A5088735734- Systemic Lupus Erythematosus Research
- Peripheral Artery Disease Management
- Systemic Sclerosis and Related Diseases
- Diabetes and associated disorders
- Peripheral Neuropathies and Disorders
- Atherosclerosis and Cardiovascular Diseases
- Lymphadenopathy Diagnosis and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Dermatological and COVID-19 studies
- Lipid metabolism and disorders
- Venous Thromboembolism Diagnosis and Management
- Soft tissue tumors and treatment
- Viral Infections and Immunology Research
- Complement system in diseases
- Diagnosis and Treatment of Venous Diseases
- Blood groups and transfusion
- Aortic Thrombus and Embolism
- Rheumatoid Arthritis Research and Therapies
- Eosinophilic Disorders and Syndromes
- Erythrocyte Function and Pathophysiology
- Blood disorders and treatments
- Lymphoma Diagnosis and Treatment
- Myasthenia Gravis and Thymoma
BioCruces Health research Institute
2014-2020
University of the Basque Country
2004-2017
Hospital de Cruces
2004-2007
Antimalarials have shown beneficial effects on systemic lupus erythematosus (SLE) activity. Our aim was to investigate whether antimalarials protect against thrombosis and influence survival in SLE patients. A prospective cohort including 232 patients with were included the study at time of diagnosis. End points documented death due any cause. Cox regression-multiple-failure analysis model fitted establish effect development thrombosis. Kaplan-Meier curves propensity score adjusted-Cox...
Objective To analyze the influence of 2 different treatment strategies on general and specific damage accrual in patients with systemic lupus erythematosus ( SLE ). Methods Two cohorts were identified according to responsible physicians: treated at autoimmune diseases unit ADU ), by other members internal medicine IM ) department. Members worked a protocol including universal prescription hydroxychloroquine HCQ use maximum oral prednisone dosages ≤30 mg/day maintenance therapy ≤5 mg/day,...
The incidence and severity of tuberculosis (TB) in patients with systemic lupus erythematosus (SLE) varies greatly among different series. In addition, prospective data are scarce. aim this study is to analyse the frequency TB our cohort patients. We analysed from a database single center 232 SLE (ACR criteria). Prophylaxis isoniazid was not regularly administered. identified all cases diagnosed during 10 years (January 1994 December 2003). following variables were analysed: annual TB,...
Fluctuations in the titers of anticardiolipin antibodies (aCL) have been reported systemic lupus erythematosus (SLE) patients, but their relation with thrombosis is not completely understood. Prospective inception cohort 237 patients SLE (American College Rheumatology criteria). Positivity for antiphospholipid (aPL) was defined according to Sapporo criteria. aCL as persistently positive when more than two-thirds determinations were during follow-up. Patients classified into four groups: A...
To analyze the results of cardiac valve replacement in a multicenter cohort patients with antiphospholipid syndrome (APS) and to identify prognostic factors poor outcome.We performed retrospective analysis clinical manifestations (cardiac involvement APS characteristics), operative early postoperative courses, long-term followup. All fulfilled Sapporo criteria for APS. Logistic regression analyses were those variables associated adverse outcomes.Between 1981 2008, 33 valvular replacements...
Objective. To analyze the prevalence of peripheral arterial disease (PAD) and cardiovascular (CV) risk factors in a cohort patients with systemic lupus erythematosus (SLE) to identify variables potentially related PAD. Methods. The study included 216 SLE from Lupus-Cruces prospective observational cohort. ankle brachial index (ABI) was determined each patient, values < 0.9 considered diagnostic Demographic clinical variables, presence traditional CV events, calculated by Systematic...
Objective To analyse the differential influence of risk factors peripheral artery disease (PAD) according to age in patients with SLE. Methods 216 from Lupus-Cruces cohort were divided three groups: ≤34 years, 35–49 years and ≥50 years. A low ankle–brachial index defined PAD. Significant variables identified by univariant multivariant analysis each group. Results Different different antiphospholipid antibodies/antiphospholipid syndrome glucocorticoids years; old, hypertension was only...
RESUMENLa enfermedad de Kikuchi Fujimoto es una forma inusual linfadenitis observada inicialmente en Japón.La etiología desconocida y afecta preferentemente a mujeres jóvenes cervical dolorosa asociado con frecuencia fiebre leucopenia.Se trata benigna resolución espontánea.La lesión histológica se caracteriza por fenómenos necróticos cariorrexis, pérdida parcial la estructura ganglionar focos histiocitos zona cortical y/o paracortical.Un hallazgo característico ausencia granulocitos...
<h3>Background</h3> Arterial vascular events (AVE) are among the major causes of morbidity and mortality in patients with Systemic Lupus Erythematosus (SLE). Several studies have been carried out to identify main factors related AVE this population. The ankle brachial index (ABI) is one tools currently used at greater risk arterial general population; however it has scarcely studied SLE. <h3>Objectives</h3> objectives prospective cohort study were determine predictive value ABI for...