A5101420781- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Cell death mechanisms and regulation
- Hydraulic Fracturing and Reservoir Analysis
- PARP inhibition in cancer therapy
- Ubiquitin and proteasome pathways
- Drilling and Well Engineering
- Viral-associated cancers and disorders
- Rock Mechanics and Modeling
- Calpain Protease Function and Regulation
- Medical Image Segmentation Techniques
- Cancer-related Molecular Pathways
- Remote Sensing and Land Use
- Radiomics and Machine Learning in Medical Imaging
- Wnt/β-catenin signaling in development and cancer
- T-cell and B-cell Immunology
- Helicobacter pylori-related gastroenterology studies
- Ferroptosis and cancer prognosis
- AI in cancer detection
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Galectins and Cancer Biology
- CRISPR and Genetic Engineering
- Chronic Lymphocytic Leukemia Research
- Nuclear Structure and Function
Dalhousie University
2022-2025
University Medical Center Groningen
2021-2022
University of Groningen
2021-2022
Sichuan Agricultural University
2021
China Medical University
2019
Mortality from colorectal cancer (CRC) is significant, and novel CRC therapies are needed. A pseudokinase MLKL typically executes necroptotic cell death, inactivation protects cells such death. However, we found unexpectedly that gene knockout enhanced death caused by a protein synthesis inhibitor homoharringtonine used for chronic myeloid leukemia treatment. In an effort to explain this finding, observed reduces the basal autophagy renders critically dependent on presence of VPS37A,...
Abstract Drugs causing ferroptosis, iron-mediated cell death, represent promising tools for cancer treatment. While exploring the effect of these drugs on breast (BC), we found that a ferroptosis-inducing drug erastin dramatically inhibits tumorigenicity human BC cells in mice but when used at concentration known to effectively kill other types only modestly reduces such growth 2D monolayer culture. BCs grow vivo as 3D masses, and ferroptosis inducers sulfasalazine inhibit multiple lines...
The expression and activity of CCAAT/enhancer-binding protein α (C/EBPα) are involved in sumoylation modification, which is critical to divert normal cells from differentiation proliferation. However, the role underlying mechanism C/EBPα cancer poorly understood. Human MORC2 (microrchidia family CW-type zinc-finger 2), a member MORC proteins containing domain. Here, we found that interacted with TE-III domain C/EBPα, overexpression promoted wild-type its subsequent degradation, didn't...
Abstract A significant proportion of breast cancers are driven by ErbB2/Her2 oncoprotein that they overexpress. These malignancies typically treated with various ErbB2-targeted drugs, but many such develop resistance to these agents and become incurable. Conceivably, treatment ErbB2-positive could be facilitated use blocking oncogenic signaling mechanisms downstream ErbB2. However, current understanding is limited. The ability solid tumor cells resist anoikis, cell death triggered detachment...
Commercial production from hydrocarbon-bearing reservoirs with low permeability usually requires the use of horizontal well and hydraulic fracturing for improvement fluid diffusivity in matrix. The process involves injection viscous fracture initiation propagation, which alters poroelastic behaviors formation causes interference. Previous modeling studies focused on effect interference multicluster geometry, while related productivity wells is not studied. This study presents a workflow that...
Genetic variants in the HLA region are strongest risk factors for developing Hodgkin lymphoma (HL), suggesting an important role antigen presentation. This is supported by another HL-associated genomic which contains loci of two enzymes that process endogenous proteins to peptides be presented class I, i.e., endoplasmic reticulum aminopeptidase 1 (ERAP1) and ERAP2. We hypothesized ERAP I type interact HL susceptibility, as shown previously several autoimmune diseases. detected ERAP1 ERAP2...
Tumor cells of classic Hodgkin lymphoma (cHL) are derived from antigen presenting B that infected by Epstein Barr virus (EBV) in ~30% patients. Polymorphic Killer cell immunoglobulin-like receptors (KIRs) expressed on NK interact with human leukocyte (HLA) class I and play a key role immune surveillance against virally tumor cells. We investigated the effect KIR types cHL susceptibility overall (n=211) EBV-stratified subgroups using Dutch GoNL cohort as controls (n=498). The frequency...
Several human leukocyte antigen (HLA) alleles are strongly associated with susceptibility to classic Hodgkin lymphoma (cHL), also in subgroups stratified for presence of the Epstein–Barr virus (EBV). We tested hypothesis that pressure on cHL tumour cells lose HLA expression is alleles. A meta-analysis was carried out identify consistent protective and risk a combined cohort 839 patients from Netherlands United Kingdom. Tumour cell studied 338 cases these two cohorts correlated specific...
Abstract Mortality from colorectal cancer (CRC) is significant, and novel CRC therapies are needed. A pseudokinase MLKL typically executes necroptotic cell death, inactivation protects cells such death. However, we found unexpectedly that gene knockout enhanced death caused by a protein synthesis inhibitor homoharringtonine used for chronic myeloid leukemia treatment. In an effort to explain this finding, observed reduced autophagy rendered critically dependent on the presence of VPS37A,...
Successful hydraulic fracturing is very important in the development of hydrocarbon-bearing formations. The loading introduced by causes deformation and failure, which are related to damage accumulation fracture initiation process. This study employs a numerical model that considers dynamic elastoplastic behaviors rocks under influence impact loads. acceleration wave propagation quantified using model. A time integration algorithm used ensure accuracy stability. effects rate, location,...
This paper uses the methods of picture recognition, sketch map and questionnaire to understand citizens’ evaluation Luzhou’s urban environment, obtain overall city image influencing factors explore spatial composition characteristics Luzhou.Based on analysis deficiencies in process development, this puts forward some appropriate suggestions construct a good luzhou space.