Frequency of active human herpesvirus-6, -7 (HHV-6, HHV-7) and parvovirus B19 (B19) infection/coinfection its association with clinical course ME/CFS was evaluated. 108 patients 90 practically healthy persons were enrolled in the study. Viral genomic sequences detected by PCR, virus-specific antibodies cytokine levels-by ELISA, HHV-6 variants-by restriction analysis. Active viral infection including concurrent found 64.8% (70/108) 13.3% (12/90) persons. Increase peripheral blood leukocyte...

The complexity of autoimmunity initiation has been the subject many studies. Both genetic and environmental factors are essential in development. Among others, include infectious agents. HHV-6 is a ubiquitous human pathogen with high global prevalence. It several properties suggestive its contribution to broad cell tropism, ability establish latency subsequent reactivation persistence, range immunomodulation capabilities. Studies have implicated plethora autoimmune diseases—endocrine,...

Abstract The relationship between beta‐herpesviruses reactivation and the development of complications after autologous peripheral blood stem cell transplantation was investigated. Viral genomic sequences were detected by polymerase chain reaction, virus‐specific antibodies ELISA, human herpesvirus (HHV)‐6 variants restriction endonuclease analysis. Virus reactivation, serum levels tumor necrosis factor (TNF)‐α, interleukin (IL)‐1β, IL‐6, soluble IL‐2 receptor (sIL‐2R), IL‐2, IL‐4 compared...

Background and objectives: Composition of the peripheral blood (PB) cell populations their activation state reflect immune status a patient. Rheumatoid arthritis (RA) is characterized by abnormal B- T-cell functions. The objective this study was to assess profiles PB mononuclear (PBMC) in patients with rheumatoid osteoarthritis (OA) comparison healthy control (HC) subjects order evaluate PBMC as potential diagnostic characteristic RA. second aim CCR1 CCR2 expression on lymphocytes correlate...

The aim of this study was to investigate the role human herpesvirus-6 (HHV-6) in autoimmune thyroiditis (AIT) development. We examined possible involvement HHV-6 gene expression encoding immunomodulating proteins U12 and U51 AIT development their modulation chemokine signaling. One hundred patients with following thyroidectomy were enrolled study. Nested polymerase chain reaction (nPCR) used detect sequence DNA samples. Reverse transcription PCR (RT-PCR) three different targets (U79/80, U12)...

Objectives. Most of human papillomavirus (HPV) infections are “cleared” by the immune system; however, in cases system suppression, could lead to development malignancies. The aim this study was find out frequency HR-HPV infection early period after renal transplantation recipients receiving immunosuppressive therapy and follow progression up one year. Methods. 43 female transplant 79 healthy individuals as a control group were enrolled investigation. For detection HPV infection, patients’...

Human herpesvirus-6 (HHV-6) contains two genes (U12 and U51) that encode putative homologues of human G-protein-coupled receptors like CCR1, CCR3, CCR5. It has been shown these viral proteins can be expressed on the surface epithelial some peripheral blood mononuclear cells, suggesting they could potentially induce autoimmunity. We aimed to investigate possibility HHV-6 encoded chemokine involvement in autoimmune thyroiditis (AIT) development by detecting peptide specific antibodies AIT...

Laryngeal papillomatosis (LP) is the most common benign laryngeal tumor in children, but it can affect both children and adults. Although benign, this condition still remains hard to treat negatively affects patient quality of life as spread adjacent respiratory tract, recurs, requires repeated medical intervention. As surgical removal papillomas with preservation normal mucosa only standard care, there no for adjuvant therapy. In case report, we describe course recurrent a Caucasian male...

OBJECTIVES: Most of human papilomavirus (HPV) infections are “cleared” by the immune system, however, in cases system suppression could lead to development malignancies. The aim this study was find out frequency HR-HPV infection early period after renal transplantation Latvian recipients receiving immunosuppressive therapy and follow progression up one year. 
 METHODS: 43 female (median age 48 IQR= 39-58) 79 practically healthy individuals 42-57) as a control group were enrolled...

Abstract Human herpesvirus-6 (HHV-6) is a ubiquitous betaherpesvirus with immunomodulating properties that have been suggested to play an important role in the development of several autoimmune disorders. Although primary targets for HHV-6 replication, both vitro and vivo, are CD4+ CD8+ T lymphocytes, some studies reported presence sequences different solid organs, including thyroid gland, showing possible involvement this herpesvirus disease. The aim study was determine loads gland tissue...

Human papillomavirus type 18 is the second most common cause of cervical cancer and found in 7 to 20 % cases cancer. The oncogenic potential high-risk human associated with expression early proteins E6 E7. Due long-term immunosuppressive therapy, renal transplant recipients have a higher risk developing persistent infection. A 29-year-old white woman from Latvia chronic focal segmental glomerulosclerosis received allograft transplantation was prescribed therapy cyclosporine, prednisolone,...

OBJECTIVES: Most of human papilomavirus (HPV) infections are “cleared” by the immune system, however, in cases system suppression could lead to development malignancies. The aim this study was find out frequency HR-HPV infection early period after renal transplantation Latvian recipients receiving immunosuppressive therapy and follow progression up one year. METHODS: 43 female (median age 48 IQR= 39-58) 79 practically healthy individuals 42-57) as a control group were...

Abstract Kidney transplant recipients have higher incidence of human papillomavirus (HPV)-related malignancies, but studies on the natural history HPV infection are insufficient, especially regarding in male recipients. The aim this study was to evaluate course high-risk (HR-HPV) after kidney allograft transplantation recipients: estimate frequency and activity HR-HPV under immune system suppression. Twenty renal (age 20 - 68) were enrolled investigation examined dynamics. Peripheral...