A5089259979- Fibromyalgia and Chronic Fatigue Syndrome Research
- Gut microbiota and health
- Legionella and Acanthamoeba research
- Vector-borne infectious diseases
- Nonmelanoma Skin Cancer Studies
- Water Treatment and Disinfection
- Viral Infections and Vectors
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Liver Disease Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Antibiotics Pharmacokinetics and Efficacy
- Cutaneous Melanoma Detection and Management
- Vector-Borne Animal Diseases
- Hepatitis C virus research
- Parvovirus B19 Infection Studies
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Genetic Neurodegenerative Diseases
- Musculoskeletal pain and rehabilitation
- Sepsis Diagnosis and Treatment
- Cancer and Skin Lesions
- Mosquito-borne diseases and control
- Bone and Joint Diseases
- Amoebic Infections and Treatments
Riga Stradiņš University
2016-2025
Institute of Food Safety, Animal Health and Environment “BIOR”
2016-2024
Riga East University Hospital
2017-2021
Research Centre for Medical Genetics
2014
Children's Clinical University Hospital
2014
Designed by a group of ME/CFS researchers and health professionals, the European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE) has received funding from Cooperation in Science Technology (COST)-COST action 15111-from 2016 to 2020. The main goal Cost Action was assess existing knowledge experience care delivery for people with (ME/CFS) countries, enhance coordinated research provision this field. We report our findings make recommendations clinical diagnosis,...
Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multifactorial disease with an unexplained aetiology in which viral infections are possible trigger factors. The aim of this study was to determine the involvement human herpesvirus (HHV)-6A/B, HHV-7, and parvovirus B19 (B19V) etiopathogenesis ME/CFS. Methods 200 patients clinically diagnosed ME/CFS 150 apparently healthy individuals were enrolled study. Single-round, nested, quantitative real-time...
Abstract Background Tobacco smoking and alcohol consumption are leading causes of the global burden disease major contributors to premature mortality. The risk factors like cigarette smoking, diet preferences have been identified responsible for ulcerative colitis patient’s microbiome alteration. Methods In 12-month time (June 2021 June 2021) 79 (UC) outpatients from Riga East Clinical University Hospital 78 healthy controls were included in a Cross-sectional study. All patients divided into...
Background and purpose: To report a 37‐year observational experience in Latvia relating the incidence of human tick‐borne encephalitis (TBE) its clinical manifestations, to field abundance ticks. Methods: Tick was measured by standard flagging techniques. Incidence disease derived from Public Health reporting data. Clinical follow‐up data were determined hospital cohorts 1973 2009. Results: Two TBE peaks mid‐1970s 1990s correlated with increased Increased 1970s associated higher both Ixodes...
Frequency of active human herpesvirus-6, -7 (HHV-6, HHV-7) and parvovirus B19 (B19) infection/coinfection its association with clinical course ME/CFS was evaluated. 108 patients 90 practically healthy persons were enrolled in the study. Viral genomic sequences detected by PCR, virus-specific antibodies cytokine levels-by ELISA, HHV-6 variants-by restriction analysis. Active viral infection including concurrent found 64.8% (70/108) 13.3% (12/90) persons. Increase peripheral blood leukocyte...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease that mainly diagnosed based on its clinical symptoms. Biomarkers could facilitate the diagnosis of ME/CFS are not yet available; therefore, reliable and clinically useful indicators high importance. The aim this work was to analyze association between course severity, presence HHV-6A/B infection markers, plasma levels autoantibodies against adrenergic muscarinic acetylcholine receptors. A total 134 patients with...
Background The incidence of tick-borne encephalitis (TBE) varies significantly over time. To better understand the annual all TBE cases in Latvia we investigated disease burden country from 1973–2016 using several available sources and case definitions. Methods We identified an electronic database (maintained by Centre for Disease Prevention Control [CDPC]) use ICD-10 diagnosis codes (A84; A84.0; A84.1; A84.8; A84.9). In addition, previously unreported were found review diagnoses according...
Trichinella spp. are zoonotic parasites transmitted to humans by the consumption of raw or insufficiently cooked meat different animal species. The most common source infection for is from pigs and wild boar (Sus scrofa). aim present work was evaluate incidence infections in hunted Latvia over a 38 year interval (1976 2013). A total 120,609 boars were individually tested trichinoscopy and, case negativity, artificial digestion 25 g muscles, 1976–2005 period, 25–50 muscles 2006–2013 period....
Abstract Background There has been much interest in the possible benefits of microbiome-modulating interventions, such as probiotics, prebiotics, antibiotics ulcerative colitis. Microbiota plays an important role host health and is perturbed by several factors including diseases like coronavirus disease 2019 (COVID-19). Methods From June 2021 to 2022 79 colitis (UC) outpatients from Riga East Clinical University Hospital 78 healthy controls were included a Cross-sectional study. All patients...
Abstract Background Psychological and physical stress can worsen symptoms contribute to flare-ups in ulcerative colitis (UC) patients. The education level, occupation income level may affect patients during stressful periods such as COVID-19 outbreak. Methods In 12 months time (June 2021 June 2022) 79 outpatients from Riga East Clinical University Hospital 78 healthy controls were included a Cross-sectional study. All divided into groups according medically proven data about status...
Background and Objectives: The human gut microbiome is essential for the health of host affected by antibiotics coronavirus disease 2019 (COVID-19). recognized as a contributing factor in development ulcerative colitis. Specific vitamins probiotics have been demonstrated to positively influence enhancing prevalence expected beneficial microorganisms. Materials Methods: Forty-nine colitis (UC) outpatients from Riga East Clinical University Hospital were enrolled this cross-sectional study...
Background Streptococcus pneumoniae is a major cause of Invasive pneumococcal disease (IPD), including bacteremic pneumonia, septicemia, and meningitis. The introduction conjugate vaccines (PCVs) has significantly reduced the incidence IPD caused by vaccine-covered serotypes. However, serotype replacement antimicrobial resistance remain concerns. In Latvia, vaccination against was introduced into NIP in 2010 with PCV7, later transitioning to PCV10 2012 PCV15 2024. This study aims determine...
ME/CFS is a chronic, complex, multisystem disease that often limits the health and functioning of affected patients. Diagnosing patients with challenge, many different case definitions exist are used in clinical practice research. Even after diagnosis, medical treatment very challenging. Symptom relief coping may affect how live their quality life. There no consensus on which diagnostic criteria should be strategies can recommended for The purpose current project was to map landscape...
Background and Objectives:Legionella is one of the most important water-related pathogens. Inside water supply systems biofilms, Legionella interact with other bacteria free-living amoeba (FLA). Several amoebas may serve as hosts for in aquatic systems. This study aimed to investigate co-occurrence spp. FLA drinking Materials Methods: A total 268 samples were collected from apartment buildings, hotels, public buildings. Detection was performed accordance ISO 11731:2017 standard. Three...
Legionella is one of the most important waterborne pathogens that can lead to both outbreaks and sporadic cases. The majority travel-associated Legionnaires' disease (TALD) cases are contracted during hotel stays. aim this study was evaluate prevalence genetic diversity spp. in water supply systems Latvia. In total, 834 hot samples were collected from 80 hotels At least positive sample detected 47 out (58.8%). Overall, 235 (28.2%) positive. average temperature Latvian 49.8 °C. predominant L....
Background: Age and cumulative exposure to ultraviolet (UV) light are primary contributors skin cancer development. Regulatory proteins within the cell cycle essential for homeostasis of squamous epithelium. Methods: This study assessed expression immunohistochemical markers p53, p63, p16, Ki67, Cyclin D, Bcl-2, CD31 in keratinocyte intraepithelial neoplasia (actinic keratosis carcinoma situ) compared normal skin. The objective was distinguish disease-specific changes from those attributable...
Enhanced bleeding remains a serious problem after cardiac surgery, and fibrinolysis is often involved. We speculate that lower plasma concentrations of plasminogen activator inhibitor - 1 (PAI-1) preoperatively tissue activator/PAI-1 (t-PA/PAI-1) complex postoperatively might predispose for enhanced increased postoperative bleeding.Totally 88 adult patients (mean age 66 ± 10 years) scheduled were enrolled into prospective study. Blood samples collected pre-operatively, on admission to the...
Background and objectives: Colistin is used for the treatment of multidrug-resistant (MDR) Gram-negative bacteria infection in critically ill patients. It recommended to adjust dose cases renal impairment but not augmented clearance (ARC). The aim this study was determine colistin use pattern patients with different functional states. Materials andMethods: Adult admitted intensive care units single Latvian hospitals years 2015⁻2017 an MDR bacterial at least 72 h therapy were included study....
In Latvia and other endemic regions, a single tick bite has the potential to transmit both tick-borne encephalitis (TBE) Lyme borreliosis.To analyse clinical features differential diagnosis of combined infection with TBE borreliosis, in 51 patients serological evidence, whom 69% had bites.Biphasic fever suggestive occurred 55% patients. Meningitis 92%, painful radicular symptoms 39%. Muscle weakness 41%; 29% flaccid paralysis was compatible TBE. Only two presented bulbar palsy typical...