A5044863806- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Surface Modification and Superhydrophobicity
- Adhesion, Friction, and Surface Interactions
- Advanced Sensor and Energy Harvesting Materials
- Radiopharmaceutical Chemistry and Applications
- Estrogen and related hormone effects
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Gas Sensing Nanomaterials and Sensors
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Prostate Cancer Diagnosis and Treatment
- Palliative Care and End-of-Life Issues
- Immunotherapy and Immune Responses
- Inflammatory Bowel Disease
- Cell Adhesion Molecules Research
- Mental Health and Patient Involvement
- Cancer, Hypoxia, and Metabolism
- Fluid Dynamics and Heat Transfer
- Mesenchymal stem cell research
- Conducting polymers and applications
- Monoclonal and Polyclonal Antibodies Research
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes Management and Education
Children's Hospital at Westmead
2024-2025
Methodist Hospital
2025
The University of Sydney
2024-2025
University of Toronto
1998-2023
University Health Network
2019-2023
BC Cancer Agency
2018-2022
Sunnybrook Health Science Centre
2022
University of Michigan
2022
Health Sciences Centre
2022
Alpine Immune Sciences (United States)
2017-2020
Atherosclerosis (AS) is a major contributor to vascular disorders and represents significant risk human health. Currently, first-line pharmacotherapies are associated with substantial side effects, the development of atherosclerosis closely linked dietary factors. This study evaluated effects supplement, EsV3, on AS in apolipoprotein E (ApoE) −/− model mice. The utilized high-fat diet-induced ApoE−/− hyperlipidemic mouse model. EsV3 was administered prophylactic (P-EsV3) therapeutic regimens...
Neuroendocrine prostate cancer (NEPC) is a lethal subtype of arising mostly from adenocarcinoma via neuroendocrine transdifferentiation following androgen deprivation therapy. Mechanisms contributing to both NEPC development and its aggressiveness remain elusive. In light the fact that hyperchromatic nuclei are distinguishing histopathologic feature NEPC, we utilized transcriptomic analyses our patient-derived xenograft (PDX) models, multiple clinical cohorts, genetically engineered mouse...
Abstract Low‐rate dynamic contact angles of 13 liquids on a polystyrene polymer are measured by an automated axisymmetric drop shape analysis – profile (ADSA‐P). It is found that 7 yielded non‐constant angles, and/or dissolved the contact. From experimental other 6 liquids, it liquid‐vapor surface tension times cosine angle changes smoothly with tension, i.e. γ lv cosθ depends only for given solid (or tension). This pattern in harmony those from inert and non‐inert (polar non‐polar) surfaces...
With the increasing use of intensity-modulated radiation therapy (IMRT) for treatment head and neck cancer, oncologists are expected to have an in-depth knowledge computed tomographic (CT) magnetic resonance (MR) imaging anatomy this region be able accurately characterize tumor extent define organs at risk potential injury. The brachial plexus is a complex anatomic structure in adjacent diseased nodes elective nodal volumes (ie, areas that prophylactically treated because they high...
Acute graft-versus-host disease (aGVHD) remains a major complication of allogeneic hematopoietic cell transplantation (HCT). CD146 and CCR5 are proteins that mark activated T helper 17 (Th17) cells. The Th17 phenotype is promoted by the interaction receptor ICOS on cells with ligand (ICOSL) dendritic (DCs). We performed multiparametric flow cytometry in cohort 156 HCT recipients conducted experiments aGVHD murine models to understand role ICOSL+ DCs. observed an increased frequency...
Abstract Introduction Sleep disruption is associated with astrocyte activation and impaired cognition in model organisms. However, the relationship among sleep, activation, humans uncertain. Methods We used RNA‐seq to quantify prefrontal cortex expression of a panel human activated marker genes 1076 older adults Religious Orders Study Rush Memory Aging Project, 411 whom had multi‐day actigraphy prior death. related this rest fragmentation, proxy for sleep longitudinal cognitive function....
Low-rate dynamic contact angles of 14 liquids on a poly[styrene-alt-(hexyl/10-carboxydecyl(90/10)maleimide)] P[S-(H/CM)] were measured by means an automated axisymmetric drop shape analysis-profile (ADSA-P). It was found that 9 yield non-constant angles, and/or dissolve the polymer. From experimental remaining 5 liquids, it product liquid-vapour surface tension and cosine angle changes smoothly with tension, i. e. γlv cos θ depends only for given solid (or tension). This pattern is in...
Summary Recently, methods have been developed to culture dissociated tracheal epithelial (TE) cells. Attempts were made infect these cells with mouse cytomegalovirus (MCMV) see if the share characteristics of infection MCMV-infected organ cultures. When isolated TE incubated MCMV at multiplicities between 0.10 and 2.0, no or minimal resulted. Centrifugation virus onto cell sheets also resulted in only infection. If embryo fibroblasts added cultures cells, however, subsequently became...
Background: Systemic and local inflammatory processes have a key, mainly detrimental role in the pathophysiology of acute lung injury (ALI). The present study was designed to determine whether human umbilical cord mesenchymal stem cells (UCMSC) are able act on CD4+CD25+Foxp3+Treg lead an improvement ALI.
Abstract Background and Objective Prostate cancer (PCa) is a leading cause of mortality in men, with neuroendocrine prostate (NEPC) representing particularly resistant subtype. The role transcription factors (TFs) the progression from prostatic adenocarcinoma (PRAD) to NEPC poorly understood. This study aims identify analyze lineage-specific TF profiles PRAD illustrate their dynamic shifts during NE transdifferentiation. Methods A novel algorithmic approach was developed evaluate weighted...