A5055069947- Helicobacter pylori-related gastroenterology studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Gastroesophageal reflux and treatments
- Immunodeficiency and Autoimmune Disorders
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Virus-based gene therapy research
- Metabolism, Diabetes, and Cancer
- Lymphoma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- CAR-T cell therapy research
- Nitric Oxide and Endothelin Effects
- Immunotherapy and Immune Responses
- Pediatric health and respiratory diseases
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Cutaneous Melanoma Detection and Management
- Breast Lesions and Carcinomas
- Cancer, Lipids, and Metabolism
- Genetic factors in colorectal cancer
- Neuroinflammation and Neurodegeneration Mechanisms
University of Latvia
2016-2025
Riga East University Hospital
2014-2023
Unidad de Cirugía Artroscópica
2018
Foundation for Ichthyosis and Related Skin Types
2018
Latvia University of Life Sciences and Technologies
2018
Latvijas Organiskās Sintēzes Institūts
2010-2017
Riga Stradiņš University
2015-2016
Hull and East Yorkshire Hospitals NHS Trust
2016
Pauls Stradiņš Clinical University Hospital
2011-2016
GTx (United States)
2014
Abstract In solid tumors, the presence of lymph node–like structures called tertiary lymphoid (TLS) is associated with improved patient survival. However, little known about how TLS develop in cancer, their function affects survival, and whether they are affected by cancer therapy. this study, we used multispectral microscopy, quantitative pathology, gene expression profiling to analyze formation human lung squamous cell carcinoma (LSCC) an experimental model induction. We identified a niche...
Introduction Population-based eradication of Helicobacter pylori has been suggested to be cost-effective and is recommended by international guidelines. However, the potential adverse effects widespread antibiotic use that this would entail have not sufficiently studied. An alternative way decrease gastric cancer mortality non-invasive search for precancerous lesions, in particular atrophy; pepsinogen tests are best currently available alternative. The primary objective GISTAR determine...
Oncolytic virotherapy is a recent addition to cancer treatment. Here, we describe positive treatment outcomes in three patients using Rigvir virotherapy. One of the diagnosed with melanoma stage IV M1c, one small cell lung IIIA, and histiocytic sarcoma IV. The diagnoses all are verified by histology or cytology. All started within few months after being currently continuing degree regression disease has been determined computed tomography. Safety assessment adverse events graded according...
CD4+CD25+ FOXP3-positive T-regulatory cells have an important role in controlling immune and inflammatory reactions. The present authors hypothesise that these may be involved the pathogenesis of chronic obstructive pulmonary disease (COPD). aim study was to characterise expression FOXP3 large small airways nonsmokers, smokers with normal lung function COPD patients. A total 19 20 moderate COPD, undergoing resection for a solitary peripheral nonsmall cell carcinoma, were enrolled study....
Background: Chronic obstructive pulmonary disease (COPD) is characterised by progressive and irreversible airway obstruction. Smoking causes persistent inflammation in lung tissue. However, differences inflammatory responses between the large small airways have not been systematically explored among smokers with without COPD. Objectives: The aim of our research was to characterise expression localisation NF-ĸBp65 histone deacetylase 2 (HDAC2) as well cell (macrophages, lymphocytes,...
Objectives It is important to stratify patients according the magnitude of risk for gastric cancer development; OLGA (Operative Link Gastritis Assessment) and OLGIM on Gastric Intestinal Metaplasia) staging systems lesions in stomach mucosa have been proposed this purpose. There are some discrepancies current guidelines regarding value incisura angularis biopsies. The aim our study was assess biopsy gastritis by examining atrophic, metaplastic inflammatory changes antrum, corpus. Patients...
Abstract Background Circulating levels of pepsinogens have been used in high gastric cancer‐risk Asian and European populations to triage endoscopic evaluation for more severe pathology. There are different analytic methods with uncertain correlations. We therefore compared diagnostic performance three commonly pepsinogen assays detect histologically confirmed atrophy. Methods tested plasma samples from adult patients (n=50) without (n=755) moderate or corpus atrophy, as determined by...
Background/Objectives: Despite advances in diagnostic techniques, accurate classification of lung cancer subtypes remains crucial for treatment planning. Traditional methods like genomic studies face limitations such as high cost and complexity. This study investigates whether integrating atomic force microscopy (AFM) measurements with conventional clinical histopathological data can improve subtype classification. Methods: We developed analyzed a novel dataset combining clinical,...
Context: Metformin improves hyperglycaemia via mechanisms which include activation of AMP-activated protein kinase (AMPK). Recent findings indicate that some metabolic actions metformin occur also by AMPK-independent mechanisms.Objective: To study the action on expression GLUT1 glucose transporter in rat streptozotocin model diabetes mellitus.Materials and methods: Streptozotocin-induced rats were treated with while monitoring parameters carbohydrate lipid metabolism. mRNA kidneys, heart,...
Hotspot mutations of the BRAF and NRAS genes are most common genetic alterations in invasive cutaneous melanoma; however, prognostic significance co-mutations remains controversial. The present study aimed to determine association between mutation status clinicopathological characteristics patients with stage IA-IIC melanoma. A total 118 who underwent surgical treatment for melanoma at Riga East University Hospital 2012 2018 were retrospectively enrolled study. was assessed by digital...
Background and Objective. Glucose transport via GLUT1 protein could be one of additional mechanisms the antidiabetic action sulfonylureas. Here, gene expression was studied in rats course severe mild streptozotocin-induced diabetes mellitus under glibenclamide treatment. Material Methods. Severe induced using different streptozotocin doses standard or high fat chow. Rats were treated with (2 mg/kg daily, per os for 6 weeks). The therapeutic effect monitored by measuring several metabolic...
Background: Serum autoantibodies against tumor-associated antigens (TAAs) are detectable in early-stage gastric cancer patients; however, the time point during cancerogenesis when they appear circulation is still obscure.Methods: In this study, we developed a recombinant antigen microarray and analyzed prevalence of 102 TAAs 829 patients 929 healthy controls from Caucasian Asian populations, as well 100 with chronic atrophic gastritis 775 individuals staged according to different grades...
We aimed to determine the diagnostic value of anti-parietal cell antibodies (anti-PCA), anti-intrinsic factor (anti-IFA), pepsinogen ratio (PGI/II), and gastrin-17 (G-17) in corpus-restricted atrophic gastritis (CRAG) detected by ELISA (Inova, Biohit). Our study compared 29 CRAG cases against 58 age- sex-matched controls with mild or no atrophy. Anti-PCA anti-IFA positive cutoff values were ≥25 units for both. PGI/II <3 was considered characteristic atrophy; G-17 anti-H. pylori IgG >5...
Anti-ischaemic drug mildronate suppresses fatty acid metabolism and increases glucose utilization in myocardium. It was proposed that it could produce a favourable effect on metabolic parameters transport diabetic animals. Rats with streptozotocin diabetes mellitus were treated (100 mg/kg daily, per os, 6 weeks). Therapeutic of monitored by measuring animal weight, concentrations blood glucose, insulin, triglycerides, free acids, ketone bodies cholesterol, glycated haemoglobin cent (HbA1c%)...
Cervical intraepithelial neoplasia (CIN) is a dysplastic process in cervical squamous epithelium and carries risk of progression to cancer. The aim this study was compare expression three biomarkers named p53, p63 Ki-67 patients with various grades control group.58 were enrolled the study. Each patient underwent colposcopy-guided biopsy cervix. Immunostaining for markers (p53, Ki-67) performed on tissue samples normal cases (n=10), CIN I (n=20), II (n=14), III (n=14).Our showed significant...
Abstract: The biochemical and histological sequelae resulting from a diet containing 50.20 mg cadmium/kg were studied in Lohmann brown cockerels hatching until 30 days of age. additional cadmium chloride (CdCl 2 ) to the induced formation lipid peroxides, which via chain reaction led accumulation malondialdehyde intestinal mucosa. At end study (after exposure) total protein metallothionein levels mucosa relative ileal duodenal weight increased. Histological data show that CdCl causes an...
When administered as drugs or consumed food components, polyphenolic compounds synthesized in plants interfere with intracellular signal transduction pathways, including pathways of nitric oxide synthase expression. However, effects these vivo do not always correlate synthase-inhibiting activities revealed experiments cultured cells. The initial goal this work was to compare flavonoids kaempferol and myricetin on inducible mRNA protein expression monitored by real-time RT-PCR...
Epstein-Barr virus (EBV)-associated gastric cancer has been proposed to be a distinct molecular subtype. The prognostic significance of EBV infection in remains unclear and needs further investigation. Our study aimed analyze EBV-positive EBV-negative patients regarding their personal tumor-related characteristics, compare overall survival.
Previously, we have found that mildronate [3-(2,2,2-trimethylhydrazinium) propionate dihydrate], a small molecule with charged nitrogen and oxygen atoms, protects mitochondrial metabolism is altered by inhibitors of complex I has neuroprotective effects in an azidothymidine-neurotoxicity mouse model. In the present study, investigated rat model Parkinson’s disease (PD) was generated via unilateral intrastriatal injection neurotoxin 6-hydroxydopamine (6‑OHDA). We assessed expression cell...
This review for the first time summarizes data obtained in neuropharmacological studies of mildronate, a drug previously known as cardioprotective agent. In different animal models neurotoxicity and neurodegenerative diseases, we demonstrated its neuroprotecting activity. By use immunohistochemical methods Western blot analysis, well some selected behavioral tests, new mechanisms mildronate have been demonstrated: regulatory effect on mitochondrial processes expression nerve cell proteins,...