A5007635476- Sepsis Diagnosis and Treatment
- Neonatal and Maternal Infections
- Viral gastroenteritis research and epidemiology
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Emergency and Acute Care Studies
- Streptococcal Infections and Treatments
- Immune Response and Inflammation
- Animal Virus Infections Studies
- Hemodynamic Monitoring and Therapy
- Thermal Regulation in Medicine
- Inflammation biomarkers and pathways
- Trauma and Emergency Care Studies
- Child and Adolescent Health
- Respiratory Support and Mechanisms
- Hepatitis Viruses Studies and Epidemiology
- Food Security and Health in Diverse Populations
- Nutritional Studies and Diet
- Health Systems, Economic Evaluations, Quality of Life
- Obesity, Physical Activity, Diet
- Complement system in diseases
- Nutrition, Health and Food Behavior
- Viral Infections and Vectors
- Legal Studies and Reforms
- Clostridium difficile and Clostridium perfringens research
Riga Stradiņš University
2010-2023
National and Kapodistrian University of Athens
2023
Imperial College London
2023
Children's Clinical University Hospital
1998-2016
Latvian Maritime Academy
2000
ABSTRACT At a children’s hospital in Riga, Latvia, isolates identified as Salmonella typhimurium were found to be resistant expanded-spectrum cephalosporins. Two of the strains analyzed for mechanism cephalosporin resistance. Isoelectric focusing revealed common β-lactamase with pI 8.8. In addition, one produced 7.6 β-lactamase. A transconjugant producing only enzyme was susceptible cephalosporins; therefore, this most likely SHV-1. Transformants 8.8 cefotaxime and aztreonam but or...
In accordance with the 1st International pediatric sepsis consensus conference, where was defined as SIRS associated suspected or proven infection, we have identified need to assess prevalence of and in children abnormal temperatures hospitalized The Children's Clinical University Hospital Latvia.A descriptive prospective point study (using two time periods, each 24 h, randomly chosen) conducted on all (n = 943) treated hospital. All - fever hypothermia 92) were included study....
Even though sepsis is one of the common causes children morbidity and mortality, specific inflammatory markers for identifying are less studied in children. The main aim this study was to compare levels high-mobility group box-1 protein (HMGB1), Lipopolysaccharide-binding (LBP), Interleukin-6 (IL-6) C-reactive (CRP) between infected without systemic response syndrome (SIRS) with severe sepsis. second examine HMGB1, LBP, IL6 CRP as bacteraemia. Totally, 140 suspected or proven infections...
Objectives: Pediatric mortality in Latvia remains one of the highest among Europe. The purpose this study was to assess quality pediatric acute care and readiness determine their association with patient outcomes using a registry. Design: This prospective cohort study. measured weighted score based on 100-point scale. processes were situ simulations generate composite score. Clinical outcome data—including PICU hospital length stay as well 6-month mortality—were collected from Intensive Care...
Abstract Sepsis is among the leading causes of critical illness worldwide. It includes physiologic, pathologic, and biochemical abnormalities, induced by infection. Novel methods for recognizing a dysregulated inflammatory response predicting associated mortality must be developed. Our aim was to investigate biomarkers that characterize pro-inflammatory anti-inflammatory in patients with fever comparing predictive validity sepsis. 165 were enrolled this study, 55 them had sepsis according...
Children constitute 6-10% of all patients attending the emergency department (ED) by medical services (EMS). However, discordant EMS use in children occurs 37-61% with fever as an important risk factor. We aimed to describe utilisation among febrile European EDs. This study is part observational multicentre assessing management and outcome up 18 years (MOFICHE) twelve EDs eight countries. Discordant was defined absence markers urgency including intermediate/high triage urgency, advanced...
Background: Detection of small proportion serious bacterial infections (SBI) with a potentially life threating course in large group children fever admitted to emergency department (ED) is still complicated. Measurement immature granulocytes (IG) percentage may be used as marker infections. The aim the study was evaluate whether IG useful additional predictive SBI. Methods: This included 258 febrile that were ED. Clinical follow-up, microbiological and radiological tests reference standards...
Rotavirus is the leading cause of severe diarrhea in young children and infants worldwide, representing a heavy public health burden. Limited information available regarding impact rotavirus gastroenteritis on quality life affected their families. The objectives study were to estimate infection health-related (HRQL), assess social emotional effects families children. This enrolled all (n = 527) RotaStrip®-positive (with further PCR detection) cases (0–18 years age) hospitalized from April...
Sepsis caused by infection remains a major cause of mortality and morbidity among children.Several inflammatory markers have failed to meet the requirements for early diagnosis sepsis.We saw potential value measuring total leukocyte count C reactive protein (CRP), procalcitonin (PCT) interleukin (IL) 6 in patients with SIRS identifying sepsis.Children (n = 52) were included prospective study.Changes levels their inter-correlations evaluated sepsis at different time points.Sepsis was...
Background and objectives: In children, acute infection is the most common cause of visits to emergency department. Although them are self-limiting, mortality due severe bacterial infections (SBI) in developed countries still high. When risk serious too high ignore, yet low justify admission hospital observation, clinicians try improve diagnostic accuracy by performing various laboratory tests. The aim study was investigate whether an early inflammatory cytokine chemokine panel can add...
Abstract In developed and developing countries, most cases of acute gastroenteritis in children are caused by viruses, rotaviruses known as the leading cause. The aim our study was to estimate main circulating serotypes rotavirus before introduction routine immunisation Latvia, search for their possible correlation with clinical symptoms genotypes. A cross-sectional carried out among who had been hospitalised Children’s Clinical University Hospital from April 2013 December 2015. Genotyping...
Background and objectives: In children, acute infection is the most common cause of visits in primary care or emergency department. 2002, criteria for diagnostics pediatric sepsis were published, then revised 2016 as "life-threatening organ dysfunction due to a dysregulated host response infection". pathophysiology endothelial plays very important role. Deficient proteolysis von Willebrand factor, reduced ADAMTS-13 activity, results disseminated platelet-rich thrombi microcirculation....
Aims: The aim of this research was to investigate the genetically determined predisposition develop SIRS and sepsis by analyzing human leukocyte antigen HLA class II genes. Study Design: children defined criteria for Critical Care Medicine Consensus Conference were included into study in a prospective manner. Place Duration Study: Riga Stradiņs University Laboratory Clinical Immunology Immunogenetic, Department Pediatrics, Rīga University, Children’s Hospital, Latvia, between January 2008...
In 2010 in Latvia, invasive pneumococcal disease (IPD) became a cause for concern and vaccination of infants with four doses 7-valent conjugate vaccine (PCV7) commenced. 2012, 10-valent (PCV10) (three at 2, 4, 12-15 month age) was introduced. We described incidence serotype distribution IPD Latvia investigated serotypes associated death from based on surveillance data. Adult against infection is not included the national immunization program. Laboratory confirmed cases are passively notified...
Background: Detection of small proportion serious bacterial infections (SBI) with potentially life threating course in a large group children fever admitted to emergency department (ED) is still complicated. Measurement immature granulocytes (IG) percentage may be used as marker infections. The aim the study was evaluate whether IG useful additional predictive SBI. Methods: This included 258 febrile ED. Clinical follow-up, microbiological and radiological tests were reference standards for...
Background: The aim of the study was to evaluate effect systemic inflammatory response syndrome (SIRS) on serum high-molecular-weight adiponectin (HMWA) levels. Method: Twelve children with SIRS were enrolled in this at intensive care unit (ICU). age and sex matched healthy subjects selected as controls. Serum HMWA, interleukin-6 (IL-6), C-reactive protein (CRP), procalcitonin (PCT) levels determined after 2 hours 24 hours, day discharge which average 9.4 days ICU admission. Results:...
Clostridium difficile Associated Disease Clinical and Molecular Data Introduction. A balanced microflora of the gastrointestinal tract plays a significant role in protection an organism. Dramatic changes may take place composition normal during antibacterial therapy, because part sensitive microorganisms die detrimental to organism proliferates there causing disorders (7). C. is important agent disorders. It induce manifestations ranging from asymptomatic colonization severe diarrhea,...
<h3>Background</h3> Rotavirus is the leading cause of acute gastroenteritis in children worldwide. A quality life (QOL) study was conducted as a part larger “Clinical peculiarities rotaviral infection, molecular epidemiology and health associated QOL for hospitalised their family members”, financially supported by Riga Stradins University. <h3>Aim</h3> To investigate impact (RVGE) on affected parents. <h3>Methods</h3> Data with burden RVGE were extracted from questionnaires completed parents...
<h3>Background</h3> The incidence of rotaviral gastroenteritis (RVGE) has significantly increased in last 10 years Latvia. <h3>Aims</h3> To assess the impact family on RVGE. <h3>Methods</h3> study enrolled children (1–23 month age) hospitalised University Children’s Hospital within time period June 2013 – February 2014 if child rotavirus positive stool sample. clinical severity illness was rated using a scoring system. Parents were interviewed and examination done. <h3>Results</h3> Mean age...
Abstract Introduction. Pneumonia is a common childhood lower respiratory tract infection, which accounts for large number of hospitalization and death among children; its diagnosis based mainly on clinical signs. Aim the study was to measure inflammatory cytokine panels in children with pneumonia, their correlation clinically used markers. Materials methods. We included 20 patients, hospitalized Children’s Clinical University hospital, systemic response syndrome (SIRS) radiologically...
Diagnostic Markers for Early Sepsis Diagnosis in Children With Systemic Inflammatory Response Syndrome caused by infection remains a major cause of mortality among children. One the main reasons high sepsis rates is inability to obtain early diagnosis. Sensitive and specific biomarkers are greatly needed rapid diagnosis sepsis. The aim study was investigate ability high-mobility group box-1 protein (HMGB1), lipopolysaccharide-binding (LBP), Interleukin-6 (IL-6), procalcitonin (PCT) C...