A5003521417- Fungal Infections and Studies
- COVID-19 epidemiological studies
- Viral Infections and Outbreaks Research
- COVID-19 Clinical Research Studies
- Rabies epidemiology and control
- SARS-CoV-2 and COVID-19 Research
- Salivary Gland Tumors Diagnosis and Treatment
- Virology and Viral Diseases
- Antimicrobial Resistance in Staphylococcus
- Enterobacteriaceae and Cronobacter Research
- Poxvirus research and outbreaks
- Bacterial Identification and Susceptibility Testing
- Influenza Virus Research Studies
- Diphtheria, Corynebacterium, and Tetanus
- COVID-19 Pandemic Impacts
- Vibrio bacteria research studies
- Phytoplasmas and Hemiptera pathogens
- Pneumonia and Respiratory Infections
- Burkholderia infections and melioidosis
- Animal Disease Management and Epidemiology
- Mycobacterium research and diagnosis
- Cytomegalovirus and herpesvirus research
- Microbial infections and disease research
- SARS-CoV-2 detection and testing
- Salmonella and Campylobacter epidemiology
University of Nairobi
2013-2024
Kenyatta National Hospital
2016
Therapeutics Clinical Research
2010
Brucellosis is a common bacterial zoonotic infection but data on the prevalence among humans and animals limited in Kenya. A cross-sectional survey was conducted three counties practicing different livestock production systems to simultaneously assess seroprevalence of, risk factors for brucellosis their (cattle, sheep, camels, goats). two-stage cluster sampling method with random selection of sublocations households conducted. Blood samples were collected from tested Brucella immunoglobulin...
Methicillin-resistant Staphylococcus aureus (MRSA) is associated with significant morbidity and mortality has resultant important economic societal costs underscoring the need for accurate surveillance. In recent years, prevalence rates reported in East Africa have been inconsistent, sparking controversy raising concern. We described antimicrobial susceptibility patterns of isolates cultured from patients within Internal Medicine department largest public healthcare facility Central Africa-...
We estimated unit costs for COVID-19 case management patients with asymptomatic, mild-to-moderate, severe and critical disease in Kenya.We per-day of patients. used a bottom-up approach to estimate full economic adopted health system perspective patient episode care as our time horizon. obtained data on inputs their quantities from provided by three public treatment hospitals Kenya augmented this guidelines. input prices recent costing survey 20 market Kenya.Per-day, per-patient asymptomatic...
There is worldwide concern of rapidly increasing antimicrobial resistance (AMR). However, there paucity surveillance data and updated antibiograms in Africa general. This study was undertaken Kenyatta National Hospital (KNH) -the largest public tertiary referral centre East & Central Africa-to help bridge existing AMR knowledge practice gaps.A retrospective review VITEK 2 (bioMérieux) records capturing susceptibility for the year 2015 done analysed using WHONET SPSS.Analysis 624 isolates...
Objectives To assess outcomes of patients admitted to hospital with COVID-19 and determine the predictors mortality. Setting This study was conducted in six facilities, which included both government privately run secondary tertiary level facilities central coastal regions Kenya. Participants We enrolled 787 reverse transcriptase-PCR-confirmed SARS-CoV2-infected persons. Patients whose records could not be accessed were excluded. Primary outcome measures The primary COVID-19-related death....
In 2014 the Kenya National Immunization Technical Advisory Group (KENITAG) was asked by Ministry of Health to provide an evidence-based recommendation on whether seasonal influenza vaccine should be introduced into national immunization program (NIP).We reviewed KENITAG manuals, reports and meeting minutes generated between June 2016 in order describe process used arriving at that challenges encountered.KENITAG developed a framework identify critical, important non-critical data elements...
In Africa, rabies causes an estimated 24,000 human deaths annually. Mass dog vaccinations coupled with timely post-exposure prophylaxis (PEP) for dog-bite patients are the main interventions to eliminate deaths. A well-informed healthcare workforce and availability accessibility of biologicals at health facilities critical in reducing We assessed awareness knowledge regarding management among workers, PEP rural eastern Kenya.
Abstract Background More than 49,000 cases of infection and 900 deaths from COVID-19 have been recorded in the Kenya. However, characteristics risk factors for severe outcomes among hospitalized patients this setting not described. Methods We extracted demographic, laboratory, clinical outcome data medical records RT-PCR confirmed SARS-CoV2 admitted six hospitals Kenya between March September, 2020. used Cox proportional hazards regressions to determine related in-hospital mortality. Results...
The World Health Organization (WHO) estimates that acute lower respiratory infections account for 4 million deaths per year. rates are even higher in developing countries. Influenza, a virus causing infections, has widely been studied developed However, there is paucity of data on its epidemiology, seasonality and burden most In the contrary, Kenya (a country) an elaborate national epidemio-surveillance network influenza, where lot generated epidemiology influenza East African region....
The objective of this study was to evaluate the performance lateral flow immunoassay (LFA) against latex agglutination (LA), India ink and culture in point-of-care diagnosis cryptococcus meningitis (CM). We conducted cross-sectional among HIV-positive patients with suspected CM at Mbagathi Hospital, Nairobi, April-July 2017.Of 124 capillary blood serum 99 cerebrospinal fluid (CSF) samples, LFA LA had a concurrence on 94.4%, kappa (0.88), sensitivity (100%) specificity (91%). CSF, 97.9%,...
Abstract Introduction Case management for COVID-19 patients is one of key interventions in country responses to the pandemic. Countries need information on costs case inform resource mobilization, planning and budgeting, purchasing arrangements, assessments cost-effectiveness interventions. We estimated unit with asymptomatic, mild moderate, severe, critical disease Kenya. Methods per patient day that are asymptomatic those have symptoms. For moderate patients, we home-based care...
The yield of bacterial cultures from cerebrospinal fluid (CSF) at Kenyatta National Hospital (KNH) is very low. Bedside inoculation culture media with CSF may improve yields.To compare the inoculated onto medium bedside to that in microbiology laboratory.Cross-sectional comparative study.Accident and Emergency Department medical wards Hospital.Cerebrospinal patients KNH a clinical diagnosis acute meningitis.Two hundred twenty specimens were obtained during four month period. S. pneumaniae...
<title>Abstract</title> <bold>Background: </bold>Rabies remains a major public health problem in low- and middle-income countries. However, human rabies deaths are rarely laboratory-confirmed, especially Africa. Here, we use virus sequence data to enhance investigations for series of 5 East Africa discuss the implications these at individual, healthcare, societal-level. <bold>Case presentation: </bold>The epidemiological context care cases is contrasting: three bite victims did not receive...
Initial transmission of severe acute respiratory syndrome virus-2 (SARS-CoV-2) was highest in densely populated regions Kenya. Transmission gradually trickled down to the less populated, remote and underserved such as pastoral Kajiado County which are characterized by poor healthcare systems. Molecular assays that were pivotal for COVID-19 diagnosis not available these regions. Serology is an alternative method retrospectively tracking SARS-CoV-2 populations. Dry blood spots (DBS) prepared...
Abstract Objectives: The objective of this study was to evaluate the performance lateral flow immunoassay (LFA) against latex agglutination (LA), India ink and culture in point-of-care diagnosis CM. We conducted a cross-sectional among patients with suspected CM at Mbagathi Hospital, Nairobi, April-July 2017. Results: Of 124 capillary blood serum 99 cerebrospinal fluid (CSF) samples, agreement between LFA LA on 94.4%, kappa (0.88), sensitivity (100%) specificity (91%). CSF, 97.9%, (0.96),...
Abstract Objectives: The objective of this study was to evaluate the performance lateral flow immunoassay (LFA) against latex agglutination (LA), India ink and culture in point-of-care diagnosis Cryptococcus meningitis (CM). We conducted a cross-sectional among patients with suspected CM at Mbagathi Hospital, Nairobi, April-July 2017. Results: Of 124 capillary blood serum 99 cerebrospinal fluid (CSF) samples, agreement between LFA LA on 94.4%, kappa (0.88), sensitivity (100%) specificity...
Abstract Objectives: The objective of this study was to evaluate the performance lateral flow immunoassay (LFA) against latex agglutination (LA), India ink and culture in point-of-care diagnosis Cryptococcus meningitis (CM). We conducted a cross-sectional among HIV-positive patients with suspected CM at Mbagathi Hospital, Nairobi, April-July 2017. Results: Of 124 capillary blood serum 99 cerebrospinal fluid (CSF) samples, LFA LA had concurrence on 94.4%, kappa (0.88), sensitivity (100%)...
Introduction: Tetanus is a major health problem in developing countries, and associated with high morbidity mortality. There are no recent local data Kenya on the impact of disease terms The objective this study was to describe type, severity, risk factors, immunization history outcome tetanus patients at Kenyatta National Hospital (KNH).
 Method: This retrospective descriptive clinical diagnosis admitted KNH over ten years, who were aged 13 years above. All available files selected,...