A5002984390- Craniofacial Disorders and Treatments
- Morphological variations and asymmetry
- Connective tissue disorders research
- Cleft Lip and Palate Research
- dental development and anomalies
- Genetic Mapping and Diversity in Plants and Animals
- Bone and Dental Protein Studies
- Hedgehog Signaling Pathway Studies
- Genetic and phenotypic traits in livestock
- Developmental Biology and Gene Regulation
- Semiconductor Lasers and Optical Devices
- Axon Guidance and Neuronal Signaling
- Pleistocene-Era Hominins and Archaeology
- Fibroblast Growth Factor Research
- Wildlife Ecology and Conservation
- Primate Behavior and Ecology
- Forensic Anthropology and Bioarchaeology Studies
- Photonic and Optical Devices
- 3D Shape Modeling and Analysis
- Cell Image Analysis Techniques
- Bone Metabolism and Diseases
- Medical and Biological Sciences
- Advanced Fiber Laser Technologies
- Medical Image Segmentation Techniques
- Genetic diversity and population structure
Stony Brook University
2017-2025
Kyoto University
2021
Alberta Children's Hospital
2014-2019
University of Calgary
2014-2019
Pennsylvania State University
2010-2019
Alberta Bone and Joint Health Institute
2015-2018
National Microelectronics Applications Centre (Ireland)
2003-2005
Tyndall National Institute
2005
A full ring ultrasonic array-based photoacoustic tomography system was recently developed for small animal brain imaging. The 512-element array is cylindrically focused in the elevational direction, and can acquire a two-dimensional (2D) image 1.6 s. In this letter, we demonstrate three-dimensional (3D) imaging capability of system. novel 3D reconstruction algorithm based on focal-line concept. Compared to images acquired simply by stacking series 2D images, method renders with much less...
Abstract Background Apert syndrome is characterized by craniosynostosis and limb abnormalities primarily caused FGFR2 +/P253R +/S252W mutations. The former mutation present in approximately one third whereas the latter two-thirds of patients with this condition. We previously reported an inbred transgenic mouse model Fgfr2 on C57BL/6J background for syndrome. Here we a Fgfr2+/P253R mutation. Results generated +/ P253R mice same C56BL/6J genetic analyzed their skeletal abnormalities. 3D...
Abstract Apert syndrome is a congenital disorder caused mainly by two neighboring mutations on fibroblast growth factor receptor 2 (FGFR2). Premature closure of the coronal suture commonly considered identifying and primary defect triggering or preceding additional cranial malformations phenotype. Here we use transgenic mouse models syndrome, Fgfr2 +/ S252W P253R , to explore variation in phenotypes newborn (P0) mice. Results show that facial skeleton most affected region cranium. Coronal...
Beare-Stevenson cutis gyrata syndrome (BSS) is a human genetic disorder characterized by skin and skull abnormalities. BSS caused mutations in the FGF receptor 2 (FGFR2), but molecular mechanisms that induce abnormalities are unclear. We developed mouse model of harboring FGFR2 Y394C mutation identified p38 MAPK as an important signaling pathway mediating these Fgfr2+/Y394C mice exhibited epidermal hyperplasia premature closure cranial sutures (craniosynostosis) due to abnormal cell...
Morphometric analysis of anatomical landmarks allows researchers to identify specific morphological differences between natural populations or experimental groups, but manually identifying is time-consuming. We compare and automatically generated adult mouse skull subsequent morphometric analyses elucidate how switching from manual automated landmarking will impact results for large (Mus musculus) samples (n = 1205) that represent a wide range 'normal' phenotypic variation (62 genotypes)....
Anterior-posterior (A-P) elongation of the palate is a critical aspect integrated midfacial morphogenesis. Reciprocal epithelial-mesenchymal interactions drive secondary that coupled to periodic formation signaling centers within rugae growth zone (RGZ). However, relationship between RGZ-driven morphogenetic processes, differentiative dynamics underlying palatal bone mesenchymal precursors, and segmental organization upper jaw has remained enigmatic. A detailed ontogenetic study these...
Abstract Background Urban forests play a significant role in mitigating the adverse effects of climate change by absorption greenhouse gases and carbon sequestration. However, soil compaction caused anthropogenic activities can be major detriment to urban forest health. Method Two potential nature-based decompaction solutions (addition earthworms, nitrogen-fixing white clover cropping) were evaluated combination with existing systems (vertical mulching, woodchip surface layer). Effects on...
Abstract Apert syndrome (AS) is one of at least nine disorders considered members the fibroblast growth factor receptor (FGFR) ‐1, ‐2, and ‐3–related craniosynostosis syndromes. Nearly 100% individuals diagnosed with AS carry two neighboring mutations on Fgfr2. The cranial phenotype associated these includes coronal suture synostosis, either unilateral (unicoronal synostosis) or bilateral (bicoronal synostosis). Brain dysmorphology thought to be secondary vault base alterations, but...
Morphological divergence among related species involves changes to developmental processes. When such variation arises in development has garnered considerable theoretical interest relating the broader issue of how may constrain evolutionary change. The hourglass model holds that while early events be highly evolvable, there is a phylotypic stage when key are conserved. Thus, should tend arise after reduced evolvability and, consequently, species. We test this prediction by comparing...
Abstract Using eight inbred founder strains of the mouse Collaborative Cross ( CC ) project and their reciprocal F1 hybrids, we quantified variation in craniofacial morphology across strains, explored genetic contributions to that distinguish tested whether specific or summary measures shape display stronger additive contributions. This study thus provides critical information about phenotypic diversity among this diversity, which is relevant understanding basis standard laboratory natural...
Peters plus syndrome (MIM #261540 PTRPLS), characterized by defects in eye development, prominent forehead, hypertelorism, short stature and brachydactyly, is caused mutations the β3-glucosyltransferase (B3GLCT) gene. Protein O-fucosyltransferase 2 (POFUT2) B3GLCT work sequentially to add an O-linked glucose β1-3fucose disaccharide properly folded thrombospondin type 1 repeats (TSRs). Forty-nine proteins are predicted be modified POFUT2, nearly half members of ADAMTS superfamily. Previous...
Abstract Experimental studies have demonstrated that nutritional changes during development can result in phenotypic to mammalian cheek teeth. This developmental plasticity of tooth morphology is an example plasticity. Because occurs through complex interactions between manifold processes, there are many potential mechanisms which contribute a tooth’s norm reaction. Determining the identity those and relative importance each them one main challenges understanding Quantitative proteomics...
Morphological integration, or the tendency for covariation, is commonly seen in complex traits such as human face. The effects of growth on shape, allometry, represent a ubiquitous but poorly understood axis integration. We address question to what extent age and measures size converge single pattern allometry facial shape.Our study based two large cross-sectional cohorts children, one from Tanzania other United States (N = 7,173). employ 3D imaging geometric morphometrics relate shape...
Abstract Inbred genetic background significantly influences the expression of phenotypes associated with known perturbations and can underlie variation in disease severity between individuals same mutation. However, effect epistatic interactions on development complex traits, such as craniofacial morphology, is poorly understood. Here, we investigated three inbred backgrounds (129X1/SvJ, C57BL/6J, FVB/NJ) dysmorphology mice (Mus musculus) loss function members Sprouty family growth factor...
The biology of how faces are built and come to differ from one another is complex. Discovering normal variants that contribute differences in facial morphology key untangling this complexity, with important implications for medicine evolutionary biology. This study maps quantitative trait loci (QTL) skeletal shape using Diversity Outbred (DO) mice. DO a randomly outcrossed population high heterozygosity captures the allelic diversity eight inbred mouse lines three subspecies. uses sample...
Morphometric quantification of subtle craniofacial variation in studies experimentally modified embryonic mice has proved valuable determining the effects developmental perturbations on morphogenesis. The direct comparison landmark coordinate data from embryos many different mouse strains and models can advance our understanding bases for variation. We propose a standard set surface landmarks, use with day (E) 10.5-12.5 mice, to serve as foundation this type compilation analysis. quantify...
Background : Quantifying multiple phenotypic aspects of individual craniofacial bones across early osteogenesis illustrates differences in typical bone growth and maturation provides a basis for understanding the localized overall influence mutations associated with disease. We quantify pattern during determine how this is modified Fgfr2 +/P253R Apert syndrome mice. Results: Early relative density increase are noted between intramembranous endochondral bones, normally maturing more quickly...