A5054596213- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Bone and Joint Diseases
- Orthopedic Infections and Treatments
- Surgical site infection prevention
- Bone fractures and treatments
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Cardiac tumors and thrombi
- Childhood Cancer Survivors' Quality of Life
- Autoimmune and Inflammatory Disorders Research
- Reconstructive Surgery and Microvascular Techniques
- Hip disorders and treatments
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Colorectal Cancer Treatments and Studies
- Neuroblastoma Research and Treatments
- Management of metastatic bone disease
- Vascular Tumors and Angiosarcomas
- Mesenchymal stem cell research
- Connective tissue disorders research
- Muscle Physiology and Disorders
- Cancer Treatment and Pharmacology
- CAR-T cell therapy research
- Cancer survivorship and care
St. Jude Children's Research Hospital
2016-2025
Princess Máxima Center
2023
University of Memphis
2018
Cook Children's Medical Center
2015
Johns Hopkins University
2014
University of Tennessee Health Science Center
2005-2014
Stanford Medicine
2014
The University of Texas MD Anderson Cancer Center
2014
In-Q-Tel
2008
University of Tennessee at Knoxville
2001-2007
Treatment with isolated allogeneic mesenchymal cells has the potential to enhance therapeutic effects of conventional bone marrow transplantation in patients genetic disorders affecting tissues, including bone, cartilage, and muscle. To demonstrate feasibility cell therapy gain insight into transplant biology these cells, we used gene-marked, donor marrow-derived treat six children who had undergone standard for severe osteogenesis imperfecta. Each child received two infusions cells. Five...
Key Points Cas9 editing of the γ-globin gene promoters in hematopoietic stem cells (HSCs) increases red cell HbF by ≤40%. No deleterious effects on hematopoiesis or off-target mutations were detected 16 weeks after xenotransplantation edited HSCs.
BACKGROUND Chemotherapy has improved the outcome of patients with newly diagnosed osteosarcoma, but its role in relapsed disease is unclear. METHODS We reviewed records all who were treated for high‐grade osteosarcoma at our institution between 1970 and 2004. Postrelapse event‐free survival (PREFS) postrelapse (PRS) estimated, comparisons made using an exact log‐rank test. RESULTS The 10‐year PREFS PRS 110 11.8% ± 3.5% 17.0% 4.3%, respectively. Metastasis initial diagnosis (14%), relapse...
Osteoid osteoma is a benign bone tumor. Patients usually require surgical treatment for reliable pain relief. Difficulties with intraoperative localization of the tumor and anatomic locations that carry high morbidity en bloc resection complicate open surgery. Various methods have been developed to lessen invasiveness surgery including computed tomography-guided percutaneous radiofrequency thermal ablation. Eleven patients in three different centers were evaluated diagnosed osteoid based on...
One of the adverse effects therapy for acute lymphoblastic leukemia (ALL) is osteonecrosis hip. Putative risk factors have included being female, white race, and older age. Our goal was to define possible genetic among children treated newly diagnosed ALL.Using a candidate gene approach, we determined genotypes 16 common polymorphisms in genes likely affect pharmacokinetics or pharmacodynamics antileukemic medications 64 with ALL. Therapy glucocorticoids antifolates. Magnetic resonance...
Abstract Background Comparison of functional mobility and quality life is performed in patients with lower‐extremity bone sarcoma following either amputation, limb‐sparing surgery, or rotationplasty four different types outcome measures: (1) an objective measure that requires to physically perform specific tasks, assessment (FMA); (2) a clinician administered tool, Musculoskeletal Tumor Society Scale (MSTS); (3) patient questionnaire, Toronto Extremity Salvage (TESS); (4) health‐related...
Osteonecrosis of the capital femoral epiphysis is a significant late toxicity treatment for childhood leukemia and lymphoma. We determined clinical imaging risk factors predicting joint outcomes head osteonecrosis in pediatric patients with or lymphoma.We reviewed retrospectively medical records magnetic resonance scans 80 epiphysis. Logistic regression was used to examine relationships between surface collapse arthroplasty. Kaplan-Meier survival curves display time arthroplasty based on...
Abstract BACKGROUND: The standard treatment of osteosarcoma includes cisplatin and high‐dose methotrexate (HDMTX); both agents exert significant toxicity, HDMTX requires complex pharmacokinetic monitoring leucovorin rescue. In the previous OS91 trial, localized disease with carboplatin, ifosfamide, doxorubicin, yielded outcomes comparable to those cisplatin‐based regimens caused less toxicity. To build on this experience, authors conducted a multi‐institutional trial (OS99) that evaluated...
Purpose Hip osteonecrosis frequently complicates treatment with glucocorticoids. When extensive (affecting ≥ 30% of the epiphyseal surface), 80% joints collapse within 2 years, so interventions are needed to prevent this outcome. Patients and Methods This prospective cohort magnetic resonance imaging (MRI) screening study included all consecutive children treated for acute lymphoblastic leukemia on a single protocol. MRI was performed at 6.5 9 months from diagnosis (early screening)...
A noninvasive expandable prosthesis for skeletally immature children after limb salvage surgery has been developed. Between 1998 and 2001, 18 Phenix prostheses were implanted in 15 pediatric patients who had diagnosed treated osteosarcoma about the knee. Of original prostheses, 10 at time of primary tumor resection five revisions from an endoprosthetic modular knee system. Sixty expansions done, with all but two done as outpatient procedures. An average 8.5 mm was obtained per lengthening...
Abstract BACKGROUND The outcome of patients with metastatic osteosarcoma treated in two consecutive trials from 1986 to 1997 was analyzed evaluate the efficacy carboplatin‐based multiagent chemotherapy and identify prognostic factors. initial study (OS‐86) used ifosfamide, cisplatin, doxorubicin, high‐dose methotrexate, subsequent (OS‐91) same agents at similar doses, but carboplatin substituted for cisplatin. METHODS Twelve (median age, 15.1 yrs) were OS‐86 lung only (11 patients) or bone...
PURPOSE: To determine the activity of carboplatin/ifosfamide in patients with previously untreated osteosarcoma and to estimate patient outcomes after a multiagent chemotherapy protocol that eliminated cisplatin. PATIENTS AND METHODS: Sixty-nine newly diagnosed, received three cycles carboplatin (560 mg/m 2 × 1) ifosfamide (2.65 g/m /d 3). Assessment response was evaluated two (week 6) 9) cycles. At week 9, histologic assessed. Adjuvant therapy comprised additional cycles, doxorubicin,...
Increased vascular endothelial growth factor (VEGF) expression in osteosarcoma correlates with a poor outcome. We conducted phase II trial to evaluate the feasibility and efficacy of combining bevacizumab, monoclonal antibody against VEGF, methotrexate, doxorubicin cisplatin (MAP) patients localized osteosarcoma. Eligible received two courses MAP chemotherapy before definitive surgery at week 10. Bevacizumab (15 mg/kg) was administered 3 days starting then on day 1 weeks 5 chemotherapy....
Despite success in treating childhood acute lymphoblastic leukemia and lymphoma (ALL), modern multiagent chemotherapy regimens containing high-dose corticosteroids can result osteonecrosis afflicting survivors, frequently involving the knee. Thus, we describe usage of fresh osteoarticular allograft (FOAG) to treat steroid-induced femoral condyle pediatric cancer survivors. We assessed efficacy FOAGs heal necrotic bone, provide long-term pain relief, while retrospectively reviewing quality...
Vascular injury has been reported in up to one third of patients with posterior knee dislocations, which led the routine use arteriograms management these injuries. Recent studies have shown physical examination (PE) is reliable detecting significant vascular injuries requiring surgery from other mechanisms. We hypothesized that PE would be similarly sufficient assess popliteal dislocations. To test this, we reviewed records all 37 38 such at our institution over past 5 years. The average...
The poor prognosis for patients with osteosarcoma skip metastases has been established in the literature; however, most of data literature concerning were collected before routine use magnetic resonance imaging and modern multiagent chemotherapy regimens. This retrospective multiinstitutional study was done to evaluate efficacy detect these when treated protocols. In a group 155 who younger than 26 years diagnosed high-grade long bones, 10 (6.5%) identified. Eight lesions detected on...
Abstract Background Local tumor control for patients with Ewings sarcoma family of tumors (ESFT) is favorable when the primary resectable or small. failure rates who received combined surgery and RT were reviewed to determine outcome prognostic factors. Procedures We performed a retrospective review all localized ESFT treated definitive between 1978 2001, at St. Jude Children's Research Hospital. Rates local failure, survival, factors recurrence determined in 39 therapy. Systemic treatment...
Abstract BACKGROUND The local management of Ewing sarcoma family tumors (ESFT) often centers on the surgical resectability primary lesion and physician biases regarding differences in morbidity between radiotherapeutic management. METHODS authors retrospectively reviewed records 33 patients with localized ESFT who underwent surgery received systemic chemotherapy at St. Jude Children's Research Hospital (Memphis, TN). Two multiagent regimens were used: 14 vincristine, doxorubicin,...