A5002794123- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Outbreaks Research
- Mosquito-borne diseases and control
- HIV Research and Treatment
- Animal Virus Infections Studies
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Antibiotic Resistance in Bacteria
- Bat Biology and Ecology Studies
- Vaccine Coverage and Hesitancy
- COVID-19 epidemiological studies
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Malaria Research and Control
- vaccines and immunoinformatics approaches
- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- Animal Disease Management and Epidemiology
- Bacterial Infections and Vaccines
- Reproductive tract infections research
- Hepatitis B Virus Studies
- Emergency and Acute Care Studies
- Virus-based gene therapy research
- Cervical Cancer and HPV Research
University of Nairobi
2016-2025
Kenya AIDS Vaccine Initiative
2022
Kenya Medical Research Institute
2021
University of Helsinki
2018-2019
Maasai Mara University
2019
Helsinki University Hospital
2018-2019
Public Health Agency of Sweden
2019
Karolinska University Hospital
2019
Swedish Veterinary Agency
2019
University of Arkansas at Fayetteville
2019
Bombali virus (genus Ebolavirus) was identified in organs and excreta of an Angolan free-tailed bat (Mops condylurus) Kenya. Complete genome analysis revealed 98% nucleotide sequence similarity to the prototype from Sierra Leone. No Ebola virus-specific RNA or antibodies were detected febrile humans area who reported contact with bats.
The lower than expected COVID-19 morbidity and mortality in Africa has been attributed to multiple factors, including weak surveillance. This study estimated the burden of SARS-CoV-2 infections eight months into epidemic Nairobi, Kenya.A population-based, cross-sectional survey was conducted using multi-stage random sampling select households within Nairobi November 2020. Sera from consenting household members were tested for antibodies SARS-CoV-2. Seroprevalence after adjusting population...
Methicillin-resistant Staphylococcus aureus (MRSA) is associated with significant morbidity and mortality has resultant important economic societal costs underscoring the need for accurate surveillance. In recent years, prevalence rates reported in East Africa have been inconsistent, sparking controversy raising concern. We described antimicrobial susceptibility patterns of isolates cultured from patients within Internal Medicine department largest public healthcare facility Central Africa-...
Background Vaccines against human papillomavirus (HPV) infection have the potential to reduce burden of cervical cancer. School-based delivery HPV vaccines is cost-effective and successful uptake depends on school teachers' knowledge acceptability vaccine. The aim this study assess primary vaccine explore facilitators barriers an ongoing Gavi Alliance-supported vaccination program in Kitui County, Kenya. Methods This was a cross-sectional, mixed methods Central Division County where Ministry...
To determine antibiotic susceptibility pattern of S. aureus isolates from clinical specimens collected patients at Kenyatta National Hospital March 2014–February 2016, and to the prevalence quarterly trends MRSA throughout study period. A total 944 were analyzed. High sensitivity was observed for quinupristin/dalfopristin (100%), tigecycline (98.2), imipenem (98%), nitrofurantoin (97.6%), linezolid (97.3%), teicoplanin (97.1%) vancomycin (95.1%). resistance recorded against penicillin G...
Mobile phone penetration has increased exponentially over the last decade as its application in nearly all spheres of life including health and medical education. This study aimed at assessing use mobile learning technology challenges among final year undergraduate students College Health sciences, University Nairobi.This was a cross-sectional descriptive conducted Nairobi, Sciences. Self-administered, anonymous questionnaires were issued to their lecture rooms after obtaining informed...
We describe the first genome isolation of Middle East respiratory syndrome coronavirus (MERS-CoV) in Kenya. This fatal zoonotic pathogen was described Kingdom Saudi Arabia 2012. Epidemiological and molecular evidence revealed transmission from camels to humans between humans. Currently, MERS-CoV is classified by WHO as having high pandemic potential requiring greater surveillance. Previous studies Kenya mainly focused on site-specific archived camel human serum samples for antibodies....
There is worldwide concern of rapidly increasing antimicrobial resistance (AMR). However, there paucity surveillance data and updated antibiograms in Africa general. This study was undertaken Kenyatta National Hospital (KNH) -the largest public tertiary referral centre East & Central Africa-to help bridge existing AMR knowledge practice gaps.A retrospective review VITEK 2 (bioMérieux) records capturing susceptibility for the year 2015 done analysed using WHONET SPSS.Analysis 624 isolates...
The ongoing COVID-19 pandemic highlights the need to tackle viral variants, expand number of antigens, and assess diverse delivery systems for vaccines against emerging viruses. In present study, a DNA vaccine candidate was generated by combining in tandem envelope protein domain III (EDIII) dengue virus serotypes 1-4 (DENV)-2 non-structural 1 (NS1) protein-coding region. Each designed as serotype-specific consensus coding sequence derived from different genotypes based on whole genome...
Previously identified only in Sierra Leone, Guinea, and southeastern Kenya, Bombali virus-infected Mops condylurus bats were recently found »750 km away western Kenya. This finding supports the role of M. as hosts potential for virus circulation across bats' range sub-Saharan Africa.
ABSTRACTTick-borne viruses (TBVs) capable of transmitting between ticks and hosts have been increasingly recognized as a global public health concern. In this study, Hyalomma serum samples from camels were collected using recorded sampling correlations in eastern Kenya. Viromes pooled profiled by metagenomic sequencing, revealing diverse community related to at least 11 families. Five highly abundant viruses, including three novel (Iftin tick virus, Mbalambala virus [MATV], Bangali torovirus...
Development of next-generation sequencing and metagenomics has revolutionized detection novel viruses. Among these viruses are 3 human protoparvoviruses: bufavirus, tusavirus, cutavirus. These have been detected in feces children with diarrhea. In addition, cutavirus skin biopsy specimens cutaneous T-cell lymphoma patients France 1 melanoma patient Denmark. We studied seroprevalences IgG against various populations (n = 840), found a striking geographic difference prevalence bufavirus IgG....
Antimicrobial resistance (AMR) is a growing problem globally especially in Sub-Saharan Africa including Kenya. Without any intervention, lower/middle-income countries (LMICs) will be most affected due to already higher AMR levels compared with income and the far burden of diseases LMICs. Studies have consistently shown that inappropriate use antimicrobials major driver AMR. To address this challenge, hospitals are now implementing antibiotic stewardship programmes (ASPs), which been achieve...
Abstract In Kenya, HIV-1 key populations including men having sex with (MSM), people who inject drugs (PWID) and female workers (FSW) are thought to significantly contribute transmission in the wider, mostly heterosexual (HET) network. However, clear data on dynamics within between these groups limited. We aimed empirically quantify rates of flow HET population, as well different geographic regions determine ‘hotspots’ their contribution Kenya. used maximum-likelihood phylogenetic Bayesian...
Infection due to multidrug-resistant microorganisms is a growing threat in healthcare settings. Acinetobacter species specifically A. baumannii increasingly becoming resistant most antimicrobial agents recommended for treatment. This study aimed determine the susceptibility pattern of isolated from patients Kenyatta National Hospital.We conducted retrospective based on VITEK 2 (BioMérieux) electronic records capturing identification and isolates patient samples analyzed between 2013 2015 at...
Objective Multidrug-resistant organisms (MDRO), especially carbapenem-resistant (CRO), represent a threat for newborns. This study investigates the colonization prevalence of these pathogens in newborn unit at Kenyan tertiary hospital an integrated approach combining routine microbiology, whole genome sequencing (WGS) and surveillance data. Methods The was performed Kenyatta National Hospital (KNH) 2019 over four-month period included 300 mother-baby pairs. A total 1,097 swabs from newborns...
Background: The lower-than-expected COVID-19 morbidity and mortality in Africa has been attributed to multiple factors, including weak surveillance. We set out estimate the burden of SARS-CoV-2 infections eight months into epidemic Nairobi, Kenya.Methods: conducted a population based cross-sectional survey using multi-stage random sampling select households within Nairobi November 2020. Sera from consenting household members were tested for IgM IgG antibodies SARS-CoV-2. Seroprevalence was...
diabetic foot ulcer is the leading cause of hospital admissions, lower limb amputation and death among patients. Little information available on fungal isolation in patients, especially sub-Saharan Africa. This study aimed to describe Candida species infecting ulcers patients receiving clinical care at Kenyatta National Hospital assess their antifungal susceptibility profile.this was a cross-sectional carried out adult over three-month period. Species identification performed using VITEK - 2...
Dengue virus (DENV) has caused recent outbreaks in coastal cities of Kenya, but the epidemiological situation other areas Kenya is largely unknown. We investigated role DENV infection as a cause acute febrile disease non-epidemic settings rural and urban study Kenya. Altogether, 560 patients were sampled 2016–2017 Taita–Taveta County (n = 327) slums Kibera, Nairobi 233). The samples studied for IgM, IgG, NS1 antigen flaviviral RNA. IgG seroprevalence was found to be higher (14%) than (3%)....
coronaviruses are highly contagious and healthcare workers at a higher risk of contracting the disease. The objective this study was to assess level knowledge, perception, preparedness for coronavirus disease 2019 vaccine acceptability among in Kenya.a cross-sectional conducted from December 2020 January 2021. A link an online self-administered questionnaire disseminated health across country. SPSS version 20 used data analysis. Bivariate correlation analyses were determine associations...
Africa has one of the highest incidences gonorrhea. Neisseria gonorrhoeae is gaining resistance to most available antibiotics, compromising treatment across world. Whole-genome sequencing (WGS) an efficient way predicting AMR determinants and their spread in population. Recent advances next-generation technologies like Oxford Nanopore Technology (ONT) have helped generation longer reads DNA a shorter duration with lower cost. Increasing accuracy base-calling algorithms, high throughput,...
We found similar mild perivascular inflammation in lungs of Bombali virus-positive and -negative Mops condylurus bats Kenya, indicating the virus is well-tolerated. Our findings indicate M. may be a reservoir host for virus. Increased surveillance these will important to reduce potential spread.
Background: Effective control of malaria requires knowledge vector species, their feeding and resting behaviour as well breeding habitats. The objective this study was to determine species abundance identify larval habitats in Huye district, southern Rwanda.Methods: Adult mosquitoes were collected indoors using light trap pyrethrum spray catch techniques, outdoors traps. Female Anopheles identified level by morphological characteristics. Enzyme-linked Immunosorbent Assay (ELISA) used screen...