A5009187580- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury Research
- Cancer Treatment and Pharmacology
- Cerebral Palsy and Movement Disorders
- Botulinum Toxin and Related Neurological Disorders
- Cancer survivorship and care
- Cancer-related cognitive impairment studies
- Chemotherapy-related skin toxicity
- Pain Mechanisms and Treatments
- Pituitary Gland Disorders and Treatments
- Musculoskeletal pain and rehabilitation
- Muscle activation and electromyography studies
- EEG and Brain-Computer Interfaces
- Peripheral Neuropathies and Disorders
- Nerve Injury and Rehabilitation
- Cardiac Arrest and Resuscitation
- Lymphatic System and Diseases
- Dementia and Cognitive Impairment Research
- Brain Metastases and Treatment
- Anesthesia and Pain Management
- Pain Management and Opioid Use
- Growth Hormone and Insulin-like Growth Factors
- Management of metastatic bone disease
- Neurobiology of Language and Bilingualism
- Transcranial Magnetic Stimulation Studies
University of California, San Francisco
2016-2025
San Francisco VA Health Care System
2018-2025
San Francisco VA Medical Center
2008-2023
Indiana University School of Medicine
2014-2018
Foundation for Physical Medicine and Rehabilitation
2016
New York University
2016
Stanford University
2016
Turner Consulting Group (United States)
2012
University of California System
2012
American Physical Therapy Association
2003-2010
Adrenalectomy of adult male rats resulted in a nearly complete loss hippocampal granule cells 3 to 4 months after surgery. Nissl and immunocytochemical staining neurons revealed that the cell was selective; there no apparent pyramidal or γ-amino butyric acid (GABA)-, somatostatin-, neuropeptide Y-, calcium binding protein-, parvalbumin-containing interneurons. The CA1 adrenalectomized animals exhibited normal electrophysiological responses afferent stimulation, whereas evoked dentate gyrus...
Technology to restore the ability communicate in paralyzed persons who cannot speak has potential improve autonomy and quality of life. An approach that decodes words sentences directly from cerebral cortical activity such patients may represent an advancement over existing methods for assisted communication.We implanted a subdural, high-density, multielectrode array area sensorimotor cortex controls speech person with anarthria (the loss articulate speech) spastic quadriparesis caused by...
Neurotensin was localized in the hypothalamic tissues of adult Sprague-Dawley rats by immunoperoxidase techniques. Visualization perikarya greatly enhanced intraventricular administration colchicine. Many containing neurotensin-like immunoreactivity were seen medial preoptic area, periventricular hypothalamus, parvocellular portion paraventricular nucleus, arcuate and lateral hypothalamus perifornical area. There moderate numbers cell bodies ventral anterior dorsomedial posterior...
Abstract Immunocytochemical procedures on thick, unembedded tissue sections were used to study the localization of LHRH neurons and fibers in diencephalon mesencephalon rhesus pigtailed macaques. Cell bodies visualized large numbers. Much their dendritic arborization was also filled with reaction product. present preoptic area, periventricular hypothalamic zone from level anterior hypothalamus premammillary nuclei, infundibular nucleus, supraoptic several septal nervus terminalis, amygdala....
Triiodothyronine (T(3)) and thyroxine (T(4)) were measured by immunoassay in the serum thyroid hydrolysates of control (group A), mildly iodine-deficient B), severely rats C). These results correlated with changes thyroidal weight, (131)I uptake (127)I content as well distribution Pronase digests thyroid. There was a progressive increase weight at 24 h decrease iodine intake. The thyroids group B animals 44% that C 2% A. mean labeled monoiodotyrosine/diiodotyrosine (MIT/DIT) T(3)/T(4) ratios...
Pain, fatigue, sleep disturbance, and depression are common frequently co-occurring symptoms in oncology patients. This symptom cluster is often attributed to the release of proinflammatory cytokines. The purposes this study were determine whether distinct latent classes patients with breast cancer (n = 398) could be identified based on their experience cluster, these differed demographic clinical characteristics variations cytokine genes associated class membership. Three identified: "all...
Background. Studies have demonstrated the efficacy of functional electrical stimulation in management foot drop after stroke. Objective. To compare changes walking performance with WalkAide (WA) foot-drop stimulator and a conventional ankle–foot orthosis (AFO). Methods. Individuals stroke within previous 12 months residual were enrolled multicenter, randomized controlled, crossover trial. Subjects assigned to 1 3 parallel arms for weeks (6 weeks/device): arm (WA–AFO), n = 38; 2 (AFO–WA), 31;...
Robot-assisted stroke rehabilitation has become popular as one approach to helping patients recover function post-stroke. Robotic requires four important elements match the robot patient: realistic biomechanical robotic elements, an assistive control scheme enabled through human-robot interface, a task oriented program based on principles of plasticity, and objective assessment tools monitor change. This paper reports randomized clinical trial utilizing complete robot-assisted system for...
Objective-Most longitudinal studies of depressive symptoms reported mean symptom scores that tend to obscure interindividual heterogeneity in the experience.The identification subgroups patients with distinct trajectories may help identify high risk individuals who require an intervention.This study aimed breast cancer (n=398) first six months after surgery, as well predictors these trajectories.Methods-Growth mixture modeling was used latent classes based on Center for Epidemiological...
Deficits in attention and executive control are some of the most common, debilitating persistent consequences brain injuries. Understanding neural mechanisms that support clinically significant improvements, when they do occur, may help advance treatment development. Intervening via rehabilitation provides an opportunity to probe such mechanisms. Our objective was identify underlie improvements with training. We tested hypothesis intensive training enhances modulatory processing perceptual...
Background. Evidence supports peroneal nerve functional electrical stimulation (FES) as an effective alternative to ankle-foot orthoses (AFO) for treatment of foot drop poststroke, but few randomized controlled comparisons exist. Objective. To compare changes in gait and quality life (QoL) between FES AFO individuals with poststroke. Methods. In a multicenter trial (ClinicalTrials.gov #NCT01087957) unblinded outcome assessments, 495 Medicare-eligible at least 6 months poststroke wore or...
Based on the principles of neuroplasticity, purpose this crossover study was to determine if improvement in upper extremity (UE) function and independence could be achieved patients 6 months 7 years poststroke following an outpatient rehabilitation program (supervised 1.5 hours per week for 8 weeks reinforced with home gloving unaffected side attended, graded, repetitive sensory motor training activities). Twenty-one subjects (right or left hemiparesis; able walk 100 feet without a cane;...
Objective: To assess feasibility and effects of training in goal-oriented attentional self-regulation for patients with brain injury chronic executive dysfunction. Participants: Sixteen individuals mild to moderate Design: Participants were divided into 2 groups: one group completed during the first 5 weeks, followed by a brief (2-hour) educational instruction session as control midway through second weeks; other participated reverse order. Measures: Neuropsychological functional performance...
Abstract Immunofluorescence histochemistry was used to study the pathogenesis of polyneuropathy in patients with an IgM M protein. Seventeen had protein that reacted myelin‐associated glycoprotein (MAG), and their serum immunostained myelin sheaths normal peripheral nerve humans certain other species. The staining specific for idiotype abolished by prior absorption MAG. sural biopsy specimens from these 17 pathological features primary demyelination deposits on sheaths. Sural 2 reactive...
The purposes of this study were to evaluate for differences in phenotypic and genotypic characteristics women who did not develop lymphedema (LE) following breast cancer treatment. Breast patients completed a number self-report questionnaires. LE was evaluated using bioimpedance spectroscopy. Genotyping done custom genotyping array. No found between with (n = 155) without 387) the majority demographic clinical characteristics. Patients had significantly higher body mass index, more advanced...
The human arm has 7 degrees of freedom (DOF) while only 6 DOF are required to position the wrist and orient palm. Thus, inverse kinematics an a nonunique solution. Resolving this redundancy becomes critical as interacts with wearable robot solution these two coupled systems must be identical guarantee seamless integration. can formulated by defining swivel angle, rotation angle plane defined upper lower around virtual axis that connects shoulder joints. Analyzing reaching tasks recorded...
Background. Evidence supports peroneal nerve functional electrical stimulation (FES) as an effective alternative to ankle foot orthoses (AFO) for treatment of drop poststroke, but few long-term, randomized controlled comparisons exist. Objective. Compare changes in gait quality and function between FES AFOs individuals with poststroke over a 12-month period. Methods. Follow-up analysis unblinded trial (ClinicalTrials.gov #NCT01087957) conducted at 30 rehabilitation centers comparing 6...
Objective. This study aimed to determine whether the dose of learning-based sensorimotor training (LBSMT) significantly enhances gains in upper limb function patients stable post stroke. Methods. A total 45 subjects poststroke participated a 6-8-week LBSMT program varied dosage: group I (n = 18; 1×/week, 1.5 hours/visit); II 19, 3×/week, 0.75 and III 8; 4×/week, 3 hours/visit). All reinforced their with home-based practice. The primary outcome measures were functional independence, strength,...