A5041064075- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Mathematics and Applications
- CAR-T cell therapy research
- Intraocular Surgery and Lenses
- History and Theory of Mathematics
- Immunotherapy and Immune Responses
- Ocular Diseases and Behçet’s Syndrome
- Glaucoma and retinal disorders
- Immunodeficiency and Autoimmune Disorders
- Retinal and Optic Conditions
- Ophthalmology and Visual Impairment Studies
- graph theory and CDMA systems
- Advanced Mathematical Theories
- Visual perception and processing mechanisms
- Ophthalmology and Eye Disorders
- Markov Chains and Monte Carlo Methods
- Stochastic processes and financial applications
- Cerebrovascular and Carotid Artery Diseases
- Corneal surgery and disorders
- Stochastic processes and statistical mechanics
- Retinal Imaging and Analysis
- Gaussian Processes and Bayesian Inference
Alpine Immune Sciences (United States)
2017-2024
Amgen (United States)
2009
La Grange Public Library
2002
Targeted Medical Pharma (United States)
1997-1999
Seattle University
1997
Loyola University Chicago
1984-1993
University of Chicago
1991-1992
Loyola University Medical Center
1983
Roosevelt University
1973-1978
Objective Dysregulated APRIL/BAFF signaling is implicated in the pathogenesis of multiple autoimmune diseases, including systemic lupus erythematosus and nephritis. We undertook this study to develop evaluate a high‐affinity antagonist overcome clinical limitations existing B cell inhibitors. Methods A variant TACI‐Fc generated by directed evolution showed enhanced binding for both APRIL BAFF was designated povetacicept (ALPN‐303). Povetacicept compared wild‐type (WT) related molecules vitro...
• We describe a patient with an isolated mesencephalic dorsal tegmental infarct affecting the oculomotor nuclear complex and medial longitudinal fasciculus, documented by high-resolution computed tomography, after undergoing percutaneous transluminal coronary artery angioplasty. Clinically, exhibited bilateral ptosis, internuclear ophthalmoplegia, transient convergence retractory nystagmus, minimal somnolence. believe combined clinical radiological findings favor presence of caudal, dorsal,...
Corneoscleral limbal masses were created in ten rabbit eyes and upper eyelid colobomas produced an additional eyes. The resultant changes corneal curvature recorded over a one-month period using streak retinoscopy photokeratometry. By these methods, we have determined that forces at or near the corneoscleral limbus can produce lead to refractive errors primarily of astigmatic variety. There is shift axis astigmatism towards meridian 90 degrees away from external force increase along where...
Acute graft-versus-host disease (aGVHD) remains a major complication of allogeneic hematopoietic cell transplantation (HCT). CD146 and CCR5 are proteins that mark activated T helper 17 (Th17) cells. The Th17 phenotype is promoted by the interaction receptor ICOS on cells with ligand (ICOSL) dendritic (DCs). We performed multiparametric flow cytometry in cohort 156 HCT recipients conducted experiments aGVHD murine models to understand role ICOSL+ DCs. observed an increased frequency...
CD28 and inducible T cell costimulator (ICOS) appear to have nonredundant roles in activation adaptive immunity. We undertook this study characterize vitro vivo the therapeutic potential of acazicolcept (ALPN-101), an Fc fusion protein a human variant ICOS ligand (ICOSL) domain designed inhibit both costimulation, inflammatory arthritis.Acazicolcept was compared with inhibitors either or pathways (abatacept belatacept [CTLA-4Ig], prezalumab [anti-ICOSL monoclonal antibody]) receptor binding...
Immunoglobulin superfamily member (IgSF) proteins play a significant role in regulating immune responses with surface expression on all cell subsets, making the IgSF an attractive family of for therapeutic targeting human diseases. We have developed directed evolution platform capable engineering domains to increase affinities cognate ligands and/or introduce binding non-cognate ligands. Using this scientific platform, ICOSL been derived enhanced ICOS and additional high-affinity receptor,...
Adoptive immunotherapy with ex vivo-expanded antigen-specific cytotoxic T lymphocytes (CTLs) has been shown to clear viral infections and eliminate tumors in murine models. Clinical trials have also reported promising data for the use of adoptive treat cytomegalovirus (CMV) Epstein-Barr (EBV) bone marrow transplant recipients. For these indications, need CTLs is often short lived, until immune system reconstituted by donor transplant. In chronic disease settings, increased longevity...
<h3>Objective</h3> BAFF and APRIL signal through TACI, BCMA, and/or BAFF-R, play important roles in the activation, differentiation, survival of B cells, particularly antibody-secreting as well T cells innate immune cells. Therapeutic agents targeting have demonstrated promising clinical potential systemic lupus erythematosus (SLE), nephritis (LN), other cell-related diseases; however, these inhibit only BAFF, APRIL, or predominantly more potent inhibition both cytokines is likely required...
Pretreatment with topical nonsteroidal anti-inflammatory drugs is common practice to maintain maximal pupil dilation for cataract surgery. Most surgeons also inject a cholinergic agent intracamerally miosis after intraocular lens insertion. We evaluated the effects of suprofen and flurbiprofen on induced by anterior chamber irrigation either acetylcholine or carbachol. One eye 30 pigmented rabbits was dilated cyclopentolate HCl phenylephrine HC1. Three groups, each composed ten eyes,...
For a single-type Galton—Watson branching process with mean less than one and finite second moment, we establish an upper bound for the of associated Yaglom limit. This is attained if only generating function linear.
Purpose: Combined inhibition of CD28 and inducible T cell costimulator (ICOS) pathways with acazicolcept (ALPN-101) represents a potential new treatment for uveitis. Here, we evaluate preclinical efficacy using experimental autoimmune uveitis (EAU) in Lewis rats. Methods: Efficacy was tested 57 rats treated either systemic (subcutaneous) or local (intravitreal) administration compared to matched Fc-only control corticosteroid. Impact on assessed clinical scoring, optical coherence tomography...
When the authors met at a geometry conference Easter 1999, they found that each had discovered and investigated an elegant result (Theorem 2.1) about octagon inscribed in conic, Larry Evans algebraically John Rigby synmetically. This turned out to be rediscovery, as been discussed by E. H. Lockwood Gazette 1967, article complements present article. Also, almost century earlier 1872, posed somewhat imprecisely T. Wilkinson problem Educational Times . There is surprising connection between...
For a single-type Galton—Watson branching process with mean less than one and finite second moment, we establish an upper bound for the of associated Yaglom limit. This is attained if only generating function linear.
Background: BAFF and APRIL are TNF superfamily members that form homo- heteromultimers bind TACI BCMA on B cells; also binds BAFF-R. support cell development, differentiation, survival, particularly for plasmablasts plasma cells, play critical roles in the pathogenesis of cell-related autoimmune diseases. In nonclinical models, inhibition either or alone mediates relatively modest effects, whereas their co-neutralization dramatically reduces function, including antibody production. Fc...