage (rICH) is infrequent after intravenous thrombolysis (IVT) and its mechanism remains poorly understood. We aimed to assess frequency possible relationship with the severity of white matter hyperintensity (WMH) in patients acute ischemic stroke.We prospectively analyzed data from consecutive stroke magnetic resonance imaging IVT. WMH volume was quantitatively measured. rICH defined as intracranial that appears brain regions without visible changes on 24-h...
We aimed to investigate the effectiveness of endovascular therapy (EVT) versus intravenous thrombolysis (IVT) in patients with basilar artery occlusion (BAO), based on information advanced imaging.We analyzed data stroke radiologically confirmed BAO within 24 hours. subjects were categorized into "top-of-the-basilar" syndrome (TOBS) and other types. An initial infarct size <70ml a ratio ischemic tissue volume ≥1.8 was defined as "target mismatch." The primary outcome good outcome, modified...
To evaluate the safety of intravenous thrombolysis (IVT) in cerebral microbleeds (CMBs) patients with prior antiplatelet therapy.Four hundred and forty nine acute ischemic stroke aged (66.8 ± 12.9) years, including 298 males 151 females, underwent susceptibility-weighted imaging (SWI) examination MRI-guided IVT therapy between June 2009 2015. The presence CMBs, previous therapy, HT subtypes according to ECASS II criteria functional outcome based on modified Rankin scale (mRS) at 3 months...
To investigate the association of serum folate level with severity white matter hyperintensity (WMH) and presence cerebral microbleeds (CMB).Clinical data WMH patients from second affiliated Hospital, Zhejiang University school Medicine during July 2011 February 2016 were retrospectively reviewed. According to Fazekas score based on T2-Flair images, classified into mild (0-3) severe (4-6). The CMB was assessed susceptibility weighted imaging (SWI). Binary logistic analysis conducted identify...
To investigate factors related to hemorrhagic transformation and favorable outcomes in wake-up ischemic stroke (WUIS) patients undergoing intravenous thrombolytic therapy.Clinical data of 600 multimodal image-guided recombinant tissue plasminogen activator (rt-PA) therapy Department Neurology, the Second Affiliated Hospital, Zhejiang University School Medicine center from May 2009 2015 were retrospectively analyzed. Among patients, 68 diagnosed as WUIS including 17 cases aged 80 or older....
Objective To investigate the prevalence of chronic kidney disease （CKD） in patients with acute stroke and risk factors prognostic characteristics these patients. Methods A total 270 consecutive hospitalized was recruited, their CKD evaluated transversally. Various short-term prognosis 53 whose National Institutes Health Stroke Scale （NIHSS） scores were similar at admission among compared to those 106 without CKD. defined as glomertdar filtration rate （GFR） 〈 60 ml/（min · 1.73 m^2） （or）...
To investigate the effect of tirofiban on hemorrhagic transformation and neurological outcome in patients with acute cerebral infarct treated endovascular therapy.One hundred fifteen who received stent mechanical thrombectomy Second Affiliated Hospital, Zhejiang University School Medicine during October 2013 April 2017 were included study. Among 115 patients, 30 treatment. Hemorrhagic outcomes assessed using ECASS Ⅱ criteria modified Rankin scale (mRS), respectively. Unfavorable was defined...
To evaluate the collateral flow in patients with ischemic stroke due to acute basilar artery occlusion by dynamic CT angiography and predict outcome after reperfusion therapy.Forty-five undergoing treatment Second Affiliated Hospital of Zhejiang University School Medicine during January 2012 August 2016 were retrospectively reviewed. Univariate binary logistic regression model used identify independent predictors patient's outcome, receiver operating characteristic (ROC) curve was determine...
Objective To investigate the reversibility of ischemic core defined by CT perfusion imaging in acute stroke (AIS) patients receiving intravenous thrombolysis within different time windows and influencing factors. Methods The data AIS who received Department Neurology Lishui People′s Hospital from May 2016 to December 2018 were retrospectively reviewed. All had finished multi-model before MRI examination 24-48 hours after thrombolysis. The baseline volume (hypoperfusion area with...