A5048419464- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Zoonotic diseases and public health
- Microbial infections and disease research
- Escherichia coli research studies
- Salmonella and Campylobacter epidemiology
- Human-Animal Interaction Studies
- Clostridium difficile and Clostridium perfringens research
- Vibrio bacteria research studies
- Mycobacterium research and diagnosis
- Animal Disease Management and Epidemiology
- Antimicrobial Resistance in Staphylococcus
- Cellular transport and secretion
- Spectroscopy and Chemometric Analyses
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- Pesticide Residue Analysis and Safety
- Gut microbiota and health
- Reproductive tract infections research
- Animal Behavior and Welfare Studies
- Data-Driven Disease Surveillance
- Yersinia bacterium, plague, ectoparasites research
- Probiotics and Fermented Foods
- Animal health and immunology
- Immune responses and vaccinations
Niedersächsisches Landesgesundheitsamt
2022-2024
University of Veterinary Medicine Hannover, Foundation
2012-2023
Charité - Universitätsmedizin Berlin
2012
University of Rostock
2011
Escherichia (E.) coli producing extended-spectrum beta-lactamases (ESBLs) are an increasing problem for public health. The success of ESBLs may be due to spread ESBL-producing bacterial clones, transfer ESBL gene-carrying plasmids or exchange encoding genes on mobile elements. This makes it difficult identify transmission routes and sources bacteria. objectives this study were compare the distribution genotypic phenotypic properties E. isolates from different animal human collected in...
• Prevalence of ESBL/pAmpC-producing E. coli is highest in chicken meat. Characteristics isolates from turkey meat are significantly different to those chicken. CTX-M group among the ESBL/pAmpC producing was (26.0%) and (24.0 %). Minced beef or pork contaminated at higher frequency than pork. Vegetables only a very low level Germany. The spread extended-spectrum β-lactamases (ESBLs) Escherichia major public health issue ESBL-producing bacteria frequently reported livestock. For assessment...
Background Clostridium difficile infections (CDI) in humans range from asymptomatic carriage to life-threatening intestinal disease. Findings on C. various animal species and an overlap ribotypes (RTs) suggest potential zoonotic transmission. However, the impact of animals for human CDI remains unclear. Methods In a large-scale survey we collected 1,447 fecal samples determine occurrence small companion (dogs cats) their owners assess epidemiological links within community. The Germany-wide...
In industrialized countries, acute infectious enteric diseases are usually mild, but they can also cause death. They do so, however, at different ages. Using 2004-2008 German notification data, we computed and compared crude premature mortality [three measures of years potential life lost (YPLL)] illnesses caused by Campylobacter spp., Listeria monocytogenes, norovirus, rotavirus, non-typhoidal Salmonella Shiga toxin-producing E. coli (STEC). Among ~1.5 million notified illnesses, those...
The role of actin, class I myosins and dynamin in endocytic uptake processes is well characterized, but their during endo‐phagosomal membrane trafficking maturation less clear. In Dictyostelium , knockout myosin IB ( myoB ) leads to a defect protein recycling from endosomes back the plasma membrane. Here, we show that actin plays central morphology function pathway. Indeed, latrunculin B (LatB) induces endosome tubulation, phenotype also observed A dymA )‐null cells. Knockout impairs...
Extended spectrum beta-lactamase (ESBL)-producing Escherichia coli are an emerging problem in veterinary and human medicine. Our study concentrated on the estimation of prevalence factors associated with carriage ESBL-producing E. dogs who visited a clinic northern Germany 2017. For this reason, 1000 patients (healthy sick dogs) were tested, resulting samples originating from rectal swabs. Additional data collected using self-reported questionnaire that was completed by dog owner. Factors...
The risk to die from an infectious disease in Germany has been continuously decreasing over the last century. Since infections are, however, not only causes of death but factors for diseases like cardiovascular diseases, it is essential monitor and analyze their prevalence frequency, especially consideration increased life expectancy. To gain more knowledge about as implications on condition change immune status, German National Cohort (GNC), a population-based prospective cohort study, will...
Antimicrobial resistance in livestock is a matter of general concern. To develop hygiene measures and methods for prevention control, epidemiological studies on population level are needed to detect factors associated with antimicrobial holdings. In general, regression models used describe these relationships between environmental outcome. Besides the study design, correlation structures different outcomes antibiotic structural zero measurements outcome as well exposure side challenges model...
SUMMARY Extended-spectrum β -lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) have recently emerged in livestock and humans. Therefore, this study assessed the carriage of anterior nares associated antimicrobial resistance pig-exposed persons. Nasal swabs were enriched non-selective broth then plated on MacConkey ESBL-selective agars. Species was confirmed by matrix-assisted laser-desorption ionization–time-of-flight mass spectrometry (MALDI-ToF MS). Antimicrobial susceptibility...
SUMMARY As part of the preparation a large cohort study in entire German population, this examined feasibility cat and dog owners collecting nasal oral swabs their animals at home as method assessing exposure to zoonoses. In veterinary clinics Hannover, Germany, 100 pet were recruited. Nasal pets taken by veterinarian clinic took home. Swabs analysed regarding bacterial growth compared (owner vs . vet) using Cohen's kappa McNemar's test. The return rate kits was 92%, 77% thought it...
Im Rahmen das Projektes "Connect One Health Data" wurde recherchiert, welche Routinedatensammlungen zu zoonotischen Erregern in Niedersachsen existieren und Informationen enthalten sind. Die identifizierten Datenquellen, z.B. humanen oder tierischen Infektionsmeldefällen, Nachweisen Lebensmitteln Badegewässern, wurden anhand eines Erhebungsbogens systematisch beschrieben.
Two-thirds of human infectious diseases are zoonotic and routine data collections exist for each sector (human, veterinary, environmental). However, these operate separately the collected not integrated across sectors. Publicly available information on in terms metadata is sparse. The aim was to create an inventory Federal State Lower Saxony, Germany. A systematic screening existing from veterinary sectors carried out basis expert interviews. standardised template used collect relevant...
Locally, the introduction of measures during times a pandemic emergency is embodied in containment plan created by Robert Koch Institute 2017. In addition to central indicators such as incidence rates and number deaths, various are used at local level assess situation. So far, there hasn't been analyses availability perceived relevance surveillance manage SARS-CoV-2 German task forces.This study examined whether decision-makers had access surveillance-related way that they could be make...