A5100679167- Cancer, Hypoxia, and Metabolism
- Global Cancer Incidence and Screening
- Viral-associated cancers and disorders
- Economic and Financial Impacts of Cancer
- Ovarian cancer diagnosis and treatment
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Screening and Detection
- Cancer Risks and Factors
- Cancer-related Molecular Pathways
- HIV/AIDS drug development and treatment
- Cancer, Lipids, and Metabolism
- Angiogenesis and VEGF in Cancer
- Immune cells in cancer
- Hepatitis C virus research
- Early Childhood Education and Development
- Polyomavirus and related diseases
- Water Quality and Pollution Assessment
- Cancer Immunotherapy and Biomarkers
- Uterine Myomas and Treatments
- Renal Transplantation Outcomes and Treatments
- Distributed and Parallel Computing Systems
- Long-Term Effects of COVID-19
- Lung Cancer Research Studies
- COVID-19 Clinical Research Studies
- Cervical Cancer and HPV Research
Manav Rachna International Institute of Research and Studies
2024
Duke University
2021-2024
Stanford University
1989-2024
Jazan University
2024
The Ohio State University
2024
Sarojini Naidu Medical College
2023
Baba Raghav Das Medical College
2023
Banasthali University
2023
Hackensack University Medical Center
2020-2022
Trinity College
2021-2022
Background Characterizing the prevalence and persistence of symptoms associated with COVID-19 infection following hospitalization their impact is essential to planning post-acute community-based clinical services. This study seeks identify persistent in patients 35 days post-hospitalization on quality life, health, physical, mental, psychosocial function. Methods findings prospective cohort used PROMIS® Instruments life parameters consecutively enrolled between March 22 April 16, 2020, New...
Abstract Objective Head injury is an inconsistently reported risk factor for Parkinson's disease (PD). Many related variables might confound this association, such as differences in childhood and adolescent lifestyles or genetically determined risk‐taking behaviors. Twin studies circumvent some of these problems, because twins are environmentally much more similar than typical cases control subjects. Methods We conducted a case–control study 93 twin pairs discordant PD ascertained from the...
Shared-memory multiprocessors are frequently used in a time-sharing style with multiple parallel applications executing at the same time. In such an environment, where machine load is continuously varying, question arises of how application should maximize its performance while being fair to other users system. this paper, we address issue. We first show that if number runnable processes belonging significantly exceeds effective physical processors it, can be degraded. then propose way...
Abstract Epidermal growth factor receptor (EGFR) inhibitors can decrease vascular endothelial (VEGF) expression and tumor angiogenesis. In the current study, we investigate molecular pathways by which this occurs using two drugs that have been used in clinic, gefitinib (Iressa) erlotinib (Tarceva). The VEGF SQ20B squamous cell carcinoma cells was opposed adenoviral of Akt these cells. hypoxia-inducible factor-1 (HIF-1) binding site located at approximately −1 kbp promoter not required for...
Human papillomavirus (HPV) is the most identifiable cause of head and neck squamous cell cancer (HNSCC). Compared with HPV-negative HNSCC, HPV-positive HNSCC presents at an advanced stage but significantly better survival. We created a syngeneic mouse model by transforming primary tonsil epithelial cells either HPV oncogenes or nonantigenic RNA interference strategy that affects similar oncogenic pathways.To examine effect radiation therapy on tumors in immune-competent immune-incompetent...
Objective: To assess toxicities, functional outcomes, and health-related quality of life associated with concurrent chemoradiation therapy (CRT) in patients head neck cancer.Design: Prospective retrospective outcomes study.Setting: Tertiary care institution.Patients: Participants the longitudinal Outcomes Assessment Project whose cancer was treated CRT between February 1, 2000, March 2007 (n=104).Interventions: Patients prospectively provided information, including data from 1-year most...
Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt pathway can increase vascular endothelial growth factor (VEGF) and hypoxia-inducible 1α (HIF-1α) expression. We examined the effect of nelfinavir, an HIV protease inhibitor that inhibits Akt signaling, on VEGF HIF-1α expression angiogenesis, tumor oxygenation, radiosensitization. Nelfinavir decreases under normoxia via transcription Sp1, which regulates proximal core promoter. decreased Sp1 phosphorylation binding to a probe corresponding...
Background This study examined whether the association of socioeconomic status (SES) and non–small cell lung cancer (NSCLC) stage varied by race/ethnicity health care access measures. Methods used data from 2004–2016 National Cancer Database for patients aged 18–89 years who had been diagnosed with Stage 0–IV NSCLC. Adjusted odds ratios (aORs) 95% confidence intervals (CIs) were calculated associations area‐level SES an advanced at diagnosis via multilevel, multivariable logistic regression....
Abstract Socioeconomic and racial disparities exist in access to care among patients with non-small cell lung cancer (NSCLC) the United States. Immunotherapy is a widely established treatment modality for advanced-stage NSCLC (aNSCLC). We examined associations of area-level socioeconomic status receipt immunotherapy aNSCLC by race/ethnicity facility type (academic non-academic). used National Cancer Database (2015–2016), included aged 40–89 years who were diagnosed stage III-IV NSCLC....
This cross-sectional study compares trends in estimated age-adjusted cancer mortality rates between non-Hispanic Black and White individuals the US from 2000 to 2020.
Reports of kidney transplantation (KTX) in recipients with hepatitis C virus (HCV+), human immunodeficiency (HIV+) or coinfection often do not provide adequate adjustment for donor risk factors. We evaluated paired deceased-donor kidneys (derived from the same transplanted to different recipients) which one was into a patient viral infection (HCV+, n = 1700; HIV+, 243) and other recipient without (HCV- HIV- using Scientific Registry Transplant Recipients data between 2000 2013. On...
Abstract Purpose: Preclinical and clinical studies have demonstrated that inhibition of prenylation can radiosensitize cell lines with activation Ras produce response in patients cancer. The aim this study was to determine the maximally tolerated dose dual farnesyltransferase geranylgeranyltransferase I inhibitor L-778,123 combination radiotherapy for locally advanced pancreatic Experimental Design: given by continuous intravenous infusion concomitant 59.4 Gy standard fractions. Two levels...
AbstractPurposeActivation of the phosphatidylinositol 3-kinase/Akt pathway in tumors leads to radiation resistance, and inhibition this radiosensitizes laboratory models. Several first-generation human immunodeficiency virus (HIV) protease inhibitors (HPIs) inhibit Akt activation are radiosensitizers. In order validate a biomarker activity anticipation clinical trials using HPIs combined with radiotherapy, we sought determine whether was inhibited leukocytes HIV+ patients that were already...
Local failure after chemoradiotherapy (CT-RT) significantly contributes to mortality in patients with locally advanced non-small cell lung cancer (LA-NSCLC). One approach improve local control is through targeted radiosensitization of the tumor.To evaluate dose-limiting toxic effects, maximally tolerated dose, and recommended phase 2 dose protease inhibitor nelfinavir mesylate, administered concurrently CT-RT LA-NSCLC, and, portion study, estimate objective response rate, distant rates,...
ABSTRACT Our study focuses on characterizing the highly ionized gas within Milky Way’s (MW) Circumgalactic Medium (CGM) that gives rise to ionic transitions in X-ray band 2–25 Å. Utilizing stacked Chandra/ACIS-S MEG and LETG spectra toward Quasar (QSO) sightlines, we employ self-consistent hybrid ionization code phase model our data. The are optimally described by three distinct components: warm [log (T/K) ∼ 5.5], warm-hot ∼6], hot 7.5] components. These findings confirm presence of...
We studied the effect of ionizing radiation on activation AP-1 transcription factors and regulation basic fibroblast growth factor (bFGF) gene expression in drug-sensitive human breast carcinoma (MCF-7) cells its drug-resistant variant (MCF-7/ADR) cells. Northern blot gel mobility shift assays showed that 135 cGy induced c-jun c-fos expression, binding activity, as well bFGF MCF-7/ADR In MCF-7 cells, however, we observed little/no induction activity after stress. Nevertheless, transfected...
Background: Racial disparities exist in receipt of guideline-concordant treatment ovarian cancer (OC). However, few studies have evaluated how various dimensions healthcare access (HCA) contribute to these disparities. Methods: We analyzed data from non-Hispanic (NH)–Black, Hispanic, and NH-White patients with OC diagnosed 2008 2015 the SEER-Medicare database defined HCA as affordability, availability, accessibility, measured aggregate scores created factor analysis. Receipt surgery...
Importance Poor health care access (HCA) is associated with racial and ethnic disparities in ovarian cancer (OC) survival. Objective To generate composite scores representing affordability, availability, accessibility via factor analysis to evaluate the association between each score key indicators of guideline-adherent care. Design, Setting, Participants This retrospective cohort study used data from patients OC diagnosed 2008 2015 Surveillance, Epidemiology, End Results (SEER) Medicare...