A5018450899- Plant-Microbe Interactions and Immunity
- Bioinformatics and Genomic Networks
- Plant Pathogenic Bacteria Studies
- Plant Parasitism and Resistance
- Plant Virus Research Studies
- Plant Molecular Biology Research
- Plant Gene Expression Analysis
- Photosynthetic Processes and Mechanisms
- Hidradenitis Suppurativa and Treatments
- Microbial Community Ecology and Physiology
- Plant Reproductive Biology
- Colorectal and Anal Carcinomas
- Plant tissue culture and regeneration
- Gut microbiota and health
- Plant Disease Resistance and Genetics
- Fungal and yeast genetics research
- Plant responses to water stress
- Legume Nitrogen Fixing Symbiosis
- Research in Cotton Cultivation
- Computational Drug Discovery Methods
- Inflammasome and immune disorders
- Plant Stress Responses and Tolerance
- Plant and Fungal Interactions Research
- Plant responses to elevated CO2
- Microbial Metabolic Engineering and Bioproduction
Clemson University
2024-2025
University of Alabama at Birmingham
2015-2024
Shenzhen University
2022
University of Alabama
2022
University of the Punjab
2021
University of North Carolina at Chapel Hill
2007-2016
Howard Hughes Medical Institute
2014
Max Planck Institute for Plant Breeding Research
2008
Max Planck Society
2007
An analysis of protein-protein interactions in Arabidopsis identifies the plant interactome.
Closely related pathogens may differ dramatically in host range, but the molecular, genetic, and evolutionary basis for these differences remains unclear. In many Gram- negative bacteria, including phytopathogen Pseudomonas syringae, type III effectors (TTEs) are essential pathogenicity, instrumental structuring exhibit wide diversity between strains. To capture dynamic nature of virulence gene repertoires across P. we screened 11 diverse strains novel TTE families coupled this nearly...
Endoplasmic reticulum (ER)-mediated protein secretion and quality control have been shown to play an important role in immune responses both animals plants. In mammals, the ER membrane-located IRE1 kinase/endoribonuclease, a key regulator of unfolded response (UPR), is required for plasma cell development accommodate massive immunoglobulins. Plant cells can secrete so-called pathogenesis-related (PR) proteins with antimicrobial activities upon pathogen challenge. However, whether plays any...
In all organisms, major biological processes are controlled by complex protein-protein interactions networks (interactomes), yet their structural complexity presents analytical challenges. Here, we integrate a compendium of over 4300 phenotypes with Arabidopsis interactome (AI-1
Cytokinin is a phytohormone that well known for its roles in numerous plant growth and developmental processes, yet it has also been linked to abiotic stress response less defined manner. Arabidopsis (Arabidopsis thaliana) Response Factor 6 (CRF6) cytokinin-responsive AP2/ERF-family transcription factor that, through the cytokinin signaling pathway, plays key role inhibition of dark-induced senescence. CRF6 expression induced by oxidative stress, here we show novel function relation identify...
Rising intense heat waves combined with lower precipitations are the new norms of current global scenarios. These altered climatic conditions negatively impact soybean yield potential and quality. Ten cultivars were subjected to four different growing conditions: control, drought, heat, drought understand physiological, yield, molecular changes. Stomatal conductance was reduced by 62% 10% under respectively. This reduction further exacerbated 93% when exposed stress. The highest canopy...
Abstract Cotton leaf curl disease (CLCuD), caused by cotton viruses (CLCuVs), is among the most devastating diseases in cotton. While widely cultivated species Gossypium hirsutum generally susceptible, diploid G. arboreum a natural source for resistance against CLCuD. However, influence of CLCuD on transcriptome and interaction with remains to be elucidated. Here we have used an RNA-Seq based study analyze differential gene expression under infestation. plants were infested graft inoculation...
Significance Pseudomonas syringae is a Gram-negative bacterium that uses type III secretion system to inject effector (T3E) proteins into the host cause disease in plants. Multiple P . T3Es promote virulence by targeting immune signaling pathways using diverse biochemical mechanisms. We provide evidence for molecular function of T3E HopAF1. demonstrate C-terminal region HopAF1 has structural homology deamidases. an enzyme important production gaseous hormone ethylene target and show targets...
COVID-19 (coronavirus disease 2019) is a respiratory illness caused by severe acute syndrome coronavirus 2 (SARS-CoV-2). Although the pathophysiology of this virus complex and largely unknown, we employed network-biology-fueled approach integrated transcriptome data pertaining to lung epithelial cells with human interactome generate Calu-3-specific human-SARS-CoV-2 (CSI). Topological clustering pathway enrichment analysis show that SARS-CoV-2 targets central nodes host-viral network, which...
Biological networks are often large and complex, making it difficult to accurately identify the most important nodes. Node prioritization algorithms used influential nodes in a biological network by considering their relationships with other These can help us understand functioning of role individual We developed CentralityCosDist, an algorithm that ranks based on combination centrality measures seed applied this four protein-protein interactions co-expression patterns Arabidopsis thaliana...
The regulation of gene expression in plant responses to drought has been thoroughly investigated previous studies. Despite this, a detailed understanding the cell type-specific regulatory mechanisms, encompassing multi-layered biological processes, is lacking. In this study, we report use single-nucleus multiomic analysis Arabidopsis seedlings response stress. Our single-nuclei RNA (snRNA) delineated 14 distinct clusters representing major root and shoot types discovered new markers....
WRKY transcription factors play a key role in modulating the plant defense transcriptome. Here we show that Arabidopsis mutant wrky27-1, which lacks functional WRKY27 factor, showed delayed symptom development response to bacterial wilt pathogen Ralstonia solanacearum. Additionally, wrky27-1 plants did not express PR marker genes upon infection, as also observed resistant Nd-1 plants. Spatial expression of correlated well with route infection and propagation planta. Complementation...
Biotrophic phytopathogens are typically limited to their adapted host range. In recent decades, investigations have teased apart the general molecular basis of intraspecific variation for innate immunity plants, involving receptor proteins that enable perception pathogen-associated patterns or avirulence elicitors from pathogen as triggers defense induction. However, consensus concerning evolutionary and factors alter range across closely related phytopathogen isolates has been more elusive....
Summary Cultivated cotton ( Gossypium hirsutum ) is the most important fibre crop in world. Cotton leaf curl disease CLC uD) major limiting factor and a threat to textile industry India Pakistan. All local cultivars exhibit moderate no resistance against uD. In this study, we evaluated an exotic accession Mac7 as source uD by challenging it with viruliferous whiteflies performing qPCR evaluate presence/absence relative titre of uD‐associated geminiviruses/betasatellites. The results...