A5038860051- Trace Elements in Health
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Memory and Neural Mechanisms
- Alzheimer's disease research and treatments
- Biochemical effects in animals
- RNA regulation and disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Connexins and lens biology
- Cell Image Analysis Techniques
- Child and Adolescent Psychosocial and Emotional Development
- Nerve injury and regeneration
- Olfactory and Sensory Function Studies
- Neuroendocrine regulation and behavior
- Nicotinic Acetylcholine Receptors Study
- Heavy Metal Exposure and Toxicity
- Neurogenesis and neuroplasticity mechanisms
- Maternal Mental Health During Pregnancy and Postpartum
- Pharmacological Effects and Toxicity Studies
- Pharmacological Effects of Medicinal Plants
- Traumatic Brain Injury Research
- Craniofacial Disorders and Treatments
- Anesthesia and Sedative Agents
- Analytical Methods in Pharmaceuticals
- Cleft Lip and Palate Research
University of Calgary
2012-2025
University of Lethbridge
2020-2023
Allen Institute for Brain Science
2019
Vanderbilt University
1987
Abstract Disinhibition during early stages of Alzheimer's disease is postulated to cause network dysfunction and hyperexcitability leading cognitive deficits. However, the underlying molecular mechanism remains unknown. Here we show that, in mouse lines carrying disease-related mutations, a loss neuronal membrane potassium-chloride cotransporter KCC2, responsible for maintaining robustness GABAA-mediated inhibition, occurs pre-symptomatically hippocampus prefrontal cortex. KCC2...
Hippocampal CA1 neurons respond to sensory stimuli during enforced immobility, movement, and their transitions in a new conveyor belt task. Head-fixed mice were exposed light flashes or air streams while at rest, spontaneously moving, running fixed distance. Two-photon calcium imaging of revealed that 62% 3341 imaged cells active one more 20 sensorimotor events. Of these cells, 17% for any given event, with higher proportion locomotion. The study found two types cells: Conjunctive across...
Abstract Opioid withdrawal is a liability of chronic opioid use and misuse, impacting people who prescription or illicit opioids. Hyperactive autonomic output underlies many the aversive symptoms that make it difficult to discontinue use. The locus coeruleus (LC) an important centre within brain with poorly defined role in withdrawal. We show here pannexin-1 (Panx1) channels expressed on microglia critically modulate LC activity during Within LC, we found spinally projecting tyrosine...
Chronic stress can have deleterious effects on mental health, increasing the risk of developing depression or anxiety. But not all individuals are equally affected by stress; some susceptible while others more resilient. Understanding mechanisms that lead to these differing outcomes has been a focus considerable research. One unexplored mechanism is vesicular zinc - released neurons as neuromodulator. We examined how chronic stress, induced repeated social defeat, affects mice lack due...
Depression is a leading cause of disability worldwide, in part because the available treatments are inadequate and do not work for many people. The neurobiology depression, mechanism action common antidepressant drugs such as selective serotonin reuptake inhibitors (SSRIs), well understood. One thought to underlie effects these upregulation adult hippocampal neurogenesis. Evidence indicates that vesicular zinc required modulation neurogenesis, at least under some circumstances. Vesicular...
Damage to the hippocampus produces profound retrograde amnesia, but odour and object discrimination memories can be spared in direction. Prior lesion studies testing amnesia for object/odour discriminations are problematic due sparing of large parts hippocampus, which may support memory recall, and/or presence uncontrolled, distinctive odours that discrimination. To address these issues, we used a simple test assess male rats. Two visually distinct objects, paired with cues, were presented....
Abstract This study investigated the dynamics of recruitment cells in CA1 region hippocampus response to sensory stimuli presented during immobility, movement, and their transitions. Two-photon calcium imaging somal activity neuron populations was done head fixed mice. Sensory stimuli, either a light flash or an air stream, were delivered mice when at rest, moving spontaneously, while they induced run distance on conveyor belt. Overall, 99% 2083 identified (from 5 mice) active across one...
ABSTRACT In the central nervous system, certain neurons store zinc within synaptic vesicles of their axon terminals. This vesicular can then be released in an activity-dependent fashion as intercellular signal. The functions are not entirely understood, but evidence suggests that it is important for some forms experience-dependent plasticity brain. ability to and release dependent on expression transporter, ZnT3. Here, we examined neuronal morphology mice lack Brains were collected from...
ABSTRACT Depression is a leading cause of disability worldwide, in part because the available treatments are inadequate and do not work for many people. The neurobiology depression, mechanism action common antidepressant drugs such as selective serotonin reuptake inhibitors (SSRIs), well understood. One thought to underlie effects these upregulation adult hippocampal neurogenesis. Evidence indicates that vesicular zinc required modulation neurogenesis, at least under some circumstances....