A5018237503- Neurotransmitter Receptor Influence on Behavior
- Pain Mechanisms and Treatments
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Neuroscience of respiration and sleep
- Receptor Mechanisms and Signaling
- Substance Abuse Treatment and Outcomes
- Biochemical effects in animals
- Neural dynamics and brain function
- Behavioral Health and Interventions
- Neuropeptides and Animal Physiology
- Alkaloids: synthesis and pharmacology
- Pharmacological Receptor Mechanisms and Effects
- Connexins and lens biology
Washington University in St. Louis
2019-2024
Vanderbilt University
2022-2024
The hippocampus is pivotal in integrating emotional processing, learning, memory, and reward-related behaviors. dorsal (dHPC) particularly crucial for episodic, spatial, associative has been shown to be necessary context- cue-associated reward nucleus accumbens (NAc), a central structure the mesolimbic pathway, integrates salience of aversive rewarding stimuli. Despite extensive research on dHPC→NAc direct projections, their sufficiency driving reinforcement behavior remains determined. Our...
In this work, we studied a series of carfentanyl amide-based opioid derivatives targeting the mu receptor (μOR) and delta (δOR) heteromer as credible novel target in pain management therapy. We identified lead compound named MP135 that exhibits high G-protein activity at μ–δ heteromers compared to homomeric δOR or μOR low β-arrestin2 recruitment all three. Furthermore, distinct signaling profile, previously agonist heteromers, CYM51010. Pharmacological characterization supports utility...
Abstract Opioid withdrawal is a liability of chronic opioid use and misuse, impacting people who prescription or illicit opioids. Hyperactive autonomic output underlies many the aversive symptoms that make it difficult to discontinue use. The locus coeruleus (LC) an important centre within brain with poorly defined role in withdrawal. We show here pannexin-1 (Panx1) channels expressed on microglia critically modulate LC activity during Within LC, we found spinally projecting tyrosine...
Understanding sex differences in disease prevalence is critical to public health, particularly the context of alcohol use disorder (AUD). The goal this study was understand ethanol drinking behavior and define precise conditions under which emerge. Consistent with prior work, C57BL/6J females drank more than males continuous access two-bottle choice conditions. However, using self-administration - where an operant response results sipper for a fixed time period we found no rates or...
<b>Abstract ID 99086</b> <b>Poster Board 130</b> The nucleus accumbens (NAc) is a key site of alcohol-induced dysregulation; however, contextualizing what these changes mean for behavioral control requires deep understanding the information encoded within cell-type specific activity signatures in relation to behavior. major output neurons NAc are medium spiny (MSNs), which segregated based on expression D1 or D2 dopamine receptors. These cells make up 95% this population and nearly...