Nicole García-Pouton
A5103228150- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Neutropenia and Cancer Infections
- Bacterial Identification and Susceptibility Testing
- COVID-19 and healthcare impacts
- Fungal Infections and Studies
- SARS-CoV-2 detection and testing
- Sepsis Diagnosis and Treatment
- COVID-19 diagnosis using AI
- Antibiotic Resistance in Bacteria
- Antifungal resistance and susceptibility
- Antibiotic Use and Resistance
- Infectious Encephalopathies and Encephalitis
- Intensive Care Unit Cognitive Disorders
- Artificial Intelligence in Healthcare and Education
- Pharmacological Receptor Mechanisms and Effects
- Machine Learning in Healthcare
- Olfactory and Sensory Function Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Microscopic Colitis
- Infective Endocarditis Diagnosis and Management
- Respiratory Support and Mechanisms
- Central Venous Catheters and Hemodialysis
- Gastrointestinal motility and disorders
Hospital Clínic de Barcelona
2020-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2020-2025
Universitat de Barcelona
2020-2022
BackgroundCalcium is an essential ion for pathogen survival and virulence involved in the regulation of inflammatory response. Hypocalcemia a common laboratory finding critically ill patients. Data regarding levels calcium SARS-CoV-2 infection scarce. Patients with who present hypocalcemia could have worse outcome.MethodsWe performed retrospective analysis hospitalized patients included all had any serum measurement first 72 h since hospital admission. The main objective was to investigate...
We aimed to describe changes in characteristics and treatment strategies of hospitalised patients with COVID-19 detail the mortality trend over time.
We analyzed risk factors for mortality in febrile neutropenic patients with bloodstream infections (BSI) presenting septic shock and assessed the impact of empirical antibiotic regimens. A multicenter retrospective study (2010 to 2019) two prospective cohorts compared BSI episodes or without shock.
Abstract Background The use of remdesivir has demonstrated a significant reduction in the time to recovery patients with COVID-19. However, impact on mortality is still controversial. Therefore, it necessary evaluate whether there specific subgroup whom an active antiviral therapy also reduces mortality. Methods Patients admitted for >48 h our hospital SARS-CoV-2 confirmed or suspected infection from February 2020 2021 were retrospectively analysed. primary outcome study was at 30...
Abstract Hospitalized patients with coronavirus disease 2019 (COVID-19) experiencing respiratory symptoms have different complications (inflammatory, co-infection, and thrombotic) that are identifiable by analytics patterns. Personalized treatment decisions decreased early mortality (odds ratio [OR] .144; 95% confidence interval [CI] .03–.686; P = .015). Increasing age (OR 1.06; .038) therapeutic effort limitation 9.684; < .001) were associated higher mortality.
We aimed to assess risk factors for multidrug-resistant Gram-negative bacilli (MDR-GNB) from a large amount of data retrieved electronic health records (EHRs) and determine whether machine learning (ML) may be useful in assessing the MDR-GNB infection at febrile neutropenia (FN) onset. Retrospective study almost 7 million pieces structured all consecutive episodes FN hematological patients tertiary hospital Barcelona (January 2008–December 2017). Conventional multivariate analysis ML...
Abstract Background In some patients the immune response triggered by SARS-CoV-2 is unbalanced, presenting an acute respiratory distress syndrome which in many cases requires intensive care unit (ICU) admission. The limitation of ICU beds has been one major burdens management worldwide; therefore, clinical strategies to avoid admission are needed. Objective We aimed describe influence tocilizumab on need transfer or death non-critically ill patients. Methods A retrospective study 171 with...
Background We aimed to describe the epidemiology of catheter-related bloodstream infections (CRBSIs) in onco-hematological neutropenic patients during a 25-year study period, evaluate risk factors for Gram-negative bacilli (GNB) CRBSI, as well rates inappropriate empirical antibiotic treatments (IEAT) and mortality. Materials/Methods All consecutive episodes CRBSIs were prospectively collected (1994–2018). Changing was evaluated comparing five-year time spans. A multivariate regression model...
Objectives. In some patients the immune response triggered by SARS-CoV-2 is unbalanced, presenting an acute respiratory distress syndrome which in many cases requires intensive care unit (ICU) admission. The limitation of ICU beds has been one major burdens management around world; therefore, clinical strategies to avoid admission are needed. We aimed describe influence tocilizumab on need transfer or death non-critically ill patients. Material and methods. A retrospective study 171 with...
Controversial results on remdesivir efficacy have been reported. We aimed to report our real-life experience with the use of from its availability in Spain. performed a descriptive study all patients admitted for ≥48 hours confirmed COVID-19 who received between 1st July and 30th September 2020. A total 123 out 242 at hospital (50.8%) remdesivir. Median age was 58 years, 61% were males 56.9 % least one anti-inflammatory treatment. No adverse events requiring discontinuation The need...
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We documented a hematologic patient with prolonged SARS-CoV-2 viral replication in whom emergence of mutations was after the consecutive use antivirals and convalescent plasma. The virus detected last 12 clinical samples (day 237) had accumulated 22 changes amino acids 29 nucleotides. Some these changes, such as E484Q, were concern defined by WHO. This finding represents an enormous epidemiological threat poses major challenge. Combined antiviral strategies, well specific strategies related...
In recent years, important epidemiologic changes have been described in hematopoietic stem cell transplantation (HSCT) recipients with bloodstream infection (BSI), increases gram-negative bacilli and multidrug resistant (MDR) bacilli. These linked to a worrisome increase mortality. We aimed define the risk factors for mortality of HSCT patients experiencing BSI. All episodes BSI between 2008 2017 were prospectively collected. Multivariate analyses performed. A total 402 documented 293 who...
Abstract Dexamethasone and tocilizumab have been associated with reduction in mortality, however, the beneficial effect is not for all patients impact on viral replication well defined. We hypostatized that C-reactive protein (CRP) could help identification of requiring anti-inflammatory therapy. Patients admitted > 48 h our hospital a confirmed or suspected infection by SARS-CoV-2 from February 2020 to 2021 were retrospectively evaluated. The primary outcome was mortality at 30 days....
Clinical data on which artificial intelligence (AI) algorithms are trained and tested provide the basis to improve diagnosis or treatment of infectious diseases (ID). We aimed identify important for ID research prioritise efforts being undertaken in AI programmes.We searched 1,000 articlesfrom high-impact journals PubMed, selecting 288 latest articles from 10 top journals. classified them into structured unstructured data. Variables were homogenised grouped following categories:...
Abstract Background There is no reliable microbiological marker to guide the indication and response antiviral treatment in patients with coronavirus disease 2019 (COVID-19). We aimed evaluate dynamics of subgenomic RNA (sgRNA) COVID-19 before after receiving remdesivir. Methods included consecutive admitted for who received remdesivir according our institutional protocol accepted participate study. A nasopharyngeal swab quantitative reverse transcriptase–polymerase chain reaction (qRT-PCR)...
Access and appropriateness of therapeutics for COVID-19 vary because access or regulatory barriers, the severity disease, some therapies, stage pandemic circulating variants. Remdesivir has shown benefits in clinical recovery is treatment choice selected patients, both hospitalized nonhospitalized, main international guidelines. The use remdesivir alternatives to conventional hospitalization such as hospital at home (HaH) units remains incompletely explored. In this study, we aim describe...
The study aims to describe characteristics and clinical outcome of patients with SARS-CoV-2 infection that received siltuximab according a protocol aimed early block the activity IL-6 avoid progression inflammatory flare.Retrospective review first 31 treated siltuximab, in Hospital Clinic Barcelona or Universitario Salamanca, from March April 2020 positive polymerase-chain reaction (PCR) nasopharyngeal swab.The cohort included cases median (IQR) age 62 (56-71) 71% were males. most frequent...
The study aim was to assess the influence of inflammatory response modifiers, including anti-interleukin-6 (IL-6) biologics and corticosteroids, on incidence hospital-acquired infections in patients with coronavirus disease 2019 (COVID-19). Case–control performed at a university hospital from February 26 May 26, 2020. Cases were defined as COVID-19 who developed infections. For each case, two controls selected among without matched obeying three criteria hierarchical sequence: length stay up...