A5003071611- Parvovirus B19 Infection Studies
- Respiratory viral infections research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Tracheal and airway disorders
- Long-Term Effects of COVID-19
- Autoimmune and Inflammatory Disorders Research
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Dermatological and COVID-19 studies
- COVID-19 Clinical Research Studies
- Reconstructive Surgery and Microvascular Techniques
- Exercise and Physiological Responses
- Eosinophilic Disorders and Syndromes
- COVID-19 and healthcare impacts
- Prenatal Screening and Diagnostics
- Prostate Cancer Diagnosis and Treatment
- Viral Infections and Vectors
- Animal Virus Infections Studies
- Venous Thromboembolism Diagnosis and Management
- Immune Response and Inflammation
- Multiple Sclerosis Research Studies
- Pneumonia and Respiratory Infections
- Neuroinflammation and Neurodegeneration Mechanisms
- Hereditary Neurological Disorders
- Nutrition and Health in Aging
Riga Stradiņš University
2015-2025
Czech Academy of Sciences, Institute of Microbiology
2016-2021
Czech Academy of Sciences, Institute of Biotechnology
2020
Vilnius University
2020
Riga East University Hospital
2020
Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multifactorial disease with an unexplained aetiology in which viral infections are possible trigger factors. The aim of this study was to determine the involvement human herpesvirus (HHV)-6A/B, HHV-7, and parvovirus B19 (B19V) etiopathogenesis ME/CFS. Methods 200 patients clinically diagnosed ME/CFS 150 apparently healthy individuals were enrolled study. Single-round, nested, quantitative real-time...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease that mainly diagnosed based on its clinical symptoms. Biomarkers could facilitate the diagnosis of ME/CFS are not yet available; therefore, reliable and clinically useful indicators high importance. The aim this work was to analyze association between course severity, presence HHV-6A/B infection markers, plasma levels autoantibodies against adrenergic muscarinic acetylcholine receptors. A total 134 patients with...
Background and Objectives: Microvascular flap surgery is a widely used reconstructive technique for the repair of various defects. Biomarkers have become an essential tool monitoring viability, early detection complications, prediction surgical outcomes. Studies focusing on immunomodulatory cytokines in microvascular complications are lacking. We aimed to investigate predictive value postoperative changes transforming growth factor beta-1 (TGF-β1) complications. Materials Methods: This...
Three human protoparvoviruses, bufavirus (BuV), tusavirus (TuV) and cutavirus (CuV), have recently been discovered in diarrheal stool. BuV has associated with diarrhea CuV cutaneous T-cell lymphoma, but there are hardly any data for TuV or stool respiratory samples. Hence, using qPCR IgG enzyme immunoassays, we analyzed 1072 stool, 316 445 serum plasma samples from 1098 patients without gastroenteritis (GE) respiratory-tract infections (RTI) Finland, Latvia Malawi. The overall CuV-DNA...
Human bocaviruses (HBoVs) 1–4 belong to the Parvoviridae family, and they infect respiratory or gastrointestinal tracts in children. We investigated prevalence of HBoV1–4 DNAs blood stool samples, IgG IgM plasma children presenting with acute gastroenteritis (AGE). In addition, we identified HBoV co-infections five most frequent pathogens. A total 83 paired samples were collected from aged years less. Infection markers HBoV1, 2, 3 (viral DNA and/or antibodies) detected 61 out (73.5%)...
: Microvascular flap surgery has become a routine option for defect correction. The role of von Willebrand factor antigen (VWF:Ag) in the pathophysiology complications is not fully understood. We aim to investigate predictive value VWF:Ag microvascular and explore relationship between chronic inflammation VWF:Ag.
Abstract Background Human bocavirus 1 is a commonly detected human parvovirus. Many studies have shown as pathogen in association with acute respiratory tract infections children. However, because persists the upper airways for extensive time periods after infection, definition and diagnostics of infection challenging. Until now, detection exclusively, high viral load samples, viremia been associated clinical picture illness. There are no showing messenger ribonucleic acid peripheral blood...
Human bocavirus (HBoV) is a causative agent of respiratory and gastrointestinal diseases worldwide. Four HBoV species (HBoV1-4) have been identified so far. Although previous report has documented the association with acute gastroenteritis (AGE) in Taiwan, their epidemiology, genetic diversity, phylogenetic relationships remain unclear. In this study, we focused on an investigation these unsolved issues, which will help to reveal molecular epidemiology phylogeny circulating HBoV2 Taiwan. A...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex multifactorial disease that causes increasing morbidity worldwide, and many individuals with ME/CFS symptoms remain undiagnosed due to the lack of diagnostic biomarkers. Its etiology still unknown, but evidence supports role herpesviruses (including HHV-6A HHV-6B) as potential triggers. Interestingly, infection by these viruses has been reported impact expression microRNAs (miRNAs), short non-coding RNA sequences which...
After primary exposure, the human parvovirus B19 (B19V) genome may remain in central nervous system (CNS), establishing a lifelong latency. The structural characteristics and functions of infected cells are essential for virus to complete its life cycle. Although B19V has been detected brain tissue by sequencing PCR products, little is known about vivo cell tropism pathogenic potential CNS. To detect investigate distribution target CNS, we studied autopsies elderly subjects using molecular...
Meningitis and meningoencephalitis are neurological inflammatory diseases, although routine diagnostics include testing of a wide range pathogens, still in many cases, no causative agent is detected. Human parvovirus B19 (B19V), human bocaviruses 1-4 (HBoV1-4), 4 (hPARV4) members the Parvoviridae family associated with clinical manifestations including disorders. The main aim this study was to determine whether parvoviruses infection markers present among patients...
Reliable serum biomarkers are of immense need for diagnostic purposes myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-a disabling and complex disease which diagnosis is mainly based on clinical symptoms. The aim this study was to evaluate a possible potential activin B by directly comparing 134 cases ME/CFS with 54 healthy controls. Analyses human level in plasma samples were performed using validated ELISA assay. results the show that levels did not differ statistically...
Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic condition with no identified diagnostic biomarkers to date. Its prevalence as high 0.89% according metastudies, quarter of patients bed- or home-bound, which presents serious public health challenge. Investigations into the inflammation–immunity axis encouraged by links outbreaks and disease waves. Recently, research our group revealed that antibodies beta2-adrenergic (anti-β2AdR) muscarinic...
Abstract Human bocavirus 1 (HBoV1) is a parvovirus recently found to be possible aetiologic agent of acute respiratory disease in children. We conducted the first clinical and molecular study on this virus Latvia (LV) Lithuania (LT). The aim was determine occurrence HBoV1 tract samples taken from hospitalised children with infections LV LT. In total 186 age one 50 months, who fulfilled criteria infection, including lower infections, or without fever, were included study. A nasopharyngeal...
Fibromyalgia (FM) is a chronic disorder characterized by widespread musculoskeletal pain often accompanied fatigue, sleep disturbances, memory issues, and mood disorders. The exact cause of FM remains unknown, diagnosis typically based on history persistent pain, as there are no objective biomarkers usable in this available. aim study was to identify measurable indicators specific with potential biomarkers. This included 17 individuals diagnosed 24 apparently healthy persons. Using real-time...
Forecasting the progression of disease in early inflammatory stage most prevalent type multiple sclerosis (MS), referred to as relapsing-remitting (RRMS), is essential for making prompt treatment modifications, aimed reduce clinical relapses and disability. In total, 58 patients with RRMS, having an Expanded Disability Status Scale (EDSS) score less than 4, were included this study. Baseline magnetic resonance imaging (MRI) was performed, brain spinal cord lesions evaluated. The disability...
Abstract Lower respiratory tract infection (LRTI) is the major cause of morbidity and mortality children in world. In addition to syncytial virus, influenza virus types A B, parainfluenza 1, 2 3, adenoviruses, several new viruses associated with LRTI were discovered 21 st century. These are metapneumovirus, coronaviruses NL63 HKU1, type four human bocavirus one (HBoV1). HBoV1 was 2005 considered as fourth most prevalent worldwide. However, high frequency co-infections detected together...
Abstract Since its discovery in 2005, human bocavirus 1 (HBoV1) has globally been one of the most common respiratory viruses. It is currently accepted that HBoV1 a pathogen, causing upper and lower tract infections (LRTIs) children. However, due to prolonged DNA shedding from airways subsequent high rate co-detections with other viruses, interpretation positive polymerase chain reaction results challenging. The aim this study was identify acute by presence HBoV1-specific IgM IgG measured...
Abstract Background: Meningitis and meningoencephalitis are neurological inflammatory diseases although routine diagnostics include testing of wide range pathogens, still in many cases no causative agent is detected. Human parvovirus B19 (B19V), human bocaviruses 1-4 (HBoV1-4) 4 (hPARV4) members Parvoviridae family associated with clinical manifestations including disorders. The main aim this study was to determine whether parvoviruses infection markers present among patients...
Abstract Background The risk of developing severe and even fatal coronavirus disease 2019 (COVID-19) increases with various factors such as advanced age chronic diseases, especially those treated immunosuppressive drugs. Viral ribonucleic acid (RNA) viral load detection in extra-pulmonary specimens have been proposed to indicate severity. Case presentation Here we describe a COVID-19 case an 83-year-old Caucasian male patient underlying comorbidities, including cardiovascular autoimmune...
Abstract The authors have withdrawn this preprint due to a need make corrections.