A5069484787- Dialysis and Renal Disease Management
- Systemic Lupus Erythematosus Research
- Renal and Vascular Pathologies
- Rheumatoid Arthritis Research and Therapies
- Chronic Kidney Disease and Diabetes
- Central Venous Catheters and Hemodialysis
- Archaeology and Natural History
- Autoimmune and Inflammatory Disorders Research
- Renal Transplantation Outcomes and Treatments
- Nutritional Studies and Diet
- Psoriasis: Treatment and Pathogenesis
- Systemic Sclerosis and Related Diseases
- Lymphoma Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Pregnancy and Medication Impact
- Renal function and acid-base balance
- Eosinophilic Disorders and Syndromes
- Sinusitis and nasal conditions
- Folate and B Vitamins Research
- Ecology and biodiversity studies
- Spondyloarthritis Studies and Treatments
- Potassium and Related Disorders
- Atherosclerosis and Cardiovascular Diseases
- Mental Health and Patient Involvement
- Biosimilars and Bioanalytical Methods
Royal Adelaide Hospital
2010-2025
The University of Adelaide
2007-2025
Australia and New Zealand Dialysis and Transplant Registry
2004-2025
South Australian Health and Medical Research Institute
2025
University of Ulster
2018-2024
Altnagelvin Area Hospital
2018-2024
NIHR Oxford Musculoskeletal Biomedical Research Centre
2023
NIHR Manchester Biomedical Research Centre
2019-2023
University of Manchester
2001-2023
Manchester Academic Health Science Centre
2019-2023
Increasing numbers of elderly patients face decisions about the management end-stage kidney disease. Improved understanding contemporary patient and practice factors influencing prognosis may assist decision making for individual their care providers. This is a prospective registry study using multivariable proportional hazards models. A total 1781 aged ≥75 years at dialysis initiation recorded in ANZDATA, Australia New Zealand renal replacement registry, between January 2002 December 2005....
Australian Aborigines living in remote areas have exceedingly high rates of renal failure together with increased cardiovascular morbidity and mortality. To examine the basis this association, we studied markers function (CV) risk a coastal Aboriginal community area Northern Territory Australia. End-stage disease (ESRD) incidence that are 15 times national non-Aboriginal rate CV mortality region 5-fold.A cross-sectional survey was conducted. Markers early examined included urine...
Aboriginal Australians are at high risk of cardiovascular, metabolic and renal diseases, resulting in a marked reduction life expectancy when compared to the rest Australian population. This is partly due recognized environmental lifestyle factors, but contribution genetic susceptibility also likely.Using results from comprehensive survey one community (N = 1350 examined individuals), we have tested for familial aggregation plasma glucose, arterial blood pressure, albuminuria (measured as...
Introduction Previous studies have shown that there is a higher incidence of men initiating kidney replacement therapy (KRT) in comparison to women. However, the contribution gender disparity may well differ among different types disease, and over time. Utilising nationwide Registry, we examined disease- gender-specific trends incident failure required KRT. Methods Registry-based analysis all patients commencing KRT Australia using data from New Zealand Dialysis Transplant (ANZDATA)...
Abstract Objective To examine the accuracy of Australia and New Zealand Dialysis Transplant Registry (ANZDATA), population‐based clinical quality registry for people with kidney failure, in identifying Aboriginal and/or Torres Strait Islander people. Design Population‐based cohort study reporting accuracy. Setting South Wales, 2006–2020. Participants Incident failure patients. Main outcome measures Sensitivity specificity identification ANZDATA compared Enhanced Reporting Aboriginality (ERA)...
Coagulase-negative staphylococcal (CNS) peritonitis is the most common cause of peritoneal dialysis (PD)-associated peritonitis. Previous reports this important condition have been sparse and generally limited to single-centre studies.The frequency, predictors, treatment clinical outcomes CNS were examined by multivariate logistic regression multilevel Poisson in all adult PD patients Australia between 2003 2006.A total 936 episodes (constituting 26% episodes) occurred 620 individuals. The...
Background. Although Indigenous Australians, New Zealand Maori and Pacific Island people comprise an unduly high proportion of patients treated for end-stage renal disease (ESRD) in the two countries, no population-based age- disease-specific rates have been published.
The International Quotidian Dialysis Registry was designed to collect data describing treatments, characteristics, and outcomes of patients treated with quotidian hemodialysis (HD) worldwide. In July 2004, North American centers were first invited enroll patients. By March 1, 2005, a total 70 nocturnal 8 short-daily HD from three Canadian two US enrolled. As recruitment continues, projected enrollment for 2005 may exceed 200 America alone. Preliminary analyses indicate that the current...
Abstract Background: Heavy kava use in Aboriginal communities has been linked to various health effects, including anecdotes of sudden cardiac deaths. Aims: To examine associations between and potential effects. Methods: A cross‐sectional study was carried out within a kava‐using east Arnhem Land community tropical northern Australia. One‐hundred‐and‐one adults who were current, recent or non‐users enrolled March 2000. Main outcome measures physical, anthropometric, biochemical,...
Objectives To identify predictors of overall lupus and nephritis (LN) responses in patients with LN. Methods Data from the Aspreva Lupus Management Study (ALMS) trial cohort was used to baseline response at 6 months. Endpoints were major clinical (MCR), improvement, complete renal (CRR) partial (PRR). Univariate multivariate logistic regressions least absolute shrinkage selection operator (LASSO) cross-validation randomly split samples utilised. Predictors ranked by percentage times selected...
Objective: To evaluate the outcomes of and barriers to implementing standard guidelines (Caring for Australasians with renal impairment [CARI]), using iron management in patients having dialysis as an example. Design setting: On-site review processes at six Australian units varying size locality. Patients’ indices haemoglobin levels were obtained from New Zealand Dialysis Transplant Registry. Participants: Patients chronic kidney disease who dependent on dialysis. Main outcome measures:...
Metallic phosphate binders require acidity to dissociate the free metallic ion and bind phosphorus. Altered gastric may, therefore, influence phosphate-binding efficacy. We evaluated clinical effect of pantoprazole on efficacy calcium carbonate in haemodialysis patients. The study had two parts: a cross-sectional (n = 67), an interventional, crossover, double-blind, randomized, placebo-controlled trial 26 patients given 40 mg daily or placebo for consecutive 6-week periods. showed no...
To describe the distribution of body mass index (BMI) and estimate prevalence potential chronic energy deficiency (CED) obesity in Aborigines remote communities (ARC) Top End Northern Territory, Australia. Centile charts were constructed for BMI from 1,631 sets measurements 1,138 Aborigines, aged five to 77 years, three on Tiwi Islands, using Cole's IMS method. These compared with European, American white black reference charts. The prevalences CED also corresponding values a national...
Albuminuria is a widely recognized marker of renal disease and cardiovascular risk. This especially true in Aboriginal Australians living remote communities who suffer high rates end-stage mortality. During survey risk factors for one such community, an association between common polymorphism at codon 72 (Arg/Pro) the p53 gene markers was sought. A cross-sectional community including 217 people performed. Genotypes were distributed Hardy-Weinberg equilibrium, with p53Arg allele frequency...