A5029941722- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Viral-associated cancers and disorders
- Cancer Immunotherapy and Biomarkers
- Hematopoietic Stem Cell Transplantation
- T-cell and Retrovirus Studies
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Transplantation: Methods and Outcomes
- Chronic Lymphocytic Leukemia Research
- Renal Transplantation Outcomes and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Multiple Myeloma Research and Treatments
- Single-cell and spatial transcriptomics
- Mesenchymal stem cell research
- Cancer Cells and Metastasis
- Adipokines, Inflammation, and Metabolic Diseases
- Protease and Inhibitor Mechanisms
- Sarcoma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Adipose Tissue and Metabolism
Oslo University Hospital
2019-2023
University of Oslo
2019-2023
Cancer Registry of Norway
2023
University of Groningen
2011-2021
University Medical Center Groningen
2011-2021
Indiana University School of Medicine
2016-2020
Indiana University – Purdue University Indianapolis
2016-2020
Indiana University Health
2016
Fred Hutch Cancer Center
2016
University of Minnesota
2016
To identify diagnostic and prognostic markers of chronic graft-versus-host disease (cGVHD), the major cause morbidity mortality after allogeneic hematopoietic cell transplantation (HCT).Using a quantitative proteomics approach, we compared pooled plasma samples obtained at matched time points HCT (median, 103 days) from 35 patients with cGVHD 18 without (data are available via ProteomeXchange identifier PXD002762). Of 105 proteins showing least 1.25-fold difference in expression, 22 were...
Abstract In chronic lymphocytic leukemia (CLL), signaling through several prosurvival B cell surface receptors activates the PI3K pathway. Idelalisib is a highly selective (PI3Kδ) isoform-specific inhibitor effective in relapsed/refractory CLL and follicular lymphoma. However, severe autoimmune adverse effects association with use of idelalisib treatment CLL, particularly as first-line therapy, gave indications that may preferentially target suppressive function regulatory T cells (Tregs)....
Antigen presentation by tumor cells in the context of Human Leukocyte (HLA) is generally considered to be a prerequisite for effective immune checkpoint inhibitor therapy. We evaluated cell surface HLA class I, II and cytoplasmic HLA-DM staining immunohistochemistry (IHC) 389 classical Hodgkin lymphomas (cHL), 22 nodular lymphocyte predominant (NLPHL), 137 diffuse large B-cell (DLBCL), 39 primary central nervous system (PCNSL) 19 testicular lymphomas. describe novel mechanism escape which...
The pathogenesis of classical Hodgkin lymphoma (cHL) involves environmental and genetic factors. To explore the role human leukocyte antigen (HLA) genes, we performed a case-control genotyping study in 338 Dutch cHL patients using PCR-based sequence-specific oligonucleotide probe (SSOP) hybridization approach. allele frequencies were compared to HLA typings more than 6,000 controls. age varied between 13 81 years with median 35 years. Nodular sclerosis subtype was most common (87%) EBV...
Improved diagnostic methods are needed for bronchiolitis obliterans syndrome (BOS), a serious complication after allogeneic hematopoietic cell transplantation (HCT) and lung transplantation. For protein candidate discovery, we compared plasma pools from HCT recipients with BOS at onset (n = 12), pulmonary infection 16), chronic graft-versus-host disease without involvement 15) no complications 15). Pools were labeled different tags (isobaric relative absolute quantification), two software...
Tumor-infiltrating regulatory T cells (Tregs) contribute to an immunosuppressive tumor microenvironment. Despite extensive studies, the prognostic impact of tumor-infiltrating Tregs in B-cell non-Hodgkin lymphomas (B-NHLs) remains unclear. Emerging studies suggest substantial heterogeneity phenotypes and suppressive capacities Tregs, emphasizing importance understanding Treg diversity need for additional markers identify highly Tregs. Here, we applied single-cell RNA sequencing T-cell...
HLA-A2 protects from EBV+ classical Hodgkin lymphoma (cHL) in Western Europe, but it is unknown whether this protective effect also exists the Chinese population. We investigated association of and specific common well documented subtypes with EBV stratified cHL patients (n = 161) northern part China. Quantitative-PCR sequence-based subtyping was performed to identify positive samples their subtypes. 67 (42%) were EBV+. There no significant differences percentages positivity between controls...
Acute graft-versus-host disease (aGVHD) remains a major complication of allogeneic hematopoietic cell transplantation (HCT). CD146 and CCR5 are proteins that mark activated T helper 17 (Th17) cells. The Th17 phenotype is promoted by the interaction receptor ICOS on cells with ligand (ICOSL) dendritic (DCs). We performed multiparametric flow cytometry in cohort 156 HCT recipients conducted experiments aGVHD murine models to understand role ICOSL+ DCs. observed an increased frequency...
Abstract Background: VB N-01 is an open label phase 1/2a basket trial to evaluate safety, feasibility, and immunogenicity of a therapeutic DNA cancer vaccine VB10.NEO in patients with locally advanced or metastatic solid cancers. Each contains up 20 neoepitopes selected by the proprietary AI platform NeoSELECT designed target antigen presenting cells using Nykode’ s modular known as Vaccibody™. Patients Methods: The enrolled cancers (renal cell carcinoma, urothelial cancer, non-small lung...
Abstract Pancreas and islet transplantation (PTx) are currently the only curative treatment options for type 1 diabetes. CD4+ CD8+ T cells play a pivotal role in graft function, rejection, survival. However, characterization of immune cell status from patients with without rejection pancreas is lacking. We performed multiparameter phenotyping PTx prior to y post-PTx nonrejectors histologically confirmed rejectors. Our results suggest that associated presence elevated levels activated...
Several human leukocyte antigen (HLA) alleles are strongly associated with susceptibility to classic Hodgkin lymphoma (cHL), also in subgroups stratified for presence of the Epstein–Barr virus (EBV). We tested hypothesis that pressure on cHL tumour cells lose HLA expression is alleles. A meta-analysis was carried out identify consistent protective and risk a combined cohort 839 patients from Netherlands United Kingdom. Tumour cell studied 338 cases these two cohorts correlated specific...
Question: In large genome wide association studies, the human leukocyte antigen (HLA) region has been shown to be strongest contributor genetic susceptibility in both Epstein Barr virus (EBV) positive and negative classical Hodgkin lymphoma (cHL). EBV+ cHL this attributed HLA-A1 type, while HLA-A2 is protective. The aim of study comprehensively type HLA class I II genes EBV- cases.