A5109311214- Parasites and Host Interactions
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Malaria Research and Control
- Infectious Diseases and Tuberculosis
- Zoonotic diseases and public health
- Immunodeficiency and Autoimmune Disorders
- Parasite Biology and Host Interactions
- Leptospirosis research and findings
- Pneumonia and Respiratory Infections
- Parasitic infections in humans and animals
- Fungal Infections and Studies
- Mosquito-borne diseases and control
- Cutaneous lymphoproliferative disorders research
- Pneumocystis jirovecii pneumonia detection and treatment
- Amoebic Infections and Treatments
- Drug-Induced Hepatotoxicity and Protection
- SARS-CoV-2 and COVID-19 Research
- Infectious Diseases and Mycology
- Global Maternal and Child Health
- Nail Diseases and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Adenosine and Purinergic Signaling
Meyer Children's Hospital
2016-2025
University of Florence
2009-2020
Temple Street Children's University Hospital
2016
Institut Louis Malardé
2015
Ospedale Sacro Cuore Don Calabria
2015
Ospedale Santa Maria della Misericordia di Udine
2015
Université de Perpignan
2015
Radboud University Nijmegen
2015
Université de Toulouse
2015
Assistance Publique – Hôpitaux de Paris
2015
Interferon-gamma release assays (IGRAs) have been recently developed for the diagnosis of tuberculosis (TB) infection. The aim present study was to evaluate performance an enzyme-linked immunosorbent assay (ELISA)-based IGRA detecting TB in children.A prospective 336 children at risk infection carried out. All were tested with tuberculin skin test (TST) and a commercial ELISA-based [QuantiFERON-TB Gold In-Tube (Cellestis)].TST positive 58 (17.3%) 60 (17.9%) children. Two (0.6%) results...
Knowing the incidence of invasive meningococcal disease (IMD) is essential for planning appropriate vaccination policies. However, IMD may be underestimated because misdiagnosis or insufficiently sensitive laboratory methods. Using a national molecular surveillance register, we assessed number cases misdiagnosed and diagnoses obtained postmortem with real-time PCR (rPCR), compared sensitivity rPCR versus culture-based testing. A total 222 were identified: 11 (42%) 26 fatal had been...
Urinary tract infection (UTI) is a frequent disorder of childhood, caused mainly by Gram negative Enterobacterales. The aim this study to evaluate etiology and antimicrobial susceptibility patterns bacterial isolates in urine cultures children under the age 6 analyze relationship between previous hospitalization or antibiotic prescriptions resistance rates.A retrospective on positive from 13 public laboratories Tuscany, Italy was conducted. Data were obtained reviewing records...
Atopic dermatitis (AD) is a common disease affecting nearly 20% of the pediatric population in developed countries. The use biologic therapies, such as dupilumab, has considerably changed treatment AD. However, effects drugs on immune system may raise doubts and concerns, particularly special populations, like those with active or latent infections [1]. Here, we present case patient AD who was found to be infected Mycobacterium tuberculosis during dupilumab. Our 12-year-old boy suffered from...
Infectious diseases are common in internationally adopted children (IAC).With the objective to evaluate infectious prevalence a large cohort of IAC and explore possible risk factors for tuberculosis (TB) parasitic infections, clinical laboratory data at first screening visit all (<18 years) consecutively referred our Center 2009 2015 were collected analyzed.In total, 1612 (median age: 5.40 years; interquartile range: 3.00-7.90) enrolled, 123/1612 (7.60%) having medical conditions included...
The aim of the present study is to describe clinical features and outcomes childhood lymphadenopathy define factors able predict neoplastic aetiology or may improve its prognosis.All children evaluated for in our tertiary children's hospital who underwent their first examination between 1 January, 2015 31 December, 2017 were enrolled this retrospective observational study. Data analysed using SPSS.Statistics, 24.0.A total 322 children, aged 0 18 years (median 4.5; interquartile range 2.5-9),...
This study is the largest report on Mycobacterium tuberculosis transmission rate (TR) from children with pulmonary to school pupils. Higher TR (around 21.6%) was observed in contacts of smear-positive children. pediatric smear-negative index cases around 0. If our data are confirmed, a case could be screened only by clinical evaluation and tuberculin skin test, avoiding routine use chest radiographs less than 5 years age as well.
Background: Isoniazid monotherapy for six or nine months and the combination of isoniazid rifampicin three four are most used regimens treating latent tuberculosis. The main aim this retrospective study is to evaluate safety tuberculosis treatment by analysing side effects in both regimens.Research design methods: Children with treated were included. Periodic evaluations clinical assessment blood exams carried out detect any adverse reaction, including elevated serum transaminases.Results:...
The addition of intravenous quinine (IVQ) to artesunate (IVA) has been recently suggested by World Health Organization in areas where artemisinin resistance is highly prevalent. Since IVA not yet widely available as "Good Manufacturing Practices" product, for several years combination treatment with and IVQ was used some Italian centers mitigate the legal risks using an unlicensed drug.A retrospective cohort study designed compare + imported severe malaria. We collected data from three...
We describe the case of a 2-month-old baby with congenital syphilis, presenting limb paralysis. The radiological investigations showed periosteal thickenings limb. Despite negative maternal serology during first trimester pregnancy, clinical and features led to suspicion pseudoparalysis Parrot, which was confirmed by blood tests. Delayed diagnoses or misdiagnoses are possible when uncommon presentations forgotten diseases occur. needing for second screening syphilis in high-risk pregnant...
Background: Few studies have evaluated long-COVID in adolescents. Methods: Cohort study. Demographics, clinical data, and the presence of 30 symptoms were collected with a modified WHO form. Mean values compared by Student’s t test proportions chi-square or Fisher test, trends over time analysed using for trend. Potential risk factors independently associated persisting multivariable logistic regression model. Clustering cases was two-step automatic clustering. Results: A total 97...
Immune response to tuberculosis (TB) has been extensively studied in the past decades and classically involves cellular immunity. However, evidence suggests that humoral immunity may play a relevant role. Past studies regarding serum immunoglobulin (Ig) levels TB are dated only involve adult subjects. In this study, we retrospectively cohort of 256 children with disease analyzed 111 patients screened for total Ig at diagnosis. According severity extent organ involvement, subjects were...