A5101402669- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Cancer Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Gout, Hyperuricemia, Uric Acid
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiopharmaceutical Chemistry and Applications
- Bone health and treatments
- Pancreatic and Hepatic Oncology Research
- Medical Imaging and Pathology Studies
- Advanced X-ray and CT Imaging
- RNA modifications and cancer
- Renal cell carcinoma treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Natural Compound Pharmacology Studies
- Thyroid and Parathyroid Surgery
- Lung Cancer Diagnosis and Treatment
- Retinal and Macular Surgery
- Cell death mechanisms and regulation
- Cholesterol and Lipid Metabolism
- Molecular Biology Techniques and Applications
- Polysaccharides and Plant Cell Walls
Nanyang Technological University
2025
Jilin University
2023-2024
Xiamen Chang Gung Hospital
2023-2024
Xiamen Medical College
2023-2024
South China Agricultural University
2024
Chinese Academy of Sciences
2024
Zhejiang University of Technology
2023-2024
Zhejiang University
2024
Peking University First Hospital
2024
Peking University
2024
Abstract Hyperuricemia (HUA) is a metabolic syndrome caused by abnormal purine metabolism. Although recent studies have noted relationship between the gut microbiota and gout, whether could ameliorate HUA-associated systemic metabolism remains unclear. In this study, we constructed novel model of HUA in geese investigated mechanism which Lactobacillus rhamnosus GG (LGG) beneficial effects on HUA. The administration antibiotics fecal transplantation (FMT) experiments were used goose model....
BACKGROUND Helicobacter pylori (HP), the most common pathogenic microorganism in stomach, can induce inflammatory reactions gastric mucosa, causing chronic gastritis and even cancer. HP infection affects over 4.4 billion people globally, with a worldwide rate of up to 50%. The multidrug resistance poses serious challenge eradication. It has been de-monstrated that compared bismuth quadruple therapy, Qingre Huashi decoction (QHD) combined triple therapy exhibits comparable eradication rates...
Abstract Background Breast cancer (BC) is the second leading cause of cancer‐related deaths among women, primarily due to metastases other organs rather than primary tumor. Methods In this study, a comprehensive analysis plasma proteomics and metabolomics was conducted on cohort 51 BC patients. Potential biomarkers were screened by Least Absolute Shrinkage Selection Operator (LASSO) regression Random Forest algorithm. Additionally, enzyme‐linked immunosorbent assay (ELISA) kits untargeted...
The gut microbiota is implicated in the pathogenesis of hyperuricemia (HUA) and gout. However, it remains unclear whether probiotics residing host gut, such as Lactobacillus, can prevent HUA development. Herein, we isolated Lactobacillus plantarum SQ001 from cecum geese conducted vitro assays on uric acid (UA) nucleoside co-culture. Metabolomics genome-wide analyses, revealed that this strain may promote uptake hydrolysis through its hydrolase gene. functional role iunH gene was confirmed...
To compare the detection rate of 64-slice CT, digital subtraction angiography (DSA) and C-arm computed tomography (C-arm CT) in small lesions with a diameter ≤3.0 cm hepatocellular carcinoma (HCC).Sixty-six patients HCC underwent DSA, were followed up by lipiodol CT two weeks after transcatheter arterial chemoembolization (TACE). Whose result was used as diagnostic reference. The number detected each imaging modality counted independently 4 radiologists.A total 174 out 66 confirmed among...
Background Most head and neck squamous cell carcinoma (HNSCC) patients are diagnosed at an advanced local stage. While immunotherapy has improved survival rates, only a minority of respond durably to targeted immunotherapies, posing substantial clinical challenges. We investigated the heterogeneity tumor microenvironment in HNSCC cohorts before after by analyzing single-cell RNA sequencing (scRNA-seq) data bulk datasets retrieved from public databases. Methods constructed transcriptome...
To investigate the effects of microwave ablation (MWA) on visible benign thyroid nodules (BTN) with different internal characteristics.A total 51 cases 53 BTN were treated by ultrasound-guided percutaneous MWA. The classified into three categories according to characteristics, which simple solid, mainly solid and cystic nodules. Ultrasound examinations performed evaluate volume shrinkage rations during follow-up. functions cervical cosmetic scores evaluated. complications observed after...
Efavirenz (EFV), a widely prescribed antiviral medication, has been implicated in dyslipidemia and can activate the pregnane X receptor (PXR), leading to hepatic steatosis hypercholesterolemia mice. Resveratrol (RES) ameliorate functions as partial PXR agonist, capable of mitigating expression induced by other agonists. Therefore, we hypothesized that RES could attenuate EFV-induced downregulating suppressing inflammatory cytokine production. Here, conducted an vivo study involving...
This study aimed to assess the exposure level and risk of Di-2-ethylhexyl Phthalate (DEHP) among adults in Jilin Province, China, clarify impact DEHP on human thyroid function, explore role estrogen receptors (ERs)-Notch signaling pathway effect metabolites hormones based population data vitro experiments.
Mitochondria play a crucial role in the occurrence and development of tumors. We used mitochondria-related genes for consistent clustering to identify three stable molecular subtypes head neck squamous cell carcinoma (HNSCC) with different prognoses, mutations, immune characteristics. Significant differences were observed clinical characteristics, microenvironment, infiltration, scores. TP53 was most significantly mutated; cycle-related pathways tumorigenesis-related activated subtypes. Risk...
Abstract Sepsis poses a health challenge globally owing to markedly high rates of morbidity and mortality. Despite employing bundle therapy over two decades, approaches including transient organ supportive clinical trials focusing on signaling pathways have failed in effectively reversing multiple failure patients with sepsis. Prompt appropriate perioperative management for surgical concurrent sepsis is urgent. Consequently, innovative therapies remedying injuries are necessitated. Cell has...
Abstract Gut microbiota has been considered to be associated with the development of hyperuricemia (HUA) and gout. Some prebiotics from different sources had potential alleviation function in HUA. However, whether host-derived probiotics, like Lactobacillus, gut HUA animals could prevent is still uncertain. In this study, we established a geese model isolated Lactobacillus plantarum strain, SQ001, cecum geese. Nucleoside co-culture metabolomics analyses revealed that L. SQ001 involved...
Abstract The embryonic development of the pancreas originates from dorsal and ventral anlagen, pancreatic cancer arising or may have different clinical pathology features. This study aims to explore whether there are differences in clinicopathological features prognosis head carcinoma pancreas. Between January 2014 February 2018, 101 patients with resectable who underwent pancreaticoduodenectomy our institution were retrospectively reviewed. assigned into 2 groups according tumor location on...