A5078857171- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Dialysis and Renal Disease Management
- Childhood Cancer Survivors' Quality of Life
- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- Mental Health and Patient Involvement
- Adolescent and Pediatric Healthcare
- Patient-Provider Communication in Healthcare
- Geriatric Care and Nursing Homes
- Renal Transplantation Outcomes and Treatments
- Health Policy Implementation Science
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Single-cell and spatial transcriptomics
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Poisoning and overdose treatments
- Chronic Disease Management Strategies
- Delphi Technique in Research
- Gender, Feminism, and Media
- Neonatal Respiratory Health Research
- Histone Deacetylase Inhibitors Research
The University of Sydney
2024-2025
Children's Hospital at Westmead
2024-2025
Curtin University
2021-2025
University of Bari Aldo Moro
2025
Sydney Local Health District
2024
The Kids Research Institute Australia
2018-2024
The University of Melbourne
2023
The University of Western Australia
2018-2021
Abstract Infants with KMT2A -rearranged B-cell acute lymphoblastic leukemia (ALL) have a dismal prognosis. Survival outcomes remained static in recent decades despite treatment intensification and novel therapies are urgently required. infant ALL cells characterized by an abundance of promoter hypermethylation exhibit high BCL-2 expression, highlighting potential for therapeutic targeting. Here, we show that hypomethylating agents vitro additivity when combined most conventional...
Abstract Rationale & Objective Children and adolescents with chronic kidney disease (CKD) are at risk of depression other mental health conditions, which can impair quality life, the capacity for self-management adherence to treatment, overall health. This study aimed describe perspectives patients caregivers on in children across all stages CKD. Study Design Qualitative study. Settings Participants A secondary analysis a consensus, multi-stage inclusive process designed establish core...
The microenvironments of leukemia and cancer are critical for multiple stages malignancies, they an attractive therapeutic target. While skeletal abnormalities commonly seen in children with acute lymphoblastic (ALL) prior to initiating osteotoxic therapy, little is known about the alterations bone marrow microenvironment during leukemogenesis. Therefore, this study, we focused on development precursor-B cell ALL (pre-B ALL) immunocompetent BCR-ABL1+ model. Here show that hematopoiesis was...
Abstract The bone marrow microenvironment (BMM) plays a key role in leukemia progression, but its molecular complexity pre-B cell acute lymphoblastic (B-ALL), the most common cancer children, remains poorly understood. To gain further insight, we used single-cell RNA sequencing to characterize kinetics of murine BMM during B-ALL progression. Normal pro- and cells were found be affected at earliest stages disease this was associated with changes expression genes regulated by AP1-transcription...
Background Infants with KMT2A -rearranged B-cell precursor acute lymphoblastic leukemia (ALL) have poor outcomes. There is an urgent need to identify novel agents improve survival. Proteasome inhibition has emerged as a promising therapeutic strategy for several hematological malignancies. The aim of this study was determine the preclinical efficacy selective proteasome inhibitor carfilzomib, infants ALL. Methods Eight infant ALL cell lines were extensively characterized immunophenotypic and...
Abstract In response to rapid and substantial increases in rates of e-cigarette use among young people, Australia’s Therapeutic Goods Administration (TGA) made changes the regulations governing nicotine vaping products. As part regulatory change process, Australians were invited comment on proposed regulations, which featured introduction a prescription model for To inform strategies enhance compliance with tightened this study examined submissions by self-reported users TGA’s public...
Components of the bone marrow microenvironment (BMM) have been shown to mediate way in which leukemia develops, progresses and responds treatment. Increasing evidence shows that leukemic cells hijack BMM, altering its functioning establishing leukemia-supportive interactions with stromal immune cells. While previous work has highlighted functional defects mesenchymal stem cell (MSC) population from BMM acute leukemias, thorough characterization molecular profiling MSCs pre-B lymphoblastic...
Abstract The rarity of the mesenchymal stem cell (MSC) population poses a significant challenge for MSC research. Therefore, these cells are often expanded in vitro, prior to use. However, long-term culture has been shown alter primary properties. Additionally, early passage MSCs assumed represent situ, however, little research done support this. Here, we compared transcriptomic profiles murine freshly isolated from bone marrow those that had 10 days. We identified single extensively altered...