A5045648910- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Nosocomial Infections in ICU
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Infective Endocarditis Diagnosis and Management
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Antifungal resistance and susceptibility
- Central Venous Catheters and Hemodialysis
- Fungal Infections and Studies
- SARS-CoV-2 and COVID-19 Research
- Legionella and Acanthamoeba research
- Intensive Care Unit Cognitive Disorders
- Cytomegalovirus and herpesvirus research
- Renal Transplantation Outcomes and Treatments
- Bacillus and Francisella bacterial research
- Reproductive tract infections research
- Vibrio bacteria research studies
- SARS-CoV-2 detection and testing
- Infectious Disease Case Reports and Treatments
- Transplantation: Methods and Outcomes
- Bacterial biofilms and quorum sensing
- Viral gastroenteritis research and epidemiology
Universidad Complutense de Madrid
2016-2025
Hospital General Universitario Gregorio Marañón
2016-2025
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2016-2025
GTx (United States)
2023
Centro de Investigación Biomédica en Red
2022
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2022
Hospital Clínico San Carlos
2022
Collaborative Group (United States)
2017
Creative Commons
2015
Hospital Universitario de Móstoles
2008-2012
Abstract Background There is a paucity of knowledge on the long-term outcome in patients diagnosed with COVID-19. We describe cohort constellation symptoms occurring four weeks after diagnosis causing different degrees reduced functional capacity. Although hypothesis have been proposed to explain this condition like persistent immune activation or immunological dysfunction, date, no physiopathological mechanism has identified. Consequently, there are therapeutic options besides symptomatic...
Microbiological confirmation of a urinary tract infection (UTI) takes 24–48 h. In the meantime, patients are usually given empirical antibiotics, sometimes inappropriately. We assessed feasibility sequentially performing Gram stain and MALDI-TOF MS mass spectrometry (MS) on urine samples to anticipate clinically useful information. May-June 2012, we randomly selected 1000 from with suspected UTI. All were stained those yielding bacteria single morphotype processed for MS. Our sequential...
Polymicrobial bloodstream infection (BSI) is an imprecisely defined entity purportedly associated with a worse outcome than monomicrobial BSI. This study examines trends in BSI episodes caused by bacteria and Candida spp. (mixed-BSI) large teaching hospital. All of from January 2000 to December 2010 were reviewed. Three groups (n = 54 each) patients compared: all adults mixed-BSI 2006 (cases) randomly selected polybacterial (polyB-BSI) (Control 1) or (Candida-BSI) 2) this same period. A...
A preclinical evaluation was conducted to evaluate the performance of Cepheid Xpert assay on 135 lower respiratory tract secretions for detection methicillin-resistant Staphylococcus aureus and S. aureus. Compared with quantitative culture, sensitivity, specificity, positive negative predictive values were 99.0%, 72.2%, 90.7%, 96.3%, respectively.
Purpose of review There are aspects skin and soft tissue infections (SSTIs) that remain unresolved, such as current numbers, classification criteria, how best to define severity predict the outcome, what diagnostic tests perform, new treatment options available, or duration antibiotic should be. We have reviewed literature over last 18 months clarify these issues provide our opinion. Recent findings SSTIs common among top 10 most frequent worldwide. They represent a burden on healthcare...
Background Despite the pathogenesis of vulvovaginal candidiasis (VVC) is multifactorial, this study aimed to assess whether phenotypic characteristics, such as biofilm production and quality, along with clinical symptoms, are associated recurrent VVC (RVVC). Methods Over 1 year (Oct 2021–Oct 2022), we prospectively included 271 patients ≥18 years who attended our institution, had Candida spp. isolated in vaginal swabs, provided informed consent. Patients were followed for year. isolates...
Valganciclovir (VGCV) and ganciclovir (GCV) doses must be adjusted according to indication, renal function weight. No specific therapeutic exposure values have been established. We aimed evaluate the adequacy of VGCV/GCV doses, assess interpatient variability in GCV serum levels, identify predictive factors for this clinical impact. This is a prospective study at tertiary institution including hospitalized patients receiving prophylaxis or treatment. Adequacy antiviral dose was defined...
Linezolid serum trough (Cmin) and peak (Cmax) levels were determined prospectively in 90 patients. Adequate exposure was defined as a Cmin of 2 to 8 mg/liter. Therapy empirical (73.3%) or targeted (26.7%). Wide interindividual variability linezolid recorded (0.1 25.2 μg/ml). Overall, 65.5% the patients had out-of-range, 41.1% subtherapeutic, 24.4% supratherapeutic levels. We did not find correlation between abnormal adverse events, in-hospital mortality, overall poor outcome.
This study examines the impacts of a skin and soft tissue infection (SSTI) management program involving rapid diagnostic algorithm (Gram stain plus real-time PCR, GeneXpert® MRSA/SA SSTI) performed directly on clinical samples antimicrobial stewardship (AMS) counseling responsible physician.Participants were 155 consecutive adult inpatients with SSTI good quality submitted to microbiology laboratory from April 2016 January 2017. Results test AMS recommendations phoned through physician. The...
There is a critical need for rapid diagnostic methods multidrug-resistant (MDR) pathogens in patients with suspicion of ventilator-associated pneumonia (VAP). The Xpert Carba-R detects 5 targets carbapenemase-producing organisms (blaKPC, blaNDM, blaVIM, blaOXA-48, and blaIMP-1). Our objective was to evaluate the performance this assay directly on bronchial aspirates correlate cycle number positive result (Ct) bacterial count. Bronchial from VAP were spiked dilution 1 4 MDR carrying...