Jānis Zariņš

ORCID: 0000-0003-1168-0921
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About
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Research Areas
  • Reconstructive Surgery and Microvascular Techniques
  • Bone Tissue Engineering Materials
  • Bone fractures and treatments
  • Bone Metabolism and Diseases
  • Congenital limb and hand anomalies
  • Bone health and osteoporosis research
  • Orthopaedic implants and arthroplasty
  • Sarcoma Diagnosis and Treatment
  • Dental Implant Techniques and Outcomes
  • Hemostasis and retained surgical items
  • Orthopedic Surgery and Rehabilitation
  • Cardiac, Anesthesia and Surgical Outcomes
  • Orthopedic Infections and Treatments
  • Tumors and Oncological Cases
  • Oral and Maxillofacial Pathology
  • Venous Thromboembolism Diagnosis and Management
  • Cleft Lip and Palate Research
  • Vascular Procedures and Complications
  • Thallium and Germanium Studies
  • Boron Compounds in Chemistry
  • Head and Neck Cancer Studies
  • TGF-β signaling in diseases
  • Education, Achievement, and Giftedness
  • Nonmelanoma Skin Cancer Studies
  • Actinomycetales infections and treatment

Riga Technical University
2023-2025

Riga East University Hospital
2016-2021

Riga Stradiņš University
2016-2021

Plastic Electronic (Austria)
2021

Radiation therapy is a recognized etiological factor for osteomyelitis, osteoradionecrosis and multiple sarcomas such as chondrosarcoma osteosarcoma. Here we present case of mandibular chondroblastic type osteosarcoma induced by radiotherapy which was primarily misdiagnosed chondrosarcoma. A female presented with main complaint pain at the extraction site following teeth sequestrectomy on right lower jaw. Medical history revealed stage IV squamous cell carcinoma base tongue treated surgical...

10.18203/issn.2454-2156.intjscirep20250351 article EN International Journal of Scientific Reports 2025-02-06

Microvascular flap surgery is a widely used procedure for the reconstruction of various defects. Data on laboratory biomarkers prediction complications are currently limited. We aimed to investigate link between preoperative fibrinogen-to-albumin ratio (FAR) and complications. This prospective cohort study included 130 adult patients who underwent elective microvascular surgery. Preoperative blood samples analysis plasma fibrinogen (g/L) albumin were collected day before initiating...

10.1016/j.jpra.2025.03.022 article EN cc-by-nc-nd JPRAS Open 2025-04-01

Background and Objectives: Microvascular flap surgery is a widely used reconstructive technique for the repair of various defects. Biomarkers have become an essential tool monitoring viability, early detection complications, prediction surgical outcomes. Studies focusing on immunomodulatory cytokines in microvascular complications are lacking. We aimed to investigate predictive value postoperative changes transforming growth factor beta-1 (TGF-β1) complications. Materials Methods: This...

10.3390/medicina61050863 article EN cc-by Medicina 2025-05-08

Background: Strontium (Sr) enriched biomaterials have been used to improve bone regeneration in vivo. However, most studies provide only two experimental groups. The aim of our study was compare eleven different sample groups from osteoporotic and healthy rabbits’ femoral neck, as it is the frequent fracture humans. Methods: Osteoporotic defects were filled with hydroxyapatite 30% (HA) tricalcium phosphate 70% (TCP), 5% Sr-enriched HA30/TCP70, HA70/TCP30, or Sr-HA70/TCP30 granules compared...

10.3390/sym11020229 article EN Symmetry 2019-02-14

: Microvascular flap surgery has become a routine option for defect correction. The role of von Willebrand factor antigen (VWF:Ag) in the pathophysiology complications is not fully understood. We aim to investigate predictive value VWF:Ag microvascular and explore relationship between chronic inflammation VWF:Ag.

10.3390/jcm13185411 article EN Journal of Clinical Medicine 2024-09-12

Summary Osteoporosis and other pathological bone conditions can impair regeneration properties, consuming in increased morbidity decreased quality of life. Changes healing result poor osteointegration surgical failures if implants are used. To overcome facilitate regeneration, more attempts made to develop an ideal synthetic scaffold with better biocompatibility, osteoconductivity, bioactivity, osteoinductivity interconnected porosity. It is considered that strontium, being similar calcium,...

10.1515/chilat-2017-0004 article EN Acta Chirurgica Latviensis 2016-12-01

Microvascular flap surgery is a widely acknowledged procedure for significant defect reconstruction. Multiple complication risk factors have been identified, yet there are limited data on laboratory biomarkers the prediction of loss. The controlling nutritional status (CONUT) score has demonstrated good postoperative outcome assessment ability in diverse surgical populations. We aim to assess predictive value CONUT complications microvascular surgery. This prospective cohort study includes...

10.3390/jcm12144794 article EN Journal of Clinical Medicine 2023-07-20

The first toe-to-hand transplantation was done in 1898 by Nicoladoni. It a staged procedure and the toe flap based on pedicle. With advancement of optical instruments microsurgeons' skills 1964 microvascular rhesus monkey done. technique's development has not stopped, many authors have modified it to achieve better outcomes for both traumatic congenital hand defects. most commonly used toes are first, second, second third block. Well described plantar dorsal vascular systems web space...

10.1097/bth.0000000000000234 article EN Techniques in Hand and Upper Extremity Surgery 2019-02-02

Background and Objective: Thrombosis due to inherited hypercoagulability is an issue that has been raised in microvascular flap surgery previously. We analyzed the association of a single nucleotide polymorphism (SNP) rs2066865 fibrinogen gamma chain (FGG) gene, alteration plasma concentration, presence thrombosis. Materials Methods: A total 104 adult patients with were subjected analysis SNP FGG gene. Alterations concentration according genotype determined as primary outcome, thrombosis was...

10.3390/medicina55090563 article EN cc-by Medicina 2019-09-03

MPNST is a rare type of malignancy classified as malignant soft tissue sarcoma. One-fourth to one-half arise in patients with neurofibromatosis 1 (NF1) and generally involves major nerve trunks proximal extremities body, rarely head neck region. Aggressive nature the disease shows poor overall prognosis, where treatment modalities are also limited.62-year-old otherwise healthy female underwent radical surgical due mass right side neck. Preoperative MRI studies showed well defined partly...

10.1016/j.ijscr.2023.107940 article EN International Journal of Surgery Case Reports 2023-02-18

Abstract Congenital thumb hypoplasia is a rare deformity of the upper extremity. Incidence type I–V was 2–3 and IIIb-V 0.5–1 per 20 000 newborns year in Latvia. The classification created by Blauth 1967 (type I to V). base metacarpal bone absent for IIIb–V; therefore, toe-to hand transplantation not recommended. A stable first carpometacarpal joint has been considered mandatory factor successful toe-to-hand transplantation. technique IIIb–V patients described literature but overall results...

10.2478/prolas-2019-0027 article EN Proceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences 2019-04-07

Summary Introduction. Congenital anomalies are rare, affecting 1-2% of new-borns and only 10% them have upper limb defects. Incidence forearm longitudinal deficiencies is 1:55 000-1:100 000 live births which means that 1 case in every two to four years can be expected Latvia. Centralisation surgical procedure was the main treatment option until 2008, but it had worst functional outcome (as literature data also show). Starting from 2010, several new techniques like microvascular...

10.1515/chilat-2015-0005 article EN Acta Chirurgica Latviensis 2014-12-01

Variety of different bone substitutive materials are synthetized to improve healing potentials in pathological conditions. Physiologically active molecules within biomaterials, can initiate expression level biomarkers, regulating remodeling. Aim our study was analyze process defects followed by implantation with 5% strontium substituted hydroxyapatite (HAP) /tricalcium phosphate (TCP) 70/30 granules (group A) or HAP/TCP biphasic ceramic without substitution B), sham surgery affected C)...

10.4028/www.scientific.net/ssp.267.124 article EN Diffusion and defect data, solid state data. Part B, Solid state phenomena/Solid state phenomena 2017-10-10

The new dorsal osteosynthesis (reconstruction) approach was developed to reduce the risks of plate exposure, infection, and early removal in difficult cases such as Gustilo–Anderson type IIIB or C open tibial fractures Cierny–Mader III IV chronic osteomyelitis. advantages this method are that reconstruction with microvascular pedicle fibula flaps plating can be done through healthy noncompromised posterior compartment—no separate incision for flap insertion is needed.

10.1055/s-0035-1570532 article EN cc-by-nc-nd Journal of Reconstructive Microsurgery Open 2016-01-21

Abstract Surgical treatment for patients with actinomycosis head and neck reconstruction should be considered as a reliable option good long‐term effect.

10.1002/ccr3.3986 article EN Clinical Case Reports 2021-03-13
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