A5031071016- Cancer survivorship and care
- Ethics in Clinical Research
- Healthcare Decision-Making and Restraints
- Childhood Cancer Survivors' Quality of Life
- Cancer-related cognitive impairment studies
- Mental Health and Psychiatry
- Ethics in medical practice
- Palliative Care and End-of-Life Issues
- Family Support in Illness
- Health Systems, Economic Evaluations, Quality of Life
- Innovations in Medical Education
- Mental Health and Patient Involvement
- Sleep and related disorders
- Schizophrenia research and treatment
- Patient-Provider Communication in Healthcare
- Tryptophan and brain disorders
- Treatment of Major Depression
- Religion, Spirituality, and Psychology
- Health, psychology, and well-being
- Neurological disorders and treatments
- Healthcare professionals’ stress and burnout
- Neuroethics, Human Enhancement, Biomedical Innovations
- Mental Health Treatment and Access
- Grief, Bereavement, and Mental Health
- Healthcare cost, quality, practices
University of Arkansas at Little Rock
2022-2024
Health and Human Development (2HD) Research Network
2024
SteelCloud (United States)
2011-2024
University of Arkansas for Medical Sciences
2022-2024
East London NHS Foundation Trust
2024
University of California, San Francisco
2009-2023
American Cancer Society
2011-2023
National Cancer Institute
2023
Stanford University
2007-2022
SUNY Upstate Medical University
2021
Context: There is a critical need for practical measures screening and documenting decisional capacity in people participating different types of clinical research.However, there are few reliable validated brief tools that could be used routinely to evaluate individuals' consent research protocol.Objective: To describe the development, testing, proposed use new instrument assess decision-making capacity: University California, San Diego Brief Assessment Capacity Consent (UBACC).The UBACC...
Pharmacy refill records were used to compare medication adherence in outpatient veterans receiving typical versus atypical antipsychotic medications.Consecutive patients meeting selection criteria and prescriptions for haloperidol (N=57), perphenazine (N=60), risperidone (N=80), olanzapine (N=63), quetiapine (N=28) over a 3-month period identified from computerized database. The hospital policy at the time of this study required failure trials least two antipsychotics before initiation an...
Unlike most other cell types, neurons preferentially metabolize glucose via the pentose phosphate pathway (PPP) to maintain their antioxidant status.Inhibiting PPP in neuronal models causes death.In rodents, inhibition of this selective dopaminergic death leading motor deficits resembling parkinsonism.Using postmortem human brain tissue, we characterized metabolism sporadic Parkinson's disease (PD), Alzheimer's (AD), and controls.AD brains showed increased nicotinamide adenine dinucleotide...
<h3>Context</h3> Considerable discussion surrounds issues related to the capacities of neuropsychiatric patients consent research, yet few empirical investigations have directly compared decisional capacity among with a serious mental illness that neurologic or medical conditions. Also, as requirements for formal assessment are becoming more common, there is clear need identify efficient screening methods. <h3>Objectives</h3> To compare 3 diagnostic groups, and examine degree which impaired...
A 2-day consensus conference was held to examine scientific and ethical issues in the application of deep brain stimulation for treating mood behavioral disorders, such as major depression, obsessive-compulsive disorder, Tourette syndrome.The primary objectives were (1) establish among participants about design future clinical trials disorders mood, behavior, thought (2) develop standards protection human subjects participating studies.Conference identified 16 key points guiding research...
Pain, fatigue, sleep disturbance, and depression are common frequently co-occurring symptoms in oncology patients. This symptom cluster is often attributed to the release of proinflammatory cytokines. The purposes this study were determine whether distinct latent classes patients with breast cancer (n = 398) could be identified based on their experience cluster, these differed demographic clinical characteristics variations cytokine genes associated class membership. Three identified: "all...
Objective-Most longitudinal studies of depressive symptoms reported mean symptom scores that tend to obscure interindividual heterogeneity in the experience.The identification subgroups patients with distinct trajectories may help identify high risk individuals who require an intervention.This study aimed breast cancer (n=398) first six months after surgery, as well predictors these trajectories.Methods-Growth mixture modeling was used latent classes based on Center for Epidemiological...
BACKGROUND A large amount of interindividual variability exists in the occurrence symptoms patients receiving chemotherapy (CTX). The purposes current study, which was performed a sample 582 oncology outpatients who were CTX, to identify subgroups based on their distinct experiences with 25 commonly occurring and demographic clinical characteristics associated subgroup membership. In addition, differences quality life outcomes evaluated. METHODS Oncology breast, gastrointestinal,...
Abstract Background Mortality rates for cancer are decreasing in patients under 60 and increasing those over years of age. The reasons these differences mortality remain poorly understood. One explanation may be that older received substandard treatment because concerns about adverse effects. Given the paucity research on multiple dimensions symptom experience oncology patients, purpose this study was to evaluate ratings occurrence, severity, frequency, distress between younger (< years)...
Abstract Background We conducted a randomized pilot trial to examine the feasibility, acceptability, and preliminary efficacy of 5 week positive affect skills intervention (LILAC: lessons in linking coping) for women with metastatic breast cancer. Additionally, we examined whether online delivery would offer comparable benefits as in‐person delivery. Methods Women cancer ( N = 39) were an intervention, or attention‐matched control. Psychological well‐being (depression [Center Epidemiologic...
The American Academy of Pediatrics and its members recognize the importance improving physician’s ability to intimate partner violence (IPV) understand effects on child health development role in continuum family violence. Pediatricians are a unique position identify IPV survivors pediatric settings, evaluate treat children exposed IPV, connect families with available local national resources. Children at increased risk being abused neglected more likely develop adverse health, behavioral,...
<h3>Background</h3> Antipsychotic medications constitute the backbone of treatment for schizophrenia. Current guidelines require clinicians to obtain patients' informed consent treatment, but few empirical studies capacity patients with schizophrenia meaningful in this context exist. This issue may be particularly relevant middle-aged and older patients, as cognitive changes associated normal aging have an adverse impact on decision-making processes. We examined range, stability, correlates...
<h3>Objective:</h3> To evaluate the relation between noncontraceptive estrogen use and skin wrinkling, dryness, atrophy. <h3>Design:</h3> Cross-sectional analysis of a national probability sample-based cohort study. <h3>Setting:</h3> Multiple community sites throughout United States. <h3>Participants:</h3> Postmenopausal women (n=3875) aged 40 years older at baseline. <h3>Measurements:</h3> Skin conditions (wrinkling, atrophy) were ascertained using uniform clinical examination by trained...
Although fatigue and sleep disturbance are prevalent symptoms in oncology patients their family caregivers, little is known about the factors that contribute to interindividual variability symptom severity ratings as well underlying biological mechanisms. In this study, we sought determine whether a functional genetic variation prominent proinflammatory cytokine, tumor necrosis factor-alpha (TNFA-308G>A [rs1800629] promoter polymorphism) was associated with overall of trajectories these...