A5052040177- Dialysis and Renal Disease Management
- Vasculitis and related conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Bipolar Disorder and Treatment
- Interpreting and Communication in Healthcare
- Oxidative Organic Chemistry Reactions
- Text Readability and Simplification
- Myofascial pain diagnosis and treatment
- Iron Metabolism and Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Sarcoidosis and Beryllium Toxicity Research
- Magnesium in Health and Disease
- Psychosomatic Disorders and Their Treatments
- Parkinson's Disease Mechanisms and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Parathyroid Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Otitis Media and Relapsing Polychondritis
- Renal Diseases and Glomerulopathies
- Neurological Complications and Syndromes
- Heart Failure Treatment and Management
- Diagnosis and Treatment of Venous Diseases
- Autoimmune Bullous Skin Diseases
- Natural Language Processing Techniques
- Pharmacological Effects and Toxicity Studies
St. Joseph’s Healthcare Hamilton
2018-2024
McMaster University
2019-2023
Population Health Research Institute
2017-2023
Pediatric Nephrology of Alabama
2017
Queen's University
2011
University of Bologna
1989
More effective and safer treatments are needed for antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis.
Rationale: Diffuse alveolar hemorrhage (DAH) is a life-threatening manifestation of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The Plasma Exchange (PLEX) and Glucocorticoids (GC) in Severe AAV (PEXIVAS;NCT00987389) trial was the largest first to enroll participants with DAH requiring mechanical ventilation. Objectives: Evaluate characteristics, treatment effects, outcomes for patients without DAH. Methods: PEXIVAS randomized 704 PLEX or no-PLEX reduced...
Background and objectives Hyperphosphatemia is common among recipients of maintenance dialysis associated with a higher risk mortality cardiovascular events. A large randomized trial needed to determine whether lowering phosphate concentrations binders improves patient-important outcomes. To inform such an effort we conducted pilot controlled trial. Design, setting, participants, & measurements We prevalent hemodialysis already receiving calcium carbonate as binder at five Canadian...
Depression and anxiety are common underrecognized in end-stage renal disease (ESRD), associated with poor outcomes reduced health-related quality of life, potentially treatable. Simple, accurate screening tools needed.We examined the operating characteristics single questions for depression from Edmonton Symptom Assessment System (ESAS) hemodialysis.Cross-sectional study.Two outpatient hemodialysis units (1 tertiary, 1 community) Hamilton, Canada.Adult prevalent patients.ESAS Hospital...
Background Anti-neutrophil cytoplasm antibody-associated vasculitis is a multisystem, autoimmune disease that causes organ failure and death. Physical removal of pathogenic autoantibodies by plasma exchange recommended for severe presentations, along with high-dose glucocorticoids, but glucocorticoid toxicity contributes to morbidity mortality. The lack robust evidence base guide the use dosing variation in practice suboptimal outcomes. Objectives We aimed determine clinical efficacy...
Background: Individuals receiving hemodialysis often experience concurrent symptoms during treatment and frequently report feeling unwell after dialysis. The degree to which intradialytic are related, specific may impair health-related quality of life (HRQoL) is uncertain. Objectives: To explore clusters, the relationship between symptom clusters with dialysis recovery time HRQoL. Design/setting: We conducted a post hoc analysis prospective cohort study 118 prevalent patients in two centers...
Abstract Background Restless legs syndrome (RLS) is common in end-stage renal disease and associated with reduced health-related quality of life. Simple accurate screening instruments are needed since RLS underdiagnosed treatable. We examined the operating characteristics questions a disease-specific measurement tool for diagnosis hemodialysis. Methods conducted cohort study prevalent adult hemodialysis patients Hamilton, Canada. The was made using 2012 Revised International Legs Syndrome...
Abstract Background The effect of hemodialysis on cardiac biomarkers is unclear. We sought to evaluate the degree and causes intradialytic variability high sensitivity troponin I (hs-TnI), galectin-3 (gal-3), heart-type fatty acid binding protein (hFABP). Methods hs-TnI, gal-3, hFABP were prospectively measured pre-dialysis post-dialysis for 1 week every month 6 months in 178 prevalent adult patients at a single center Hamilton, Canada. change from each biomarker was estimated with...
IntroductionDuring hemodialysis, proteins in the blood can decrease concentration due to diffusion, convective clearance, dialyzer adsorption, or cellular uptake, while others may increase production, release, secretion, ultrafiltration of water. We examined impact hemodialysis on protein concentrations a proteome-wide scale.MethodsA nested cohort 44 patients (25 male, 19 female) including 29 with intradialytic hypotension were selected from prospective Hemodialysis Outcomes and SympToms...
Results We present the case of a 10 year old, otherwise healthy boy, who has 6-7 history persistent chronic urticaria requiring ongoing treatment. His symptoms consist daily urticarial lesions and angioedema with frequent flares. Upper respiratory viral infections, spring/ fall season stressful events make his condition worse; however, no food or medication triggers been found so far. The initial work up included CBC, differential, TSH, thyroid antibodies, ANA, C3 C4 titers, serology for H....
Results: 273 patients with AAV (131 women, 48%) and 2717 controls were included in this study.In total 138 (50.5%) unique infections assigned for prior to the date of diagnosis vs 1266 (46.6) controls.Upper respiratory tract (URTI) pneumonia (PN) more common among going develop vs. (URI: 21.2% 16.8%,PN: 8.1% 5.3) yielding an OR 1.42 (95% CI 1.01-2.01)for URTI 1.70 1.02-2.82)for PN (Table 1).The differences only significant MPO-ANCA not PR3-ANCA associated diseases.The median time from...